Development Level

Tbio 55 | 11,445
Tchem 35 | 1,598
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
abnormal embryo turning 3 | 31
abnormal heart morphology 3 | 162
abnormal blood vessel morpholo... 2 | 5
decreased circulating glucose ... 2 | 126
decreased fasted circulating g... 2 | 65
decreased mean platelet volume 2 | 25
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
enlarged spleen 2 | 41
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased erythrocyte cell num... 1 | 62
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
enlarged thymus 1 | 5
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating potassiu... 1 | 29
increased glycosylated hemoglo... 1 | 1
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
pale yolk sac 1 | 25
pallor 1 | 34
sclerocornea 1 | 2

Disease

Carcinoma 58 | 11,493
osteosarcoma 57 | 7,950
ovarian cancer 55 | 8,520
lung cancer 46 | 4,740
glioblastoma 44 | 5,792
medulloblastoma, large-cell 44 | 6,241
Cancer 37 | 2,499
group 3 medulloblastoma 36 | 4,104
atypical teratoid / rhabdoid tumor 35 | 5,112
psoriasis 35 | 6,694
malignant mesothelioma 33 | 3,232
primitive neuroectodermal tumor 32 | 3,035
Breast cancer 30 | 3,578
adult high grade glioma 28 | 3,801
ependymoma 28 | 4,679
non-small cell lung cancer 26 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
oligodendroglioma 21 | 2,850
astrocytic glioma 19 | 2,597
colon cancer 19 | 1,478
invasive ductal carcinoma 19 | 2,951
ductal carcinoma in situ 16 | 1,745
nasopharyngeal carcinoma 16 | 1,058
Astrocytoma, Pilocytic 15 | 3,081
adrenocortical carcinoma 15 | 1,428
Kidney cancer 14 | 2,613
Autosomal recessive predisposition 13 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
subependymal giant cell astrocytoma 13 | 2,287
Intellectual disability 12 | 1,016
Breast Neoplasms 11 | 445
Mammary Neoplasms 11 | 425
breast carcinoma 11 | 1,638
diabetes mellitus 11 | 1,728
lung adenocarcinoma 11 | 2,716
Ataxia telangiectasia 10 | 34
Pick disease 10 | 1,894
group 4 medulloblastoma 10 | 1,855
pituitary cancer 10 | 1,972
Nijmegen breakage syndrome 9 | 24
Small head 9 | 374
lung carcinoma 9 | 2,843
Bloom syndrome 8 | 29
Hereditary Breast and Ovarian Cancer Syndrome 8 | 14
Schizophrenia 8 | 1,160
Short stature 8 | 531
juvenile dermatomyositis 8 | 1,187
pancreatic cancer 8 | 2,398
pediatric high grade glioma 8 | 1,064
Alzheimer's disease 7 | 658
Dull intelligence 7 | 645
Endometriosis 7 | 540
Hypoplastic mandible condyle 7 | 275
Low intelligence 7 | 645
Mandibular hypoplasia 7 | 275
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Micrognathism 7 | 275
Poor school performance 7 | 645
Prostatic Neoplasms 7 | 495
Waldenstrons macroglobulinemia 7 | 765
acute quadriplegic myopathy 7 | 1,158
interstitial cystitis 7 | 2,312
tuberculosis 7 | 2,010
Amyotrophic lateral sclerosis 6 | 451
Atopic dermatitis 6 | 952
Fanconi anemia 6 | 56
Rheumatoid arthritis 6 | 1,191
Seckel syndrome 6 | 34
Skin Neoplasms 6 | 69
Squamous cell carcinoma 6 | 129
Stomach Neoplasms 6 | 300
cutaneous lupus erythematosus 6 | 1,057
cystic fibrosis 6 | 1,696
non primary Sjogren syndrome sicca 6 | 891
ulcerative colitis 6 | 1,819
Anemia 5 | 365
Asthma 5 | 385
Carcinoma, Squamous Cell 5 | 110
Convex nasal ridge 5 | 37
Epidermodysplasia verruciformis 5 | 21
Lymphoma 5 | 81
Melanoma 5 | 711
Microcephaly 5 | 166
Multiple myeloma 5 | 1,332
Narrow face 5 | 54
Pancreatic Neoplasm 5 | 85
Prostate cancer 5 | 175
Renal Cell Carcinoma 5 | 214
Thin face 5 | 54
Xeroderma pigmentosum 5 | 43
astrocytoma 5 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
medulloblastoma 5 | 720
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
posterior fossa group A ependymoma 5 | 468
tuberculosis and treatment for 6 months 5 | 409
Chronic Lymphocytic Leukemia 4 | 262
acute myeloid leukemia 4 | 783
dermatomyositis 4 | 966

Tissue

Endocrine System 91 | 18,159
Digestive Tract 90 | 17,369
Female tissues 90 | 17,400
Male tissues 90 | 17,142
Skin and soft tissues 90 | 17,230
Blood and immune system 89 | 16,909
Cardiovascular System 89 | 15,192
Liver and Pancreas 89 | 16,750
Nervous System 89 | 16,725
Respiratory system 89 | 16,393
Urinary Tract 89 | 16,678

Target Family

Non-IDG 48 | 12,091
Kinase 25 | 634
Enzyme 13 | 4,145
Epigenetic 3 | 242
Transcription Factor 2 | 1,400

Reactome Pathway

Regulation of TP53 Activity th... 91 | 91
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Transcription initiation factor TFIID subunit 9B TAF9B Tbio Non-IDG -1.38372 23.5 105
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RHNO1 Tbio Non-IDG -3.20363 1560.8 3
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
Targeting protein for Xklp2 TPX2 Tbio Non-IDG -2.21148 180.0 435
FACT complex subunit SPT16 SUPT16H Tbio Enzyme -1.85453 70.7 324