Development Level

Tchem 11 | 1,598
Tbio 6 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
abnormal iris morphology 1 | 13
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating serum al... 1 | 82
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
irregularly shaped pupil 1 | 7
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 13 | 11,493
osteosarcoma 12 | 7,950
ovarian cancer 12 | 8,520
lung cancer 11 | 4,740
Cancer 9 | 2,499
glioblastoma 8 | 5,792
medulloblastoma, large-cell 7 | 6,241
group 3 medulloblastoma 6 | 4,104
oligodendroglioma 6 | 2,850
primitive neuroectodermal tumor 6 | 3,035
psoriasis 6 | 6,694
Breast Neoplasms 5 | 445
Breast cancer 5 | 3,578
Mammary Neoplasms 5 | 425
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
adult high grade glioma 4 | 3,801
juvenile dermatomyositis 4 | 1,187
malignant mesothelioma 4 | 3,232
Anemia 3 | 365
Astrocytoma, Pilocytic 3 | 3,081
Colonic Neoplasms 3 | 142
Colorectal Neoplasms 3 | 243
Encephalopathy, progressive 3 | 6
Epilepsy 3 | 792
Increased risk of pancreatic cancer 3 | 9
Li-Fraumeni syndrome 3 | 13
Lung Neoplasms 3 | 232
Lymphoma 3 | 81
Malignant neoplasm of pancreas 3 | 9
Malignant neoplasm of skin 3 | 15
Melanoma 3 | 711
Nervous System Neoplasms 3 | 8
Pancreatic Neoplasm 3 | 85
Progressive brain disease 3 | 6
Prostate cancer 3 | 175
Prostatic Neoplasms 3 | 495
Renal Cell Carcinoma 3 | 214
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Skin Neoplasms 3 | 69
Stomach Neoplasms 3 | 300
Tumors of Adrenal Cortex 3 | 3
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
hepatocellular carcinoma 3 | 547
pancreatic cancer 3 | 2,398
Abnormality of metabolism/homeostasis 2 | 134
Adenocarcinoma of lung (disorder) 2 | 60
Adenoid Cystic Carcinoma 2 | 99
Alcoholic Intoxication, Chronic 2 | 289
Amyotrophic lateral sclerosis 2 | 451
Autistic Disorder 2 | 364
Bladder Neoplasm 2 | 112
Carcinoma, Adenoid Cystic 2 | 99
Carcinoma, Non-Small-Cell Lung 2 | 107
Carcinoma, Squamous Cell 2 | 110
Carcinoma, Transitional Cell 2 | 32
Cell Transformation, Neoplastic 2 | 97
DOID:2627 2 | 94
Endometrial cancer 2 | 311
Esophageal Neoplasms 2 | 69
Esophageal Squamous Cell Carcinoma 2 | 77
Gastrointestinal stromal tumor 2 | 62
Glaucoma 2 | 239
Glioma 2 | 74
Infertility, Male 2 | 46
Kleefstra syndrome 2 | 12
Large intestine cancer 2 | 126
Leiomyosarcoma of uterus 2 | 13
Lymphoid leukemia 2 | 160
Major Depressive Disorder 2 | 301
Male infertility 2 | 206
Malignant neoplasm of prostate 2 | 11
Neoplasm Metastasis 2 | 168
Neoplastic Cell Transformation 2 | 89
Neurodegenerative disease 2 | 414
Nijmegen breakage syndrome 2 | 24
Pick disease 2 | 1,894
Pick's disease 2 | 15
Retinoblastoma 2 | 19
Sarcoma 2 | 62
Schizophrenia 2 | 1,160
Small cell carcinoma of lung 2 | 45
Squamous cell carcinoma 2 | 129
Squamous cell carcinoma of esophagus 2 | 77
Stomach cancer 2 | 30
T-Cell Lymphoma 2 | 13
Transitional cell carcinoma of bladder 2 | 17
Urinary Bladder Neoplasms 2 | 114
active Crohn's disease 2 | 922
non-small cell lung cancer 2 | 2,890
non-small cell lung carcinoma 2 | 317
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Non-IDG 8 | 12,091
Epigenetic 6 | 242
Enzyme 1 | 4,145
Kinase 1 | 634
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

Reactome Pathway

Regulation of TP53 Activity th... 18 | 18
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Junction-mediating and -regulatory protein JMY Tbio Non-IDG -1.26760 21.2 162
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Serine/threonine-protein kinase Chk2 CHEK2 Tchem Kinase -3.00304 978.7 1374
Protein arginine N-methyltransferase 5 PRMT5 Tchem Epigenetic -2.18391 171.0 447
N-lysine methyltransferase KMT5A KMT5A Tchem Epigenetic -1.89071 71.7 420
Histone-lysine N-methyltransferase EHMT2 EHMT2 Tchem Epigenetic -2.49970 327.4 277
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298