Development Level

Tbio 10 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

abnormal bone mineralization 1 | 38
abnormal glucose homeostasis 1 | 4
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499
thrombocytosis 1 | 27

Disease

Carcinoma 13 | 11,493
osteosarcoma 9 | 7,950
Cancer 8 | 2,499
medulloblastoma, large-cell 7 | 6,241
ovarian cancer 6 | 8,520
adult high grade glioma 5 | 3,801
atypical teratoid / rhabdoid tumor 5 | 5,112
lung cancer 5 | 4,740
psoriasis 5 | 6,694
Breast Neoplasms 4 | 445
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
group 3 medulloblastoma 4 | 4,104
malignant mesothelioma 4 | 3,232
Amyotrophic lateral sclerosis 3 | 451
Breast cancer 3 | 3,578
Epilepsy 3 | 792
Kidney cancer 3 | 2,613
Lung Neoplasms 3 | 232
Seizures 3 | 596
nasopharyngeal carcinoma 3 | 1,058
Adenocarcinoma 2 | 122
Adenocarcinoma of lung (disorder) 2 | 60
Astrocytoma, Pilocytic 2 | 3,081
Autosomal recessive predisposition 2 | 1,442
Carcinoma, Squamous Cell 2 | 110
Cell Transformation, Neoplastic 2 | 97
Colorectal Neoplasms 2 | 243
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Ganglioglioma 2 | 13
Glaucoma 2 | 239
High forehead 2 | 102
Hydrocephalus 2 | 152
Lymphoid leukemia 2 | 160
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Microstomia 2 | 78
Neoplasm Metastasis 2 | 168
Neoplastic Cell Transformation 2 | 89
Ocular hypertension 2 | 42
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85
Polycystic ovary syndrome 2 | 360
Rheumatoid arthritis 2 | 1,191
Skin cancer 2 | 469
Small cell carcinoma of lung 2 | 45
Squamous cell carcinoma 2 | 129
Tall forehead 2 | 102
Ventricular Septal Defects 2 | 119
acute myeloid leukemia 2 | 783
adrenocortical carcinoma 2 | 1,428
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
esophageal adenocarcinoma 2 | 737
group 4 medulloblastoma 2 | 1,855
interstitial cystitis 2 | 2,312
invasive ductal carcinoma 2 | 2,951
lung small cell carcinoma 2 | 4
medulloblastoma 2 | 720
non primary Sjogren syndrome sicca 2 | 891
non-small cell lung carcinoma 2 | 317
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
primitive neuroectodermal tumor 2 | 3,035
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
16q24.3 microdeletion syndrome 1 | 6
Absence of a tooth 1 | 6
Absent scalp hair 1 | 5
Ankyloblepharon 1 | 4
Ankyloblepharon filiforme adnatum 1 | 4
Blepharitis 1 | 23
Cellulitis of eyelid 1 | 17
Congenital neurologic anomalies 1 | 20
Dystrophic toenail changes 1 | 12
Eczema 1 | 45
Familial partial lipodystrophy 1 | 12
Hemimegalencephaly 1 | 5
Hemiplegia 1 | 25
Insulin resistant diabetes 1 | 13
Lacrimation abnormality 1 | 4
Lipomatosis 1 | 12
Loss of scalp hair 1 | 5
Malformations of Cortical Development 1 | 13
Nonsyndromic congenital nail disorder 1 1 | 3
Oval face 1 | 5
Retinal ischemia 1 | 7
Rhabdomyosarcoma, Alveolar 1 | 4
Selective tooth agenesis 1 | 6
Small labia majora 1 | 16
Split hand-foot malformation 1 | 18
Tuberous sclerosis 1 | 19
Ureterocele 1 | 14
blue iris (physical finding) 1 | 17

Tissue

Endocrine System 13 | 18,159
Blood and immune system 12 | 16,909
Digestive Tract 12 | 17,369
Female tissues 12 | 17,400
Nervous System 12 | 16,725
Skin and soft tissues 12 | 17,230
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Respiratory system 11 | 16,393
Urinary Tract 11 | 16,678
Cardiovascular System 10 | 15,192

Target Family

Non-IDG 5 | 12,091
Transcription Factor 5 | 1,400
Kinase 2 | 634
Epigenetic 1 | 242

Reactome Pathway

Regulation of TP53 Activity th... 13 | 13
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apoptosis-stimulating of p53 protein 2 TP53BP2 Tbio Non-IDG -1.85307 72.5 189
Zinc finger protein 385A ZNF385A Tbio Non-IDG -0.03141 1.24 99
Protein BANP BANP Tbio Non-IDG -1.67812 53.3 92
POU domain, class 4, transcription factor 2 POU4F2 Tbio Transcription Factor -1.94397 90.2 145
RelA-associated inhibitor PPP1R13L Tbio Non-IDG -1.76131 64.5 185
POU domain, class 4, transcription factor 1 POU4F1 Tbio Transcription Factor -2.19846 154.8 107
Tumor protein p73 TP73 Tbio Transcription Factor -1.92832 82.6 708
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
PHD finger protein 20 PHF20 Tbio Epigenetic -2.89181 748.7 104
Tumor protein 63 TP63 Tbio Transcription Factor -3.07398 1154.1 448