Development Level

Tbio 95 | 10,625
Tchem 59 | 1,890
Tclin 3 | 602
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 6 | 134

IMPC Term

preweaning lethality, complete... 10 | 633
embryonic lethality prior to o... 5 | 148
abnormal lens morphology 4 | 73
decreased circulating LDL chol... 4 | 37
embryonic lethality prior to t... 4 | 187
decreased lean body mass 3 | 195
increased circulating LDL chol... 3 | 15
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal maxilla morphology 2 | 16
abnormal tooth morphology 2 | 24
cataract 2 | 26
decreased T cell number 2 | 31
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased fasted circulating g... 2 | 49
decreased mean corpuscular vol... 2 | 50
decreased total body fat amoun... 2 | 186
enlarged spleen 2 | 26
hypoactivity 2 | 89
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased mean platelet volume 2 | 19
increased neutrophil cell numb... 2 | 15
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coat/ hair morphology 1 | 18
abnormal embryo size 1 | 112
abnormal glucose homeostasis 1 | 5
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased CD5-positive Ly6C-po... 1 | 4
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating amylase ... 1 | 24
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
enlarged heart 1 | 111
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 52
increased cardiac stroke volum... 1 | 1
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased effector memory T-he... 1 | 5
increased glycosylated hemoglo... 1 | 1
increased grip strength 1 | 83
increased heart rate 1 | 17
increased heart weight 1 | 37
increased kidney weight 1 | 4
increased lean body mass 1 | 107
increased memory-marker gamma-... 1 | 2
increased monocyte cell number 1 | 27
increased red blood cell distr... 1 | 21
increased spleen weight 1 | 3
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
shortened RR interval 1 | 19
thrombocytosis 1 | 23
tremors 1 | 34

Disease

ovarian cancer 98 | 8,484
osteosarcoma 97 | 7,933
medulloblastoma, large-cell 71 | 6,234
glioblastoma 68 | 5,572
Cancer 67 | 2,346
lung cancer 64 | 4,466
psoriasis 59 | 6,685
malignant mesothelioma 46 | 3,162
primitive neuroectodermal tumor 44 | 3,031
atypical teratoid / rhabdoid tumor 42 | 4,369
Breast cancer 41 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,289
group 3 medulloblastoma 32 | 2,254
oligodendroglioma 32 | 2,849
non-small cell lung cancer 31 | 2,798
adult high grade glioma 30 | 2,148
ependymoma 28 | 2,514
pediatric high grade glioma 28 | 2,712
Carcinoma 27 | 2,147
invasive ductal carcinoma 26 | 2,950
astrocytic glioma 25 | 2,241
colon cancer 25 | 1,475
subependymal giant cell astrocytoma 24 | 2,287
adrenocortical carcinoma 23 | 1,427
pilocytic astrocytoma 23 | 3,086
diabetes mellitus 21 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
ductal carcinoma in situ 20 | 1,745
nasopharyngeal carcinoma 20 | 1,056
medulloblastoma 19 | 1,524
sonic hedgehog group medulloblastoma 19 | 1,482
group 4 medulloblastoma 18 | 1,875
lung adenocarcinoma 18 | 2,713
Intellectual disability 17 | 573
atypical teratoid/rhabdoid tumor 17 | 1,095
pituitary cancer 17 | 1,972
Mammary Neoplasms 16 | 410
Rheumatoid Arthritis 16 | 1,160
pancreatic cancer 16 | 2,300
Pick disease 15 | 1,893
posterior fossa group A ependymoma 15 | 1,511
ulcerative colitis 15 | 2,087
Waldenstrons macroglobulinemia 14 | 765
acute quadriplegic myopathy 14 | 1,157
astrocytoma 14 | 1,493
lung carcinoma 14 | 2,844
juvenile dermatomyositis 13 | 1,189
Endometriosis 12 | 535
interstitial cystitis 12 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
tuberculosis and treatment for 6 months 12 | 686
Melanoma 11 | 261
Multiple myeloma 11 | 1,327
Neoplastic Syndromes, Hereditary 11 | 48
Peripheral Neuropathy 11 | 303
acute myeloid leukemia 11 | 780
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
non primary Sjogren syndrome sicca 11 | 840
Amyotrophic Lateral Sclerosis 10 | 431
Lung Neoplasms 10 | 171
Nijmegen breakage syndrome 10 | 23
posterior fossa group B ependymoma 10 | 1,530
tuberculosis 10 | 1,557
Alzheimer's disease 9 | 644
Ataxia telangiectasia 9 | 31
Atopic dermatitis 9 | 944
Bloom syndrome 9 | 30
Schizophrenia 9 | 501
Squamous cell carcinoma 9 | 94
breast carcinoma 9 | 1,614
cutaneous lupus erythematosus 9 | 1,056
Asthma 8 | 349
Prostatic Neoplasms 8 | 471
Stomach Neoplasms 8 | 282
cystic fibrosis 8 | 1,665
gastric carcinoma 8 | 832
Chronic Lymphocytic Leukemia 7 | 242
Colorectal Neoplasms 7 | 217
Fanconi's anemia 7 | 50
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
IGA Glomerulonephritis 7 | 454
Pancreatic Neoplasm 7 | 79
Seckel syndrome 7 | 34
active Crohn's disease 7 | 918
dermatomyositis 7 | 933
primary pancreatic ductal adenocarcinoma 7 | 1,271
Adenoid Cystic Carcinoma 6 | 99
Epidermodysplasia verruciformis 6 | 21
Liver carcinoma 6 | 217
Malignant neoplasm of breast 6 | 63
Microcephaly 6 | 149
Obesity 6 | 616
Parkinson's disease 6 | 364
Prostate cancer 6 | 172
Renal Cell Carcinoma 6 | 199
Vascular disease 6 | 281
esophageal adenocarcinoma 6 | 737
pancreatic carcinoma 6 | 567
progressive supranuclear palsy 6 | 674
spina bifida 6 | 1,064

Tissue

Endocrine System 159 | 18,512
Blood and immune system 158 | 17,995
Cardiovascular System 158 | 17,958
Digestive Tract 158 | 18,473
Female tissues 158 | 18,647
Liver and Pancreas 158 | 18,136
Male tissues 158 | 17,969
Nervous System 158 | 18,561
Respiratory system 157 | 17,484
Urinary Tract 157 | 18,444
Skin and soft tissues 155 | 18,115

Target Family

Non-IDG 66 | 11,971
Kinase 37 | 634
Enzyme 24 | 4,146
Epigenetic 21 | 242
Transcription Factor 9 | 1,400
TF/Epigenetic 2 | 38

Reactome Pathway

Regulation of TP53 Activity 159 | 159
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Homeodomain-interacting protein kinase 1 HIPK1 Tbio Kinase -0.62325 4.93 166
SET domain-containing protein 9 SETD9 Tdark Non-IDG 0.21 0.40 71
Transcriptional repressor p66-alpha GATAD2A Tbio Non-IDG -0.79314 7.11 142
PHD finger protein 20 PHF20 Tbio Epigenetic -2.79926 660.7 91
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.17350 165.7 375
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150