Development Level

Tbio 97 | 11,445
Tchem 57 | 1,598
Tclin 3 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 9 | 499
embryonic lethality prior to o... 8 | 239
embryonic lethality prior to t... 8 | 278
abnormal embryo size 4 | 220
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased circulating LDL chol... 4 | 38
abnormal embryo turning 3 | 31
abnormal heart morphology 3 | 162
abnormal retinal blood vessel ... 3 | 26
abnormal retinal vasculature m... 3 | 27
decreased body weight 3 | 161
decreased circulating glucose ... 3 | 126
increased circulating HDL chol... 3 | 80
increased circulating LDL chol... 3 | 13
increased lean body mass 3 | 172
increased mean platelet volume 3 | 45
abnormal behavior 2 | 298
abnormal blood vessel morpholo... 2 | 5
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
decreased blood urea nitrogen ... 2 | 51
decreased circulating choleste... 2 | 93
decreased fasted circulating g... 2 | 65
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
enlarged spleen 2 | 41
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
abnormal chorioallantoic fusio... 1 | 8
abnormal coat- hair morphology 1 | 19
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal iris morphology 1 | 13
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal pharyngeal arch morph... 1 | 8
abnormal response to new envir... 1 | 10
abnormal somite shape 1 | 5
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
enlarged thymus 1 | 5
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased body temperature 1 | 9
increased circulating bilirubi... 1 | 16
increased circulating potassiu... 1 | 29
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 115 | 11,493
osteosarcoma 99 | 7,950
ovarian cancer 99 | 8,520
medulloblastoma, large-cell 72 | 6,241
glioblastoma 71 | 5,792
Cancer 69 | 2,499
lung cancer 68 | 4,740
psoriasis 59 | 6,694
atypical teratoid / rhabdoid tumor 58 | 5,112
group 3 medulloblastoma 53 | 4,104
Breast cancer 48 | 3,578
adult high grade glioma 47 | 3,801
malignant mesothelioma 46 | 3,232
primitive neuroectodermal tumor 44 | 3,035
ependymoma 43 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
oligodendroglioma 32 | 2,850
non-small cell lung cancer 31 | 2,890
Kidney cancer 29 | 2,613
astrocytic glioma 29 | 2,597
colon cancer 26 | 1,478
invasive ductal carcinoma 26 | 2,951
Astrocytoma, Pilocytic 24 | 3,081
subependymal giant cell astrocytoma 24 | 2,287
adrenocortical carcinoma 23 | 1,428
Intellectual disability 22 | 1,016
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
diabetes mellitus 20 | 1,728
ductal carcinoma in situ 20 | 1,745
group 4 medulloblastoma 20 | 1,855
nasopharyngeal carcinoma 20 | 1,058
Breast Neoplasms 18 | 445
Schizophrenia 18 | 1,160
lung adenocarcinoma 18 | 2,716
pancreatic cancer 17 | 2,398
pituitary cancer 17 | 1,972
Autosomal recessive predisposition 16 | 1,442
Mammary Neoplasms 16 | 425
Rheumatoid arthritis 16 | 1,191
Pick disease 15 | 1,894
Waldenstrons macroglobulinemia 14 | 765
acute quadriplegic myopathy 14 | 1,158
breast carcinoma 14 | 1,638
lung carcinoma 14 | 2,843
tuberculosis 14 | 2,010
ulcerative colitis 14 | 1,819
Endometriosis 13 | 540
Melanoma 13 | 711
juvenile dermatomyositis 13 | 1,187
medulloblastoma 13 | 720
Multiple myeloma 12 | 1,332
Squamous cell carcinoma 12 | 129
interstitial cystitis 12 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
pediatric high grade glioma 12 | 1,064
Ataxia telangiectasia 11 | 34
Carcinoma, Squamous Cell 11 | 110
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Short stature 11 | 531
Small head 11 | 374
acute myeloid leukemia 11 | 783
astrocytoma 11 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
non primary Sjogren syndrome sicca 11 | 891
Amyotrophic lateral sclerosis 10 | 451
Epilepsy 10 | 792
Lung Neoplasms 10 | 232
Nijmegen breakage syndrome 10 | 24
Stomach Neoplasms 10 | 300
tuberculosis and treatment for 6 months 10 | 409
Alzheimer's disease 9 | 658
Atopic dermatitis 9 | 952
Bloom syndrome 9 | 29
Endometrial cancer 9 | 311
Glaucoma 9 | 239
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Pancreatic Neoplasm 9 | 85
Prostatic Neoplasms 9 | 495
Seizures 9 | 596
cutaneous lupus erythematosus 9 | 1,057
Chronic Lymphocytic Leukemia 8 | 262
Hereditary Breast and Ovarian Cancer Syndrome 8 | 14
Liver cancer 8 | 604
cystic fibrosis 8 | 1,696
dermatomyositis 8 | 966
gastric carcinoma 8 | 807
Asthma 7 | 385
Bipolar Disorder 7 | 666
Immune system cancer 7 | 140
Lymphoma 7 | 81
Microcephaly 7 | 166
Pancreatic Neoplasms 7 | 85
active Crohn's disease 7 | 922
primary pancreatic ductal adenocarcinoma 7 | 1,109

Tissue

Endocrine System 158 | 18,159
Digestive Tract 156 | 17,369
Female tissues 156 | 17,400
Skin and soft tissues 156 | 17,230
Blood and immune system 155 | 16,909
Male tissues 155 | 17,142
Nervous System 155 | 16,725
Liver and Pancreas 154 | 16,750
Respiratory system 154 | 16,393
Urinary Tract 154 | 16,678
Cardiovascular System 152 | 15,192

Target Family

Non-IDG 68 | 12,091
Kinase 36 | 634
Enzyme 23 | 4,145
Epigenetic 21 | 242
Transcription Factor 9 | 1,400
TF/Epigenetic 2 | 38

Reactome Pathway

Regulation of TP53 Activity 159 | 159
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methyl-CpG-binding domain protein 3 MBD3 Tbio Transcription Factor -0.85800 7.92 309
Bromodomain and PHD finger-containing protein 3 BRPF3 Tchem Epigenetic -0.46982 2.70 64
Apoptosis-stimulating of p53 protein 2 TP53BP2 Tbio Non-IDG -1.85307 72.5 189
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Chromodomain-helicase-DNA-binding protein 4 CHD4 Tbio Epigenetic -2.22229 159.7 203
Zinc finger protein 385A ZNF385A Tbio Non-IDG -0.03141 1.24 99
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Transcription initiation factor TFIID subunit 9B TAF9B Tbio Non-IDG -1.38372 23.5 105
Protein BANP BANP Tbio Non-IDG -1.67812 53.3 92
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376