Development Level

Tbio 44 | 11,445
Tclin 6 | 613
Tchem 5 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
abnormal lens morphology 2 | 81
cataract 2 | 92
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal eyelid morphology 1 | 7
abnormal femur morphology 1 | 14
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal locomotor behavior 1 | 24
abnormal placement of pupils 1 | 6
corneal opacity 1 | 32
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased hemoglobin content 1 | 68
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
increased heart weight 1 | 62
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

ovarian cancer 42 | 8,520
lung cancer 29 | 4,740
Multiple myeloma 28 | 1,332
Carcinoma 24 | 11,493
psoriasis 22 | 6,694
osteosarcoma 21 | 7,950
glioblastoma 18 | 5,792
Cancer 15 | 2,499
HIV Infections 15 | 102
Breast cancer 12 | 3,578
Waldenstrons macroglobulinemia 10 | 765
dermatomyositis 10 | 966
malignant mesothelioma 10 | 3,232
atypical teratoid / rhabdoid tumor 9 | 5,112
diabetes mellitus 9 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
pancreatic cancer 9 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
adult high grade glioma 8 | 3,801
non-small cell lung cancer 8 | 2,890
astrocytoma 7 | 1,146
ependymoma 7 | 4,679
subependymal giant cell astrocytoma 7 | 2,287
Astrocytoma, Pilocytic 6 | 3,081
Osteoporosis 6 | 363
lung carcinoma 6 | 2,843
medulloblastoma, large-cell 6 | 6,241
tuberculosis 6 | 2,010
Liver Cirrhosis, Experimental 5 | 769
Mantle cell lymphoma 5 | 23
acute myeloid leukemia 5 | 783
astrocytic glioma 5 | 2,597
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non primary Sjogren syndrome sicca 5 | 891
Bladder Neoplasm 4 | 112
Breast Neoplasms 4 | 445
Carcinoma, Squamous Cell 4 | 110
Esophageal Squamous Cell Carcinoma 4 | 77
Mammary Neoplasms 4 | 425
Melanoma 4 | 711
Pick disease 4 | 1,894
Squamous cell carcinoma of esophagus 4 | 77
Stomach Neoplasms 4 | 300
Urinary Bladder Neoplasms 4 | 114
Vascular disease 4 | 319
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
invasive ductal carcinoma 4 | 2,951
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
oligodendroglioma 4 | 2,850
primary Sjogren syndrome 4 | 735
primitive neuroectodermal tumor 4 | 3,035
Adenocarcinoma 3 | 122
Anemia 3 | 365
Barrett's esophagus 3 | 182
Carcinoma, Hepatocellular 3 | 228
Colorectal Neoplasms 3 | 243
Crohn's disease 3 | 321
Glaucoma 3 | 239
Immune system cancer 3 | 140
Li-Fraumeni syndrome 3 | 13
Lung Neoplasms 3 | 232
Lymphoid leukemia 3 | 160
Lymphoma 3 | 81
Major Depressive Disorder 3 | 301
Neoplasm Invasiveness 3 | 161
Pancreatic Neoplasm 3 | 85
Papilloma 3 | 44
Squamous cell carcinoma 3 | 129
active Crohn's disease 3 | 922
colon cancer 3 | 1,478
cutaneous lupus erythematosus 3 | 1,057
gastric cancer 3 | 459
interstitial cystitis 3 | 2,312
primary pancreatic ductal adenocarcinoma 3 | 1,109
ulcerative colitis 3 | 1,819
Animal Mammary Neoplasms 2 | 136
Congenital deafness 2 | 185
Congestive heart failure 2 | 113
DOID:2627 2 | 94
Deafness 2 | 198
Exophthalmos 2 | 112
Hearing Loss, Partial 2 | 185
Kidney Diseases 2 | 114
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Muscle Weakness 2 | 170
Myocardial Infarction 2 | 151
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Pneumonia 2 | 174
Primary cutaneous T-cell lymphoma 2 | 29
Prominent eyes 2 | 96
Prominent globes 2 | 96
Protruding eyes 2 | 96
Skeletal muscle atrophy 2 | 139
hearing impairment 2 | 199
muscle degeneration 2 | 139

Tissue

Blood and immune system 54 | 16,909
Digestive Tract 54 | 17,369
Endocrine System 54 | 18,159
Female tissues 54 | 17,400
Liver and Pancreas 54 | 16,750
Male tissues 54 | 17,142
Nervous System 54 | 16,725
Respiratory system 54 | 16,393
Skin and soft tissues 54 | 17,230
Urinary Tract 54 | 16,678
Cardiovascular System 53 | 15,192

Target Family

Enzyme 41 | 4,145
Non-IDG 12 | 12,091
Epigenetic 1 | 242
Kinase 1 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Regulation of RUNX3 expression... 56 | 56
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Putative protein SEM1, isoform 2 SEM1 Tbio Non-IDG 0.30 0.49 109
26S proteasome regulatory subunit 10B PSMC6 Tbio Enzyme -2.65165 339.0 214
Proteasome subunit alpha type-7 PSMA7 Tbio Enzyme -2.71627 496.7 288
Proteasome subunit alpha type-6 PSMA6 Tbio Enzyme -2.80973 614.4 288