Development Level

Tbio 57 | 11,445
Tclin 8 | 613
Tchem 5 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
enlarged lymph nodes 1 | 37
female infertility 1 | 60
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
prolonged QRS complex duration 1 | 8
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
trunk curl 1 | 16

Disease

ovarian cancer 50 | 8,520
lung cancer 35 | 4,740
Carcinoma 34 | 11,493
osteosarcoma 33 | 7,950
Multiple myeloma 30 | 1,332
psoriasis 29 | 6,694
glioblastoma 25 | 5,792
Cancer 20 | 2,499
medulloblastoma, large-cell 18 | 6,241
atypical teratoid / rhabdoid tumor 17 | 5,112
Breast cancer 16 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
HIV Infections 15 | 102
non-small cell lung cancer 14 | 2,890
ependymoma 13 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
group 3 medulloblastoma 12 | 4,104
malignant mesothelioma 12 | 3,232
Waldenstrons macroglobulinemia 11 | 765
adult high grade glioma 11 | 3,801
dermatomyositis 11 | 966
tuberculosis 11 | 2,010
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
subependymal giant cell astrocytoma 10 | 2,287
ulcerative colitis 10 | 1,819
Astrocytoma, Pilocytic 9 | 3,081
astrocytoma 9 | 1,146
invasive ductal carcinoma 9 | 2,951
oligodendroglioma 9 | 2,850
pancreatic cancer 9 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
interstitial cystitis 8 | 2,312
Cleft Palate 7 | 271
Kidney cancer 7 | 2,613
Osteoporosis 7 | 363
Pick disease 7 | 1,894
acute myeloid leukemia 7 | 783
astrocytic glioma 7 | 2,597
group 4 medulloblastoma 7 | 1,855
primitive neuroectodermal tumor 7 | 3,035
Alzheimer's disease 6 | 658
Autosomal recessive predisposition 6 | 1,442
Rheumatoid arthritis 6 | 1,191
lung adenocarcinoma 6 | 2,716
lung carcinoma 6 | 2,843
pituitary cancer 6 | 1,972
Mantle cell lymphoma 5 | 23
Obesity 5 | 678
active Crohn's disease 5 | 922
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
juvenile dermatomyositis 5 | 1,187
non primary Sjogren syndrome sicca 5 | 891
primary Sjogren syndrome 5 | 735
progressive supranuclear palsy 5 | 676
Atopic dermatitis 4 | 952
Breast Neoplasms 4 | 445
Cleidocranial dysplasia 4 | 10
Craniofacial Abnormalities 4 | 151
Depressive disorder 4 | 409
Liver Cirrhosis, Experimental 4 | 769
Mammary Neoplasms 4 | 425
Mental Depression 4 | 333
Myocardial Infarction 4 | 151
Parkinson's disease 4 | 392
Schizophrenia 4 | 1,160
Stevens-Johnson syndrome 4 | 92
Uranostaphyloschisis 4 | 167
Vascular disease 4 | 319
active ulcerative colitis 4 | 764
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 807
pediatric high grade glioma 4 | 1,064
primary pancreatic ductal adenocarcinoma 4 | 1,109
sarcoidosis 4 | 370
Acquired metabolic disease 3 | 336
Anemia 3 | 365
Bipolar Disorder 3 | 666
Carcinoma, Hepatocellular 3 | 228
Craniosynostosis 3 | 74
Esophageal Squamous Cell Carcinoma 3 | 77
Heart failure 3 | 162
Liver carcinoma 3 | 240
Major Depressive Disorder 3 | 301
Mood Disorders 3 | 184
Neoplasm Metastasis 3 | 168
Orbital separation excessive 3 | 244
Osteoarthritis 3 | 184
Prostatic Neoplasms 3 | 495
Short stature 3 | 531
Squamous cell carcinoma of esophagus 3 | 77
Syndactyly 3 | 88
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
hearing impairment 3 | 199
posterior fossa group B ependymoma 3 | 416

Tissue

Endocrine System 72 | 18,159
Blood and immune system 71 | 16,909
Digestive Tract 71 | 17,369
Female tissues 71 | 17,400
Male tissues 71 | 17,142
Nervous System 71 | 16,725
Urinary Tract 71 | 16,678
Cardiovascular System 70 | 15,192
Liver and Pancreas 70 | 16,750
Respiratory system 70 | 16,393
Skin and soft tissues 70 | 17,230

Target Family

Enzyme 45 | 4,145
Non-IDG 15 | 12,091
Transcription Factor 9 | 1,400
Nuclear Receptor 3 | 48
Kinase 1 | 634

Reactome Pathway

Regulation of RUNX2 expression... 73 | 73
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Putative protein SEM1, isoform 2 SEM1 Tbio Non-IDG 0.30 0.49 109
Proteasome subunit alpha type-2 PSMA2 Tbio Enzyme -0.82346 5.78 245