Development Level

Tbio 52 | 11,445
Tdark 6 | 6,588
Tchem 5 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal forebrain morphology 1 | 10
abnormal hair growth 1 | 10
abnormal kidney morphology 1 | 65
abnormal midbrain morphology 1 | 10
absent pinna reflex 1 | 23
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased lactate dehydrogenas... 1 | 16
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
hemorrhage 1 | 23
increased circulating HDL chol... 1 | 80
increased circulating glucose ... 1 | 24
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97

Disease

ovarian cancer 48 | 8,520
Carcinoma 32 | 11,493
lung cancer 29 | 4,740
osteosarcoma 28 | 7,950
Multiple myeloma 27 | 1,332
glioblastoma 23 | 5,792
psoriasis 23 | 6,694
HIV Infections 15 | 102
medulloblastoma, large-cell 15 | 6,241
Breast cancer 14 | 3,578
Cancer 14 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
atypical teratoid / rhabdoid tumor 12 | 5,112
ependymoma 12 | 4,679
dermatomyositis 11 | 966
group 3 medulloblastoma 11 | 4,104
astrocytic glioma 10 | 2,597
astrocytoma 10 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Pick disease 9 | 1,894
Waldenstrons macroglobulinemia 9 | 765
malignant mesothelioma 9 | 3,232
oligodendroglioma 9 | 2,850
Kidney cancer 8 | 2,613
pancreatic cancer 8 | 2,398
subependymal giant cell astrocytoma 8 | 2,287
Noonan syndrome 7 | 34
adult high grade glioma 7 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
juvenile dermatomyositis 7 | 1,187
lung adenocarcinoma 7 | 2,716
Astrocytoma, Pilocytic 6 | 3,081
Intellectual disability 6 | 1,016
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
invasive ductal carcinoma 6 | 2,951
lung carcinoma 6 | 2,843
non-small cell lung cancer 6 | 2,890
tuberculosis 6 | 2,010
Blepharoptosis 5 | 231
Costello Syndrome 5 | 17
Cryptorchidism 5 | 296
Downward slant of palpebral fissure 5 | 158
Dull intelligence 5 | 645
Epilepsy 5 | 792
Full lower lip 5 | 64
Hypoplastic mandible condyle 5 | 275
Low intelligence 5 | 645
Mandibular hypoplasia 5 | 275
Mantle cell lymphoma 5 | 23
Melanoma 5 | 711
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Micrognathism 5 | 275
Muscle Weakness 5 | 170
Muscle hypotonia 5 | 571
Neck webbing 5 | 35
Orbital separation excessive 5 | 244
Poor school performance 5 | 645
Prominent lower lip 5 | 64
Short stature 5 | 531
acute myeloid leukemia 5 | 783
non primary Sjogren syndrome sicca 5 | 891
Acquired scoliosis 4 | 281
Anemia 4 | 365
Animal Mammary Neoplasms 4 | 136
Bleeding tendency 4 | 37
Byzanthine arch palate 4 | 194
Cardiac Arrhythmia 4 | 103
Cardiac conduction abnormalities 4 | 78
Cognitive delay 4 | 608
Conduction disorder of the heart 4 | 79
Curvature of spine 4 | 282
Delayed bone age 4 | 136
EKG abnormalities 4 | 78
Electrocardiogram abnormal 4 | 81
Electrocardiogram change 4 | 78
Electroencephalogram abnormal 4 | 101
Endometrial cancer 4 | 311
Exophthalmos 4 | 112
Generalized osteopenia 4 | 99
Hepatomegaly 4 | 285
Joint hyperflexibility 4 | 78
Liver Cirrhosis, Experimental 4 | 769
Low posterior hairline 4 | 52
Mammary Neoplasms, Animal 4 | 136
Mammary Neoplasms, Experimental 4 | 154
Melanocytic nevus 4 | 43
Mental and motor retardation 4 | 608
Osteopenia 4 | 99
Osteoporosis 4 | 363
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Strabismus 4 | 270
esophageal adenocarcinoma 4 | 737
interstitial cystitis 4 | 2,312
primary Sjogren syndrome 4 | 735
primary pancreatic ductal adenocarcinoma 4 | 1,109
progressive supranuclear palsy 4 | 676
ulcerative colitis 4 | 1,819

Tissue

Endocrine System 67 | 18,159
Blood and immune system 66 | 16,909
Digestive Tract 66 | 17,369
Female tissues 66 | 17,400
Male tissues 66 | 17,142
Nervous System 66 | 16,725
Respiratory system 66 | 16,393
Urinary Tract 66 | 16,678
Liver and Pancreas 65 | 16,750
Skin and soft tissues 65 | 17,230
Cardiovascular System 63 | 15,192

Target Family

Enzyme 49 | 4,145
Non-IDG 19 | 12,091

Reactome Pathway

Regulation of RAS by GAPs 68 | 68
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
RAS protein activator like-3 RASAL3 Tbio Non-IDG -0.25123 2.81 57