Development Level

Tbio 48 | 11,445
Tchem 13 | 1,598
Tclin 5 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased circulating choleste... 2 | 93
increased lean body mass 2 | 172
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal glucose homeostasis 1 | 4
abnormal kidney morphology 1 | 65
absent testes 1 | 6
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased vertical activity 1 | 208
impaired glucose tolerance 1 | 75
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased lymphocyte cell numb... 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
long tibia 1 | 25
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
thrombocytosis 1 | 27

Disease

ovarian cancer 52 | 8,520
Carcinoma 34 | 11,493
lung cancer 33 | 4,740
Multiple myeloma 27 | 1,332
psoriasis 27 | 6,694
osteosarcoma 26 | 7,950
glioblastoma 23 | 5,792
Cancer 17 | 2,499
medulloblastoma, large-cell 16 | 6,241
HIV Infections 15 | 102
Breast cancer 14 | 3,578
atypical teratoid / rhabdoid tumor 12 | 5,112
dermatomyositis 12 | 966
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
adult high grade glioma 10 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
non-small cell lung cancer 10 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Waldenstrons macroglobulinemia 9 | 765
diabetes mellitus 9 | 1,728
ependymoma 9 | 4,679
subependymal giant cell astrocytoma 9 | 2,287
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
invasive ductal carcinoma 8 | 2,951
lung adenocarcinoma 8 | 2,716
malignant mesothelioma 8 | 3,232
oligodendroglioma 8 | 2,850
non primary Sjogren syndrome sicca 7 | 891
pancreatic cancer 7 | 2,398
Astrocytoma, Pilocytic 6 | 3,081
astrocytoma 6 | 1,146
lung carcinoma 6 | 2,843
Kidney cancer 5 | 2,613
Mantle cell lymphoma 5 | 23
Pick disease 5 | 1,894
acute myeloid leukemia 5 | 783
astrocytic glioma 5 | 2,597
group 4 medulloblastoma 5 | 1,855
juvenile dermatomyositis 5 | 1,187
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Anemia 4 | 365
Autosomal recessive predisposition 4 | 1,442
Carcinoma, Squamous Cell 4 | 110
Epilepsy 4 | 792
Intellectual disability 4 | 1,016
Liver Cirrhosis, Experimental 4 | 769
Osteoporosis 4 | 363
Seizures 4 | 596
Squamous cell carcinoma 4 | 129
primary Sjogren syndrome 4 | 735
Hepatomegaly 3 | 285
Mammary Neoplasms, Experimental 3 | 154
Obesity 3 | 678
Pick's disease 3 | 15
Skin Neoplasms 3 | 69
acute quadriplegic myopathy 3 | 1,158
interstitial cystitis 3 | 2,312
nasopharyngeal carcinoma 3 | 1,058
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
primitive neuroectodermal tumor 3 | 3,035
progressive supranuclear palsy 3 | 676
Alzheimer's disease 2 | 658
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Endometrial cancer 2 | 311
Hypertension 2 | 396
Hypothyroidism 2 | 122
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large intestine cancer 2 | 126
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Liver cancer 2 | 604
Macroglossia 2 | 65
Macrotia 2 | 87
Melanoma 2 | 711
Microstomia 2 | 78
Myocardial Ischemia 2 | 169
Parkinson's disease 2 | 392
Polycystic ovary syndrome 2 | 360
Polymicrogyria 2 | 48
Prostate cancer 2 | 175
Skin cancer 2 | 469
Vascular disease 2 | 319
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
hepatocellular carcinoma 2 | 547
pediatric high grade glioma 2 | 1,064
tuberculosis and treatment for 3 months 2 | 179

Tissue

Endocrine System 68 | 18,159
Blood and immune system 67 | 16,909
Digestive Tract 67 | 17,369
Female tissues 67 | 17,400
Male tissues 67 | 17,142
Nervous System 67 | 16,725
Respiratory system 67 | 16,393
Urinary Tract 67 | 16,678
Cardiovascular System 66 | 15,192
Liver and Pancreas 66 | 16,750
Skin and soft tissues 66 | 17,230

Target Family

Enzyme 49 | 4,145
Non-IDG 14 | 12,091
Kinase 6 | 634

Reactome Pathway

Regulation of PTEN stability a... 69 | 69
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Tyrosine-protein kinase FRK FRK Tchem Kinase -1.68365 49.2 394
E3 ubiquitin-protein ligase makorin-1 MKRN1 Tbio Enzyme -0.96099 16.4 225
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Putative protein SEM1, isoform 2 SEM1 Tbio Non-IDG 0.30 0.49 109