Development Level

Tbio 40 | 11,445
Tchem 12 | 1,598
Tclin 7 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to t... 5 | 278
embryonic lethality prior to o... 4 | 239
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
decreased body weight 3 | 161
decreased hemoglobin content 3 | 68
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
limb grasping 3 | 41
preweaning lethality, incomple... 3 | 499
abnormal gait 2 | 69
abnormal locomotor activation 2 | 16
abnormal startle reflex 2 | 15
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
edema 2 | 59
enlarged heart 2 | 210
hypoactivity 2 | 132
increased blood urea nitrogen ... 2 | 48
increased circulating amylase ... 2 | 25
increased circulating creatini... 2 | 38
increased circulating triglyce... 2 | 42
increased mean corpuscular hem... 2 | 96
increased startle reflex 2 | 112
small spleen 2 | 19
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
absent seminal vesicle 1 | 4
anophthalmia 1 | 33
aorta stenosis 1 | 2
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased lumbar vertebrae num... 1 | 2
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased sacral vertebrae num... 1 | 1
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased sacral vertebrae num... 1 | 1
male infertility 1 | 123
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small uterus 1 | 3
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Carcinoma 44 | 11,493
ovarian cancer 34 | 8,520
Cancer 28 | 2,499
osteosarcoma 28 | 7,950
medulloblastoma, large-cell 27 | 6,241
glioblastoma 25 | 5,792
psoriasis 21 | 6,694
Breast cancer 18 | 3,578
atypical teratoid / rhabdoid tumor 18 | 5,112
group 3 medulloblastoma 18 | 4,104
ependymoma 17 | 4,679
lung cancer 17 | 4,740
adult high grade glioma 14 | 3,801
primitive neuroectodermal tumor 14 | 3,035
Schizophrenia 13 | 1,160
Kidney cancer 12 | 2,613
oligodendroglioma 11 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
malignant mesothelioma 10 | 3,232
Multiple myeloma 9 | 1,332
breast carcinoma 9 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
invasive ductal carcinoma 9 | 2,951
Breast Neoplasms 8 | 445
Mammary Neoplasms 8 | 425
group 4 medulloblastoma 8 | 1,855
lung adenocarcinoma 8 | 2,716
non-small cell lung cancer 8 | 2,890
subependymal giant cell astrocytoma 8 | 2,287
Intellectual disability 7 | 1,016
Melanoma 7 | 711
Rheumatoid arthritis 7 | 1,191
Vascular disease 7 | 319
astrocytic glioma 7 | 2,597
astrocytoma 7 | 1,146
diabetes mellitus 7 | 1,728
ductal carcinoma in situ 7 | 1,745
pancreatic cancer 7 | 2,398
Astrocytoma, Pilocytic 6 | 3,081
Autosomal recessive predisposition 6 | 1,442
Colonic Neoplasms 6 | 142
Endometriosis 6 | 540
Epilepsy 6 | 792
Kidney disease 6 | 430
Lung Neoplasms 6 | 232
Neoplasm Invasiveness 6 | 161
Neoplasm Metastasis 6 | 168
Squamous cell carcinoma 6 | 129
Stomach Neoplasms 6 | 300
adrenocortical carcinoma 6 | 1,428
interstitial cystitis 6 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Asthma 5 | 385
Brain Ischemia 5 | 110
Carcinoma, Hepatocellular 5 | 228
Carcinoma, Squamous Cell 5 | 110
Endometrial cancer 5 | 311
Glioma 5 | 74
Hypertension 5 | 396
Hypertensive disease 5 | 292
Liver carcinoma 5 | 240
Obesity 5 | 678
Ovarian Neoplasms 5 | 102
Parkinson's disease 5 | 392
Peripheral T-cell lymphoma 5 | 25
Pick disease 5 | 1,894
Primary cutaneous T-cell lymphoma 5 | 29
Prostatic Neoplasms 5 | 495
acute quadriplegic myopathy 5 | 1,158
dermatomyositis 5 | 966
juvenile dermatomyositis 5 | 1,187
lung carcinoma 5 | 2,843
ovarian neoplasm 5 | 99
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Adenoma 4 | 167
Alzheimer's disease 4 | 658
Arthritis 4 | 290
Cocaine-Related Disorders 4 | 92
Cognitive delay 4 | 608
Dull intelligence 4 | 645
Global developmental delay 4 | 608
Heart disease 4 | 306
Liver neoplasms 4 | 130
Low intelligence 4 | 645
Lung disease 4 | 142
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Poor school performance 4 | 645
Reperfusion Injury 4 | 86
Seizures 4 | 596
Short stature 4 | 531
Skin cancer 4 | 469
Toxic encephalopathy 4 | 141
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 783
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
esophageal adenocarcinoma 4 | 737

Tissue

Endocrine System 60 | 18,159
Nervous System 60 | 16,725
Skin and soft tissues 60 | 17,230
Urinary Tract 60 | 16,678
Blood and immune system 59 | 16,909
Digestive Tract 59 | 17,369
Female tissues 59 | 17,400
Liver and Pancreas 59 | 16,750
Male tissues 59 | 17,142
Respiratory system 59 | 16,393
Cardiovascular System 58 | 15,192

Target Family

Non-IDG 22 | 12,091
Epigenetic 14 | 242
Transcription Factor 13 | 1,400
Enzyme 5 | 4,145
Kinase 3 | 634
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38
Transporter 1 | 473

Reactome Pathway

Regulation of PTEN gene transc... 61 | 61
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Transcription factor AP-1 JUN Tchem Transcription Factor -3.83935 6236.4 2664
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248