Development Level

Tbio 6 | 11,445
Tclin 6 | 613
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
increased blood urea nitrogen ... 1 | 48
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
preweaning lethality, incomple... 1 | 499
thrombocytopenia 1 | 56

Disease

Cancer 12 | 2,499
ovarian cancer 12 | 8,520
Carcinoma 11 | 11,493
osteosarcoma 10 | 7,950
medulloblastoma, large-cell 9 | 6,241
psoriasis 9 | 6,694
glioblastoma 8 | 5,792
Breast cancer 7 | 3,578
group 4 medulloblastoma 7 | 1,855
lung cancer 7 | 4,740
Blastic phase chronic myeloid leukemia 6 | 58
Chronic Myelocytic Leukemia Accelerated Phase 6 | 59
tuberculosis 6 | 2,010
Chronic phase chronic myeloid leukemia 5 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 5 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 5 | 47
atypical teratoid / rhabdoid tumor 5 | 5,112
cutaneous lupus erythematosus 5 | 1,057
ependymoma 5 | 4,679
invasive ductal carcinoma 5 | 2,951
juvenile dermatomyositis 5 | 1,187
pancreatic cancer 5 | 2,398
primary Sjogren syndrome 5 | 735
Astrocytoma, Pilocytic 4 | 3,081
Kidney cancer 4 | 2,613
Schizophrenia 4 | 1,160
astrocytoma 4 | 1,146
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Anemia 3 | 365
Chronic Lymphocytic Leukemia 3 | 262
Heart disease 3 | 306
Renal Cell Carcinoma 3 | 214
Stomach Neoplasms 3 | 300
Vitiligo 3 | 73
Waldenstrons macroglobulinemia 3 | 765
active ulcerative colitis 3 | 764
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
oligodendroglioma 3 | 2,850
pediatric high grade glioma 3 | 1,064
spina bifida 3 | 1,074
ulcerative colitis 3 | 1,819
Atopic dermatitis 2 | 952
Bipolar Disorder 2 | 666
Breast Neoplasms 2 | 445
Cardiomegaly 2 | 116
Cryptorchidism 2 | 296
Diarrhea 2 | 253
Down syndrome 2 | 499
Fatigue 2 | 182
Hepatitis C 2 | 94
Heterochromia iridis 2 | 9
Hyperpigmented macules 2 | 42
Increased gastric cancer 2 | 21
Liver Cirrhosis, Experimental 2 | 769
Lymphoproliferative syndrome 2 | 58
Mammary Neoplasms 2 | 425
Mastocytosis 2 | 27
Myocardial Infarction 2 | 151
Noonan syndrome 2 | 34
Peripheral vascular disease 2 | 87
Piebaldism 2 | 15
Rheumatoid arthritis 2 | 1,191
Sarcoma of soft tissue 2 | 11
Somatic mutation 2 | 61
Testicular Germ Cell Tumor 2 | 14
Testicular cancer 2 | 25
Ventricular Septal Defects 2 | 119
White forelock 2 | 12
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
colon cancer 2 | 1,478
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 807
hypopigmented skin patch 2 | 59
lung adenocarcinoma 2 | 2,716
mucosa-associated lymphoid tissue lymphoma 2 | 484
nasopharyngeal carcinoma 2 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
Acquired cubitus valgus 1 | 18
Curly hair (finding) 1 | 14
Dermatofibrosarcoma protuberans 1 | 15
Enlarged thorax 1 | 18
Gingival fibromatosis 1 | 14
Heart Septal Defects, Ventricular 1 | 6
Premature canities 1 | 24

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Kinase 7 | 634
Non-IDG 7 | 12,091
Enzyme 1 | 4,145

Reactome Pathway

Regulation of KIT signaling 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mast/stem cell growth factor receptor Kit KIT Tclin Kinase -3.80501 6371.9 4098
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Suppressor of cytokine signaling 1 SOCS1 Tbio Non-IDG -3.05851 1163.8 469
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
Suppressor of cytokine signaling 6 SOCS6 Tbio Non-IDG -1.92284 79.5 154
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147
SH2B adapter protein 3 SH2B3 Tbio Non-IDG -2.51914 340.6 151
Tyrosine-protein phosphatase non-receptor type 6 PTPN6 Tchem Enzyme -2.14628 178.2 684
SH2B adapter protein 2 SH2B2 Tbio Non-IDG -0.49192 2.51 0
Kit ligand KITLG Tbio Non-IDG -3.24306 1697.0 695