Development Level

Tbio 87 | 11,651
Tchem 26 | 1,388
Tclin 5 | 612
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, incomple... 7 | 499
abnormal seminal vesicle morph... 5 | 114
decreased bone mineral content 4 | 151
preweaning lethality, complete... 4 | 979
short tibia 4 | 97
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased vertical activity 3 | 208
enlarged heart 3 | 210
increased circulating alkaline... 3 | 122
increased circulating triglyce... 3 | 42
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal embryo size 2 | 220
abnormal kidney morphology 2 | 65
abnormal tooth morphology 2 | 24
decreased circulating glucose ... 2 | 126
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
increased blood urea nitrogen ... 2 | 48
increased leukocyte cell numbe... 2 | 47
increased total body fat amoun... 2 | 134
small superior vagus ganglion 2 | 74
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal femur morphology 1 | 14
abnormal head shape 1 | 10
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal liver morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal radius morphology 1 | 8
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
abnormal ulna morphology 1 | 8
abnormal urinary bladder morph... 1 | 11
absent startle reflex 1 | 24
absent testes 1 | 6
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
enlarged testis 1 | 6
enlarged uterus 1 | 11
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
limb grasping 1 | 41
pallor 1 | 34
premature death 1 | 5
prolonged PR interval 1 | 15
prolonged ST segment 1 | 36
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 84 | 11,493
ovarian cancer 77 | 8,520
psoriasis 69 | 6,694
glioblastoma 54 | 5,792
osteosarcoma 52 | 7,950
lung cancer 50 | 4,740
medulloblastoma, large-cell 49 | 6,241
Cancer 48 | 2,499
diabetes mellitus 47 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,955
atypical teratoid / rhabdoid tumor 44 | 5,112
malignant mesothelioma 44 | 3,232
ependymoma 43 | 4,679
pancreatic cancer 43 | 2,398
Breast cancer 42 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
invasive ductal carcinoma 39 | 2,951
lung carcinoma 39 | 2,843
cystic fibrosis 36 | 1,696
non-small cell lung cancer 36 | 2,890
Astrocytoma, Pilocytic 34 | 3,081
lung adenocarcinoma 34 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
ulcerative colitis 31 | 1,819
adult high grade glioma 30 | 3,801
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
Autosomal recessive predisposition 27 | 1,442
adrenocortical carcinoma 27 | 1,428
pituitary cancer 27 | 1,972
Kidney cancer 26 | 2,613
juvenile dermatomyositis 26 | 1,187
Atherosclerosis 25 | 291
primary pancreatic ductal adenocarcinoma 25 | 1,109
breast carcinoma 24 | 1,638
ductal carcinoma in situ 24 | 1,745
oligodendroglioma 24 | 2,850
tuberculosis 24 | 2,010
Duchenne muscular dystrophy 23 | 601
Kidney disease 23 | 430
interstitial cystitis 23 | 2,312
Hypertension 22 | 396
Liver disease 22 | 237
primitive neuroectodermal tumor 22 | 3,035
Coronary artery disease 21 | 268
Obesity 21 | 678
autosomal dominant Emery-Dreifuss muscular dystrophy 21 | 510
group 3 medulloblastoma 21 | 4,104
Liver Cirrhosis, Experimental 20 | 769
gastric carcinoma 20 | 807
Rheumatoid arthritis 19 | 1,191
pediatric high grade glioma 19 | 1,064
subependymal giant cell astrocytoma 19 | 2,287
esophageal adenocarcinoma 18 | 737
nasopharyngeal carcinoma 18 | 1,058
Heart disease 17 | 306
group 4 medulloblastoma 17 | 1,855
Endometriosis 16 | 540
Osteoporosis 16 | 363
acute quadriplegic myopathy 16 | 1,158
Atopic dermatitis 15 | 952
Cerebrovascular disease 15 | 238
Hypertensive disease 15 | 292
Liver Cirrhosis 15 | 181
Schizophrenia 15 | 1,160
active Crohn's disease 15 | 922
astrocytic glioma 15 | 2,597
colon cancer 15 | 1,478
Breast Neoplasms 14 | 445
Prostatic Neoplasms 14 | 495
Alzheimer's disease 13 | 658
Arthritis 13 | 290
Becker muscular dystrophy 13 | 191
Chemical and Drug Induced Liver Injury 13 | 195
Down syndrome 13 | 499
Mammary Neoplasms 13 | 425
Melanoma 13 | 711
astrocytoma 13 | 1,146
interstitial lung disease 13 | 298
limb girdle muscular dystrophy 2A 13 | 213
Bipolar Disorder 12 | 666
Pick disease 12 | 1,894
Vascular disease 12 | 319
dermatomyositis 12 | 966
Carcinoma, Hepatocellular 11 | 228
Liver carcinoma 11 | 240
Lung disease 11 | 142
cutaneous lupus erythematosus 11 | 1,057
fibroadenoma 11 | 559
Acute kidney injury 10 | 70
Anemia 10 | 365
Cardiovascular system disease 10 | 246
Lipid metabolism disorder 10 | 114
Polycystic ovary syndrome 10 | 360
Spontaneous abortion 10 | 113
Stomach Neoplasms 10 | 300
Thrombophilia 10 | 38
active ulcerative colitis 10 | 764
aldosterone-producing adenoma 10 | 665
medulloblastoma 10 | 720
non primary Sjogren syndrome sicca 10 | 891

Tissue

Endocrine System 121 | 18,159
Female tissues 117 | 17,400
Liver and Pancreas 117 | 16,750
Digestive Tract 116 | 17,369
Male tissues 116 | 17,142
Skin and soft tissues 115 | 17,230
Urinary Tract 114 | 16,678
Blood and immune system 113 | 16,909
Nervous System 110 | 16,725
Respiratory system 110 | 16,393
Cardiovascular System 100 | 15,192

Target Family

Non-IDG 96 | 12,091
Enzyme 26 | 4,145

Reactome Pathway

Regulation of Insulin-like Gro... 122 | 122
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Amelogenin, X isoform AMELX Tbio Non-IDG -2.84702 695.0 136
Secreted phosphoprotein 24 SPP2 Tbio Non-IDG -1.20992 21.1 29
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Bone morphogenetic protein 15 BMP15 Tbio Non-IDG -2.33917 221.7 200
Protein Z-dependent protease inhibitor SERPINA10 Tbio Enzyme -1.87106 72.9 218
Chordin-like protein 1 CHRDL1 Tbio Non-IDG -1.99743 97.9 191
Plasma alpha-L-fucosidase FUCA2 Tchem Enzyme -1.52925 32.6 227
Kallikrein-13 KLK13 Tbio Enzyme -1.25859 19.3 201
Secretogranin-3 SCG3 Tbio Non-IDG -1.59072 42.1 169
Nucleobindin-1 NUCB1 Tbio Non-IDG -2.75064 547.0 152