Development Level

Tbio 62 | 10,625
Tchem 13 | 1,890
Tdark 5 | 7,003
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 9 | 633
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
preweaning lethality, incomple... 2 | 260
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal iris morphology 1 | 12
abnormal joint morphology 1 | 14
abnormal maxilla morphology 1 | 16
abnormal optic disc morphology 1 | 10
abnormal placement of pupils 1 | 4
abnormal retinal pigmentation 1 | 61
abnormal skin coloration 1 | 18
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal tooth morphology 1 | 24
decreased bone mineral content 1 | 157
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15
short tibia 1 | 82
tremors 1 | 34

Disease

ovarian cancer 54 | 8,492
osteosarcoma 37 | 7,933
lung cancer 36 | 4,473
medulloblastoma, large-cell 35 | 6,234
glioblastoma 31 | 5,572
atypical teratoid / rhabdoid tumor 27 | 4,369
psoriasis 25 | 6,685
Breast cancer 23 | 3,099
Cancer 19 | 2,346
Pick disease 18 | 1,893
group 3 medulloblastoma 18 | 2,254
oligodendroglioma 18 | 2,849
pediatric high grade glioma 18 | 2,712
primitive neuroectodermal tumor 17 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
non-small cell lung cancer 16 | 2,798
dermatomyositis 15 | 967
malignant mesothelioma 15 | 3,163
astrocytic glioma 14 | 2,241
Carcinoma 13 | 2,147
Waldenstrons macroglobulinemia 13 | 765
invasive ductal carcinoma 13 | 2,950
Multiple myeloma 12 | 1,328
astrocytoma 12 | 1,493
diabetes mellitus 11 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
pilocytic astrocytoma 11 | 3,086
acute quadriplegic myopathy 10 | 1,157
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
lung adenocarcinoma 10 | 2,714
Rheumatoid Arthritis 9 | 1,171
colon cancer 9 | 1,475
ependymoma 9 | 2,514
interstitial cystitis 9 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
Parkinson's disease 8 | 364
breast carcinoma 8 | 1,614
ductal carcinoma in situ 8 | 1,745
esophageal adenocarcinoma 8 | 737
group 4 medulloblastoma 8 | 1,875
pancreatic cancer 8 | 2,300
posterior fossa group B ependymoma 8 | 1,530
sonic hedgehog group medulloblastoma 8 | 1,482
subependymal giant cell astrocytoma 8 | 2,287
Vascular disease 7 | 281
adult high grade glioma 7 | 2,148
atypical teratoid/rhabdoid tumor 7 | 1,095
non primary Sjogren syndrome sicca 7 | 840
pituitary cancer 7 | 1,972
spina bifida 7 | 1,064
tuberculosis and treatment for 6 months 7 | 686
ulcerative colitis 7 | 2,087
Alzheimer's disease 6 | 644
HIV Infections 6 | 100
Prostatic Neoplasms 6 | 471
cystic fibrosis 6 | 1,670
juvenile dermatomyositis 6 | 1,189
lung carcinoma 6 | 2,844
medulloblastoma 6 | 1,524
tuberculosis 6 | 1,563
Amyotrophic Lateral Sclerosis 5 | 432
Stomach Neoplasms 5 | 282
posterior fossa group A ependymoma 5 | 1,511
Arthritis 4 | 248
Atopic dermatitis 4 | 944
Huntington's disease 4 | 72
IGA Glomerulonephritis 4 | 454
Kidney disease 4 | 397
Mammary Neoplasms 4 | 410
Toxic encephalopathy 4 | 131
active Crohn's disease 4 | 918
acute myeloid leukemia 4 | 785
adrenocortical carcinoma 4 | 1,427
fibroadenoma 4 | 557
hepatocellular carcinoma 4 | 550
hereditary spastic paraplegia 4 | 313
progressive supranuclear palsy 4 | 674
tuberculosis and treatment for 3 months 4 | 327
Ataxia telangiectasia 3 | 32
Atherosclerosis 3 | 275
Ceroid lipofuscinosis, neuronal, 6 3 | 7
Down syndrome 3 | 548
Gliosis 3 | 16
Heart disease 3 | 279
Hypersensitivity reaction type II disease 3 | 235
Liver carcinoma 3 | 217
Myocardial Infarction 3 | 126
Neoplasm Metastasis 3 | 138
Nijmegen breakage syndrome 3 | 23
Obesity 3 | 616
Squamous cell carcinoma 3 | 96
Streptococcal pneumonia 3 | 6
aldosterone-producing adenoma 3 | 664
chronic rhinosinusitis 3 | 512
cutaneous lupus erythematosus 3 | 1,056
cystic fibrosis and chronic rhinosinusitis 3 | 213
interstitial lung disease 3 | 292
nasopharyngeal carcinoma 3 | 1,056
pancreatic carcinoma 3 | 567
primary pancreatic ductal adenocarcinoma 3 | 1,271

Tissue

Blood and immune system 80 | 17,995
Endocrine System 80 | 18,512
Female tissues 80 | 18,647
Liver and Pancreas 80 | 18,136
Nervous System 80 | 18,561
Cardiovascular System 79 | 17,958
Digestive Tract 79 | 18,473
Male tissues 79 | 17,969
Skin and soft tissues 79 | 18,115
Urinary Tract 79 | 18,444
Respiratory system 78 | 17,484

Target Family

Non-IDG 69 | 11,969
Kinase 6 | 634
Enzyme 3 | 4,146
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Regulation of HSF1-mediated he... 81 | 81
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear pore complex protein Nup133 NUP133 Tbio Non-IDG -1.34399 21.9 72
Peptidyl-prolyl cis-trans isomerase FKBP4 FKBP4 Tchem Enzyme -2.68233 516.8 409
BAG family molecular chaperone regulator 3 BAG3 Tbio Non-IDG -2.19746 181.8 254
BAG family molecular chaperone regulator 2 BAG2 Tbio Non-IDG -1.99998 101.1 202
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.46324 281.9 299
Heat shock-related 70 kDa protein 2 HSPA2 Tbio Non-IDG -1.97802 99.5 138
MAP kinase-activated protein kinase 2 MAPKAPK2 Tchem Kinase -2.14428 135.6 649
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.11484 12.8 160
Nuclear pore glycoprotein p62 NUP62 Tbio Non-IDG -1.75221 57.4 221
Polyubiquitin-B UBB Tbio Non-IDG -1.96206 92.3 370