Development Level

Tbio 48 | 10,625
Tchem 21 | 1,890
Tclin 5 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 7 | 633
abnormal epididymis morphology 1 | 31
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
cataract 1 | 26
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
decreased circulating insulin ... 1 | 75
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
increased grip strength 1 | 83
prenatal lethality prior to he... 1 | 64
small testis 1 | 37

Disease

ovarian cancer 54 | 8,484
lung cancer 39 | 4,466
psoriasis 38 | 6,685
osteosarcoma 34 | 7,933
glioblastoma 31 | 5,572
Multiple myeloma 30 | 1,327
Cancer 25 | 2,346
malignant mesothelioma 25 | 3,162
medulloblastoma, large-cell 25 | 6,234
non-small cell lung cancer 21 | 2,798
Breast cancer 18 | 3,094
group 3 medulloblastoma 17 | 2,254
HIV Infections 16 | 100
adrenocortical carcinoma 16 | 1,427
atypical teratoid / rhabdoid tumor 16 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
lung adenocarcinoma 15 | 2,713
primitive neuroectodermal tumor 15 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
pediatric high grade glioma 14 | 2,712
dermatomyositis 13 | 933
Waldenstrons macroglobulinemia 12 | 765
invasive ductal carcinoma 12 | 2,950
oligodendroglioma 11 | 2,849
astrocytoma 10 | 1,493
nasopharyngeal carcinoma 10 | 1,056
posterior fossa group A ependymoma 10 | 1,511
colon cancer 9 | 1,475
primary Sjogren syndrome 8 | 789
Atopic dermatitis 7 | 944
Endometriosis 7 | 535
Meier-Gorlin syndrome 7 | 12
ductal carcinoma in situ 7 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
pancreatic cancer 7 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
subependymal giant cell astrocytoma 7 | 2,287
EAR, PATELLA, SHORT STATURE SYNDROME 6 | 6
juvenile dermatomyositis 6 | 1,189
medulloblastoma 6 | 1,524
non primary Sjogren syndrome sicca 6 | 840
pilocytic astrocytoma 6 | 3,086
ulcerative colitis 6 | 2,087
Mantle cell lymphoma 5 | 18
Pick disease 5 | 1,893
Seckel syndrome 5 | 34
astrocytic glioma 5 | 2,241
breast carcinoma 5 | 1,614
diabetes mellitus 5 | 1,663
inflammatory breast cancer 5 | 404
primary pancreatic ductal adenocarcinoma 5 | 1,271
tuberculosis 5 | 1,557
Liver carcinoma 4 | 217
Peripheral Neuropathy 4 | 303
Squamous cell carcinoma of esophagus 4 | 82
active Crohn's disease 4 | 918
atypical teratoid/rhabdoid tumor 4 | 1,095
cutaneous lupus erythematosus 4 | 1,056
ependymoma 4 | 2,514
esophageal adenocarcinoma 4 | 737
interstitial cystitis 4 | 2,299
lung carcinoma 4 | 2,844
Animal Mammary Neoplasms 3 | 136
Bladder Neoplasm 3 | 109
IGA Glomerulonephritis 3 | 454
Mammary Neoplasms 3 | 410
Mammary Neoplasms, Experimental 3 | 150
Microcephaly 3 | 149
Polycystic Ovary Syndrome 3 | 332
Rheumatoid Arthritis 3 | 1,160
acute myeloid leukemia 3 | 780
acute quadriplegic myopathy 3 | 1,157
adult high grade glioma 3 | 2,148
cystic fibrosis 3 | 1,665
gastric cancer 3 | 430
gastric carcinoma 3 | 832
pituitary cancer 3 | 1,972
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 6 months 3 | 686
Adenoma 2 | 165
Alzheimer's disease 2 | 644
Colonic Neoplasms 2 | 126
Duchenne muscular dystrophy 2 | 602
Intestinal Neoplasms 2 | 11
Kidney Diseases 2 | 86
Liver neoplasms 2 | 109
Lung Neoplasms 2 | 171
Melanoma 2 | 261
Osteoporosis 2 | 257
Pick's disease 2 | 14
Prostatic Neoplasms 2 | 471
Pulmonary emphysema 2 | 34
Sezary Syndrome 2 | 26
Stevens-Johnson syndrome 2 | 78
Stomach Neoplasms 2 | 282
chronic kidney disease 2 | 90
glioblastoma multiforme 2 | 347
hepatocellular carcinoma 2 | 532
sonic hedgehog group medulloblastoma 2 | 1,482
substance-related disorder 2 | 105

Tissue

Blood and immune system 75 | 17,995
Digestive Tract 75 | 18,473
Endocrine System 75 | 18,512
Female tissues 75 | 18,647
Liver and Pancreas 75 | 18,136
Male tissues 75 | 17,969
Nervous System 75 | 18,561
Urinary Tract 75 | 18,444
Cardiovascular System 74 | 17,958
Respiratory system 74 | 17,484
Skin and soft tissues 74 | 18,115

Target Family

Enzyme 42 | 4,146
Non-IDG 29 | 11,971
Transcription Factor 3 | 1,400
Kinase 1 | 634

Reactome Pathway

Regulation of DNA replication 75 | 75
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43357 2997.4 1177
Origin recognition complex subunit 4 ORC4 Tbio Non-IDG -1.49781 32.5 130
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50789 31.4 61
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.80641 78.9 225
Fizzy-related protein homolog FZR1 Tbio Non-IDG -1.74457 58.7 182
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.83653 71.4 158
DNA replication licensing factor MCM3 MCM3 Tbio Non-IDG -2.00856 94.2 378