Development Level

Tbio 51 | 10,625
Tchem 20 | 1,890
Tclin 5 | 602
Tdark 3 | 7,003

IMPC Term

preweaning lethality, complete... 10 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 4 | 187
abnormal embryo size 3 | 112
embryonic growth retardation 3 | 28
anophthalmia 2 | 20
abnormal bone structure 1 | 131
abnormal craniofacial morpholo... 1 | 12
abnormal forebrain morphology 1 | 4
abnormal head shape 1 | 4
abnormal hindbrain morphology 1 | 2
abnormal midbrain morphology 1 | 2
abnormal neural tube closure 1 | 37
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal skin coloration 1 | 18
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating glucose ... 1 | 121
decreased lean body mass 1 | 195
edema 1 | 11
improved glucose tolerance 1 | 56
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
microphthalmia 1 | 15
pallor 1 | 13
prenatal lethality 1 | 16
urinary bladder obstruction 1 | 2

Disease

ovarian cancer 58 | 8,484
psoriasis 37 | 6,685
lung cancer 35 | 4,466
glioblastoma 33 | 5,572
osteosarcoma 32 | 7,933
Multiple myeloma 29 | 1,327
medulloblastoma, large-cell 23 | 6,234
Cancer 21 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
Breast cancer 17 | 3,094
malignant mesothelioma 17 | 3,162
invasive ductal carcinoma 16 | 2,950
non-small cell lung cancer 16 | 2,798
HIV Infections 15 | 100
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
pediatric high grade glioma 15 | 2,712
atypical teratoid / rhabdoid tumor 14 | 4,369
lung adenocarcinoma 13 | 2,713
Waldenstrons macroglobulinemia 12 | 765
adrenocortical carcinoma 12 | 1,427
dermatomyositis 12 | 933
pancreatic cancer 11 | 2,300
posterior fossa group A ependymoma 11 | 1,511
primitive neuroectodermal tumor 11 | 3,031
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
astrocytoma 9 | 1,493
breast carcinoma 9 | 1,614
colon cancer 9 | 1,475
oligodendroglioma 9 | 2,849
primary Sjogren syndrome 9 | 789
Atopic dermatitis 8 | 944
Endometriosis 8 | 535
ductal carcinoma in situ 8 | 1,745
group 3 medulloblastoma 8 | 2,254
non primary Sjogren syndrome sicca 8 | 840
sonic hedgehog group medulloblastoma 8 | 1,482
IGA Glomerulonephritis 7 | 454
Pick disease 7 | 1,893
astrocytic glioma 7 | 2,241
diabetes mellitus 7 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
medulloblastoma 7 | 1,524
pilocytic astrocytoma 7 | 3,086
ulcerative colitis 7 | 2,087
active Crohn's disease 6 | 918
ependymoma 6 | 2,514
esophageal adenocarcinoma 6 | 737
interstitial cystitis 6 | 2,299
nasopharyngeal carcinoma 6 | 1,056
Mantle cell lymphoma 5 | 18
acute quadriplegic myopathy 5 | 1,157
atypical teratoid/rhabdoid tumor 5 | 1,095
lung carcinoma 5 | 2,844
primary pancreatic ductal adenocarcinoma 5 | 1,271
subependymal giant cell astrocytoma 5 | 2,287
Squamous cell carcinoma of esophagus 4 | 82
cutaneous lupus erythematosus 4 | 1,056
juvenile dermatomyositis 4 | 1,189
pituitary cancer 4 | 1,972
tuberculosis 4 | 1,557
Osteoporosis 3 | 257
Peripheral Neuropathy 3 | 303
Polycystic Ovary Syndrome 3 | 332
acute myeloid leukemia 3 | 780
inflammatory breast cancer 3 | 404
progressive supranuclear palsy 3 | 674
Acquired metabolic disease 2 | 267
Alzheimer's disease 2 | 644
Animal Mammary Neoplasms 2 | 136
Duchenne muscular dystrophy 2 | 602
MOSAIC VARIEGATED ANEUPLOIDY SYNDROME 2 | 4
Mammary Neoplasms, Experimental 2 | 150
Myofibrillar myopathy 1 2 | 5
Myofibrillar myopathy 3 2 | 4
Parkinson's disease 2 | 364
Pick's disease 2 | 14
Rheumatoid Arthritis 2 | 1,160
Stevens-Johnson syndrome 2 | 78
adult high grade glioma 2 | 2,148
chronic kidney disease 2 | 90
cystic fibrosis 2 | 1,665
group 4 medulloblastoma 2 | 1,875
hepatocellular carcinoma 2 | 532
sarcoidosis 2 | 358
tuberculosis and treatment for 6 months 2 | 686
Amyotrophic Lateral Sclerosis 1 | 431
Bladder Neoplasm 1 | 109
Cockayne syndrome 1 | 54
Degenerative polyarthritis 1 | 93
Exophthalmos 1 | 16
Fetal valproate syndrome 1 | 4
Liver carcinoma 1 | 217
Liver neoplasms 1 | 109
Microcephaly 1 | 149
Patau syndrome 1 | 15
cystic fibrosis and chronic rhinosinusitis 1 | 213
limb girdle muscular dystrophy 2B 1 | 74
non-small cell lung carcinoma 1 | 413
substance-related disorder 1 | 105
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 79 | 17,995
Digestive Tract 79 | 18,473
Endocrine System 79 | 18,512
Female tissues 79 | 18,647
Liver and Pancreas 79 | 18,136
Male tissues 79 | 17,969
Nervous System 79 | 18,561
Urinary Tract 79 | 18,444
Cardiovascular System 78 | 17,958
Respiratory system 78 | 17,484
Skin and soft tissues 78 | 18,115

Target Family

Enzyme 50 | 4,146
Non-IDG 25 | 11,971
Kinase 4 | 634

Reactome Pathway

Regulation of APC/C activators... 79 | 79
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Ubiquitin-conjugating enzyme E2 E1 UBE2E1 Tbio Non-IDG -1.18305 12.0 72
Anaphase-promoting complex subunit 15 ANAPC15 Tdark Enzyme -0.41378 2.22 21
Anaphase-promoting complex subunit CDC26 CDC26 Tbio Enzyme -0.67669 4.56 45
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.80641 78.9 225
Fizzy-related protein homolog FZR1 Tbio Non-IDG -1.74457 58.7 182
Anaphase-promoting complex subunit 10 ANAPC10 Tbio Enzyme -1.23667 18.1 141