Development Level

Tbio 16 | 11,178
Tchem 9 | 1,885
Tclin 1 | 612
Tdark 1 | 6,569

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal seminal vesicle morph... 1 | 114
absent pinna reflex 1 | 23
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased grip strength 1 | 116
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
female infertility 1 | 60
hydrometra 1 | 53
hypoactivity 1 | 132
increased circulating free fat... 1 | 20
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74

Disease

Carcinoma 25 | 11,192
ovarian cancer 22 | 8,297
glioblastoma 14 | 5,635
psoriasis 14 | 6,514
atypical teratoid / rhabdoid tumor 13 | 4,971
medulloblastoma, large-cell 13 | 6,086
osteosarcoma 13 | 7,766
Breast cancer 11 | 3,469
adult high grade glioma 11 | 3,701
ependymoma 11 | 4,559
Cancer 10 | 2,388
Kidney cancer 10 | 2,548
group 3 medulloblastoma 10 | 4,002
Astrocytoma, Pilocytic 9 | 3,006
lung cancer 9 | 4,607
astrocytic glioma 8 | 2,530
oligodendroglioma 8 | 2,768
subependymal giant cell astrocytoma 8 | 2,230
lung carcinoma 7 | 2,755
primitive neuroectodermal tumor 7 | 2,957
invasive ductal carcinoma 6 | 2,867
malignant mesothelioma 6 | 3,135
pancreatic cancer 6 | 2,322
pituitary cancer 6 | 1,915
tuberculosis 6 | 1,963
Coffin-Lowry syndrome 5 | 9
Dull intelligence 5 | 634
Epilepsy 5 | 775
Intellectual disability 5 | 998
Low intelligence 5 | 634
Mental Retardation 5 | 634
Mental deficiency 5 | 634
Pick disease 5 | 1,856
Poor school performance 5 | 634
active ulcerative colitis 5 | 736
acute quadriplegic myopathy 5 | 1,133
ductal carcinoma in situ 5 | 1,686
interstitial cystitis 5 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,204
Multiple myeloma 4 | 1,296
Renal Cell Carcinoma 4 | 211
Seizures 4 | 584
active Crohn's disease 4 | 882
colon cancer 4 | 1,428
group 4 medulloblastoma 4 | 1,806
lung adenocarcinoma 4 | 2,627
Amyotrophic lateral sclerosis 3 | 437
Becker muscular dystrophy 3 | 184
Cataract 8 multiple types 3 | 33
Congenital nystagmus 3 | 26
Degenerative polyarthritis 3 | 110
Down syndrome 3 | 480
Duchenne muscular dystrophy 3 | 587
Liver cancer 3 | 589
Muscle hypotonia 3 | 562
Neoplasm Invasiveness 3 | 151
Neoplasm Metastasis 3 | 160
Neurodegenerative disease 3 | 402
Neurofibromatosis 3 | 40
Osteoarthritis 3 | 179
Osteoporosis 3 | 348
Rheumatoid arthritis 3 | 1,156
Schizophrenia 3 | 1,136
Short stature 3 | 514
Small head 3 | 366
Vascular disease 3 | 294
Waldenstrons macroglobulinemia 3 | 742
breast carcinoma 3 | 1,589
dermatomyositis 3 | 941
diabetes mellitus 3 | 1,683
gastric cancer 3 | 445
juvenile dermatomyositis 3 | 1,147
non-small cell lung cancer 3 | 2,799
pancreatic carcinoma 3 | 555
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,911
Alzheimer's disease 2 | 640
Arthritis 2 | 276
Arthritis, Juvenile 2 | 123
Bilateral fifth finger clinodactyly 2 | 109
Bipolar Disorder 2 | 646
Curvature of little finger 2 | 109
Delayed speech and language development 2 | 110
Endometriosis 2 | 521
Juvenile arthritis 2 | 123
Language Delay 2 | 110
Multiple Sclerosis 2 | 527
Speech Delay 2 | 110
Speech impairment 2 | 110
acute myeloid leukemia 2 | 760
adrenocortical carcinoma 2 | 1,385
aldosterone-producing adenoma 2 | 646
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 492
cystic fibrosis 2 | 1,629
esophageal adenocarcinoma 2 | 696
gastric carcinoma 2 | 781
primary pancreatic ductal adenocarcinoma 2 | 1,071
progressive supranuclear palsy 2 | 656
urothelial carcinoma 2 | 303

Tissue

Endocrine System 27 | 18,159
Blood and immune system 26 | 16,909
Cardiovascular System 26 | 15,192
Digestive Tract 26 | 17,369
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Nervous System 26 | 16,725
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678

Target Family

Non-IDG 18 | 12,091
Kinase 8 | 634
Enzyme 1 | 4,145

Reactome Pathway

Recycling pathway of L1 27 | 27
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ribosomal protein S6 kinase alpha-2 RPS6KA2 Tchem Kinase -2.17609 136.7 406
Ribosomal protein S6 kinase alpha-1 RPS6KA1 Tchem Kinase -2.57872 338.0 1158
Chromosome-associated kinesin KIF4A KIF4A Tchem Non-IDG -1.91717 78.0 157
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Radixin RDX Tbio Non-IDG -2.47844 221.4 333
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Chromosome-associated kinesin KIF4B KIF4B Tbio Non-IDG 0.01 1.04 3
Dynamin-1 DNM1 Tbio Non-IDG -2.67692 450.0 464