Development Level

Tbio 18 | 10,625
Tchem 9 | 1,890
Tclin 1 | 602

IMPC Term

abnormal behavior 2 | 226
decreased mean corpuscular vol... 2 | 50
abnormal bone structure 1 | 131
abnormal femur morphology 1 | 14
absent pinna reflex 1 | 21
decreased NK T cell number 1 | 28
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating fructosa... 1 | 31
decreased circulating serum al... 1 | 79
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
embryonic lethality prior to t... 1 | 187
female infertility 1 | 34
hypoactivity 1 | 89
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased sacral vertebrae num... 1 | 62
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82

Disease

ovarian cancer 23 | 8,484
glioblastoma 15 | 5,572
osteosarcoma 14 | 7,933
psoriasis 14 | 6,685
medulloblastoma, large-cell 13 | 6,234
atypical teratoid / rhabdoid tumor 12 | 4,369
Breast cancer 10 | 3,094
Cancer 10 | 2,346
pediatric high grade glioma 10 | 2,712
lung cancer 9 | 4,466
oligodendroglioma 9 | 2,849
pilocytic astrocytoma 9 | 3,086
subependymal giant cell astrocytoma 9 | 2,287
ependymoma 7 | 2,514
lung carcinoma 7 | 2,844
primitive neuroectodermal tumor 7 | 3,031
Pick disease 6 | 1,893
astrocytic glioma 6 | 2,241
invasive ductal carcinoma 6 | 2,950
malignant mesothelioma 6 | 3,162
pancreatic cancer 6 | 2,300
pituitary cancer 6 | 1,972
tuberculosis 6 | 1,557
Carcinoma 5 | 2,147
Coffin-Lowry syndrome 5 | 10
acute quadriplegic myopathy 5 | 1,157
ductal carcinoma in situ 5 | 1,745
group 4 medulloblastoma 5 | 1,875
interstitial cystitis 5 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
posterior fossa group B ependymoma 5 | 1,530
Alzheimer's disease 4 | 644
Multiple myeloma 4 | 1,327
Rheumatoid Arthritis 4 | 1,160
Vascular disease 4 | 281
active Crohn's disease 4 | 918
active ulcerative colitis 4 | 477
astrocytoma 4 | 1,493
colon cancer 4 | 1,475
diabetes mellitus 4 | 1,663
group 3 medulloblastoma 4 | 2,254
lung adenocarcinoma 4 | 2,713
sonic hedgehog group medulloblastoma 4 | 1,482
Amyotrophic Lateral Sclerosis 3 | 431
Becker muscular dystrophy 3 | 187
Congenital nystagmus 3 | 26
Degenerative polyarthritis 3 | 93
Down syndrome 3 | 548
Duchenne muscular dystrophy 3 | 602
Neoplasm Invasiveness 3 | 127
Neurofibromatosis 3 | 37
Osteoporosis 3 | 257
Renal Cell Carcinoma 3 | 199
Waldenstrons macroglobulinemia 3 | 765
breast carcinoma 3 | 1,614
dermatomyositis 3 | 933
gastric carcinoma 3 | 832
juvenile dermatomyositis 3 | 1,189
non-small cell lung cancer 3 | 2,798
pancreatic carcinoma 3 | 567
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
ulcerative colitis 3 | 2,087
Arthritis 2 | 248
Cocaine-Related Disorders 2 | 88
Endometriosis 2 | 535
Epilepsy 2 | 346
Gastrointestinal stromal tumor 2 | 61
Gastrointestinal system disease 2 | 50
Hemorrhoid 2 | 3
IGA Glomerulonephritis 2 | 454
Intellectual disability 2 | 573
Juvenile arthritis 2 | 124
Kindler syndrome 2 | 10
Multiple Sclerosis 2 | 498
Neoplasm Metastasis 2 | 138
Neurodegenerative disease 2 | 383
Neuropathy 2 | 210
Pancreatic Neuroendocrine Tumor 2 | 45
Platelet mean volume finding 2 | 31
Polycystic Ovary Syndrome 2 | 332
Sezary Syndrome 2 | 26
acute myeloid leukemia 2 | 780
adrenocortical carcinoma 2 | 1,427
aldosterone-producing adenoma 2 | 664
atypical teratoid/rhabdoid tumor 2 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
cystic fibrosis 2 | 1,665
esophageal adenocarcinoma 2 | 737
gastric cancer 2 | 430
hereditary spastic paraplegia 2 | 313
interstitial lung disease 2 | 291
medulloblastoma 2 | 1,524
posterior fossa group A ependymoma 2 | 1,511
primary pancreatic ductal adenocarcinoma 2 | 1,271
progressive supranuclear palsy 2 | 674
tuberculosis and treatment for 6 months 2 | 686
urothelial carcinoma 2 | 318
Blood pressure finding 1 | 56

Tissue

Blood and immune system 28 | 17,995
Cardiovascular System 28 | 17,958
Digestive Tract 28 | 18,473
Endocrine System 28 | 18,512
Female tissues 28 | 18,647
Liver and Pancreas 28 | 18,136
Male tissues 28 | 17,969
Nervous System 28 | 18,561
Respiratory system 28 | 17,484
Skin and soft tissues 28 | 18,115
Urinary Tract 28 | 18,444

Target Family

Non-IDG 19 | 11,971
Kinase 8 | 634
Enzyme 1 | 4,146

Reactome Pathway

Recycling pathway of L1 28 | 28
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Radixin RDX Tbio Non-IDG -2.45592 216.9 310
Shootin-1 SHTN1 Tbio Non-IDG -0.97772 9.81 24
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.46968 311.2 390
Dynamin-2 DNM2 Tchem Non-IDG -3.22299 1426.1 125
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.63932 4.63 109
Moesin MSN Tbio Non-IDG -2.57842 339.5 426
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.74208 55.9 226
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.23666 21.2 139
Dynamin-3 DNM3 Tbio Non-IDG -1.39674 21.9 126
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.12872 1138.1 1044