Development Level

Tbio 51 | 10,625
Tchem 14 | 1,890
Tdark 11 | 7,003
Tclin 3 | 602

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 633
decreased body weight 4 | 174
abnormal head morphology 3 | 10
decreased total body fat amoun... 3 | 186
embryonic lethality prior to t... 3 | 187
abnormal cranium morphology 2 | 32
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating calcium ... 2 | 33
decreased circulating choleste... 2 | 85
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
increased circulating alkaline... 2 | 119
abnormal behavior 1 | 226
abnormal external female genit... 1 | 1
abnormal external male genital... 1 | 1
abnormal femur morphology 1 | 14
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal tail movements 1 | 12
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
decreased basophil cell number 1 | 11
decreased body length 1 | 108
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating fructosa... 1 | 31
decreased circulating sodium l... 1 | 18
decreased effector memory CD4-... 1 | 6
decreased eosinophil cell numb... 1 | 41
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
enlarged lymph nodes 1 | 27
hypoactivity 1 | 89
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased grip strength 1 | 83
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
male infertility 1 | 62
urinary bladder obstruction 1 | 2
vertebral fusion 1 | 23

Disease

ovarian cancer 54 | 8,491
osteosarcoma 43 | 7,933
psoriasis 33 | 6,685
medulloblastoma, large-cell 31 | 6,234
glioblastoma 25 | 5,572
atypical teratoid / rhabdoid tumor 24 | 4,369
lung cancer 24 | 4,473
malignant mesothelioma 24 | 3,163
primitive neuroectodermal tumor 23 | 3,031
group 3 medulloblastoma 22 | 2,254
oligodendroglioma 20 | 2,849
ependymoma 19 | 2,514
Breast cancer 17 | 3,098
Carcinoma 17 | 2,147
Pick disease 17 | 1,893
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
colon cancer 16 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
non-small cell lung cancer 16 | 2,798
pediatric high grade glioma 16 | 2,712
Microcephaly 14 | 149
Intellectual disability 13 | 573
astrocytic glioma 13 | 2,241
Multiple myeloma 12 | 1,327
lung adenocarcinoma 12 | 2,714
nasopharyngeal carcinoma 12 | 1,056
pilocytic astrocytoma 12 | 3,086
sonic hedgehog group medulloblastoma 12 | 1,482
Cancer 11 | 2,346
posterior fossa group B ependymoma 11 | 1,530
atypical teratoid/rhabdoid tumor 10 | 1,095
breast carcinoma 10 | 1,614
invasive ductal carcinoma 10 | 2,950
pancreatic cancer 10 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
ulcerative colitis 9 | 2,087
subependymal giant cell astrocytoma 8 | 2,287
Waldenstrons macroglobulinemia 7 | 764
adrenocortical carcinoma 7 | 1,427
diabetes mellitus 7 | 1,663
ductal carcinoma in situ 7 | 1,745
juvenile dermatomyositis 7 | 1,189
tuberculosis 7 | 1,563
tuberculosis and treatment for 6 months 7 | 686
Obesity 6 | 616
Seckel syndrome 6 | 35
adult high grade glioma 6 | 2,148
astrocytoma 6 | 1,493
dermatomyositis 6 | 966
non primary Sjogren syndrome sicca 6 | 840
pituitary cancer 6 | 1,972
posterior fossa group A ependymoma 6 | 1,511
progressive supranuclear palsy 6 | 674
Bardet-Biedl Syndrome 5 | 40
Joubert syndrome 5 | 62
Lissencephaly 5 | 61
Nephronophthisis 5 | 74
Rheumatoid Arthritis 5 | 1,170
Schizophrenia 5 | 503
acute myeloid leukemia 5 | 785
group 4 medulloblastoma 5 | 1,875
Amyotrophic Lateral Sclerosis 4 | 432
Atopic dermatitis 4 | 944
Ciliopathy 4 | 57
Duchenne muscular dystrophy 4 | 602
Endometriosis 4 | 535
Miller-Dieker lissencephaly syndrome 4 | 20
Neuroblastoma 4 | 78
Neurodegenerative disease 4 | 383
Senior-Loken syndrome 4 | 22
acute quadriplegic myopathy 4 | 1,157
chronic rhinosinusitis 4 | 512
interstitial cystitis 4 | 2,299
medulloblastoma 4 | 1,524
pancreatic carcinoma 4 | 567
Down syndrome 3 | 548
Gaucher disease type 1 3 | 171
Gestational trophoblastic neoplasia 3 | 14
HER2-positive carcinoma of breast 3 | 10
Kaposi's sarcoma 3 | 20
Liposarcoma 3 | 20
Malignant tumor of head and/or neck 3 | 15
Malignant tumor of ovary 3 | 25
Metastatic Prostate Carcinoma 3 | 18
Nephroblastoma 3 | 45
Open-angle glaucoma 3 | 26
Renal Cell Carcinoma 3 | 199
Rhabdomyosarcoma 3 | 29
Secondary malignant neoplasm of pancreas 3 | 10
Sensorineural hearing loss 3 | 107
Usher syndrome 3 | 34
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
esophageal adenocarcinoma 3 | 737
hepatocellular carcinoma 3 | 550
hereditary spastic paraplegia 3 | 313
primary Sjogren syndrome 3 | 788
primary pancreatic ductal adenocarcinoma 3 | 1,271
spina bifida 3 | 1,064
transitional cell carcinoma 3 | 20

Tissue

Blood and immune system 79 | 17,994
Cardiovascular System 79 | 17,957
Endocrine System 79 | 18,511
Female tissues 79 | 18,646
Male tissues 79 | 17,968
Nervous System 79 | 18,560
Digestive Tract 78 | 18,472
Liver and Pancreas 78 | 18,135
Urinary Tract 78 | 18,443
Respiratory system 77 | 17,483
Skin and soft tissues 77 | 18,114

Target Family

Non-IDG 66 | 11,969
Kinase 9 | 634
Enzyme 4 | 4,146

Reactome Pathway

Recruitment of mitotic centros... 79 | 79
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HAUS augmin-like complex subunit 8 HAUS8 Tbio Non-IDG 1.00 0.07 117
HAUS augmin-like complex subunit 7 HAUS7 Tbio Non-IDG -0.21560 1.53 128
HAUS augmin-like complex subunit 2 HAUS2 Tdark Non-IDG 1.15 0.07 35
Centrosomal protein of 41 kDa CEP41 Tdark Non-IDG -0.38839 3.35 44
Centrosomal protein of 131 kDa CEP131 Tbio Non-IDG -1.75708 61.0 81
Gamma-tubulin complex component 5 TUBGCP5 Tbio Non-IDG -0.80629 5.44 87
Centrosome-associated protein CEP250 CEP250 Tbio Non-IDG -0.66723 5.22 14
Gamma-tubulin complex component 6 TUBGCP6 Tbio Non-IDG -0.69093 4.86 78
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.73539 525.6 142
Centriolar coiled-coil protein of 110 kDa CCP110 Tbio Non-IDG -1.43015 25.5 104