Development Level

Tbio 40 | 10,625
Tchem 9 | 1,890
Tdark 6 | 7,003
Tclin 1 | 602

IMPC Phenotype

abnormal behavior 2 | 226
decreased body length 2 | 108
decreased body weight 2 | 174
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating total pr... 2 | 41
preweaning lethality, complete... 2 | 633
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coat-hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal gait 1 | 51
abnormal posture 1 | 5
abnormal rib morphology 1 | 28
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
decreased KLRG1-positive NK ce... 1 | 9
decreased circulating alkaline... 1 | 41
decreased circulating triglyce... 1 | 83
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
hydrops fetalis 1 | 22
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating creatini... 1 | 29
increased circulating sodium l... 1 | 71
increased effector memory CD4-... 1 | 15
increased monocyte cell number 1 | 27
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
preweaning lethality, incomple... 1 | 260
small adrenal glands 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 31 | 8,491
osteosarcoma 28 | 7,933
Cancer 23 | 2,346
lung cancer 19 | 4,473
Breast cancer 17 | 3,098
psoriasis 16 | 6,685
glioblastoma 13 | 5,572
medulloblastoma, large-cell 13 | 6,234
malignant mesothelioma 11 | 3,163
Carcinoma 10 | 2,147
lung adenocarcinoma 10 | 2,714
sonic hedgehog group medulloblastoma 10 | 1,482
Mammary Neoplasms 9 | 410
Nijmegen breakage syndrome 9 | 23
atypical teratoid / rhabdoid tumor 9 | 4,369
invasive ductal carcinoma 9 | 2,950
Ataxia telangiectasia 8 | 32
Neoplastic Syndromes, Hereditary 8 | 48
breast carcinoma 8 | 1,614
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
lung carcinoma 8 | 2,844
non-small cell lung cancer 8 | 2,798
oligodendroglioma 8 | 2,849
Multiple myeloma 7 | 1,327
Pick disease 7 | 1,893
astrocytoma 7 | 1,493
ependymoma 7 | 2,514
group 3 medulloblastoma 7 | 2,254
pancreatic cancer 7 | 2,300
pituitary cancer 7 | 1,972
primitive neuroectodermal tumor 7 | 3,031
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 2,087
Alzheimer's disease 6 | 644
Hereditary Breast and Ovarian Cancer Syndrome 6 | 14
astrocytic glioma 6 | 2,241
Amyotrophic Lateral Sclerosis 5 | 432
Fanconi's anemia 5 | 50
Malignant neoplasm of breast 5 | 63
Prostatic Neoplasms 5 | 471
Waldenstrons macroglobulinemia 5 | 764
atypical teratoid/rhabdoid tumor 5 | 1,095
nasopharyngeal carcinoma 5 | 1,056
pediatric high grade glioma 5 | 2,712
progressive supranuclear palsy 5 | 674
Breast Cancer, Familial 4 | 12
Neurodegenerative disease 4 | 383
Stomach Neoplasms 4 | 282
acute myeloid leukemia 4 | 785
adult high grade glioma 4 | 2,148
colon cancer 4 | 1,475
cutaneous lupus erythematosus 4 | 1,056
cystic fibrosis 4 | 1,670
diabetes mellitus 4 | 1,663
group 4 medulloblastoma 4 | 1,875
non-small cell lung carcinoma 4 | 413
pilocytic astrocytoma 4 | 3,086
tuberculosis 4 | 1,563
Adenoid Cystic Carcinoma 3 | 99
Cleft palate 3 | 125
Colorectal Neoplasms 3 | 217
Immune system cancer 3 | 38
Intellectual disability 3 | 573
Li-Fraumeni syndrome 3 | 13
Microcephaly 3 | 149
Neoplastic Cell Transformation 3 | 81
Pancreatic Neoplasm 3 | 79
Prostate cancer 3 | 172
Prostate cancer, familial 3 | 13
Renal Cell Carcinoma 3 | 199
Rheumatoid Arthritis 3 | 1,170
Seckel syndrome 3 | 35
Stomach cancer 3 | 18
Williams-Beuren syndrome 3 | 45
adrenocortical carcinoma 3 | 1,427
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
non primary Sjogren syndrome sicca 3 | 840
posterior fossa group A ependymoma 3 | 1,511
posterior fossa group B ependymoma 3 | 1,530
tuberculosis and treatment for 6 months 3 | 686
Endometriosis 2 | 535
Eye disease 2 | 55
Kidney disease 2 | 397
Lung disease 2 | 136
Male infertility 2 | 170
Malignant neoplasm of prostate 2 | 67
Neuroblastoma 2 | 78
Peripheral Neuropathy 2 | 303
Vascular disease 2 | 281
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
dermatomyositis 2 | 966
glioblastoma multiforme 2 | 347
hepatocellular carcinoma 2 | 550
inflammatory breast cancer 2 | 404
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
spina bifida 2 | 1,064

Tissue

Blood and immune system 56 | 17,994
Cardiovascular System 56 | 17,957
Digestive Tract 56 | 18,472
Endocrine System 56 | 18,511
Female tissues 56 | 18,646
Male tissues 56 | 17,968
Nervous System 56 | 18,560
Urinary Tract 56 | 18,443
Liver and Pancreas 55 | 18,135
Respiratory system 55 | 17,483
Skin and soft tissues 52 | 18,114

Target Family

Non-IDG 39 | 11,969
Enzyme 6 | 4,146
Epigenetic 5 | 242
Kinase 4 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

Recruitment and ATM-mediated p... 56 | 56
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Tumor suppressor p53-binding protein 1 TP53BP1 Tbio Epigenetic -2.65153 422.5 514
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.69416 474.2 685
Lysine-specific demethylase 4B KDM4B Tchem Epigenetic -1.51013 36.7 415
BRCA1-A complex subunit Abraxas FAM175A Tbio Non-IDG -0.78687 4.54 144
Histone H2B type 1-O HIST1H2BO Tdark Non-IDG -0.27142 0.81 50
Ubiquitin carboxyl-terminal hydrolase BAP1 BAP1 Tbio Enzyme -2.03345 107.2 280