Development Level

Tbio 40 | 10,625
Tchem 9 | 1,890
Tdark 6 | 7,003
Tclin 1 | 602

IMPC Term

abnormal behavior 2 | 226
decreased body length 2 | 108
decreased body weight 2 | 174
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating total pr... 2 | 41
preweaning lethality, complete... 2 | 633
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal gait 1 | 51
abnormal posture 1 | 5
abnormal rib morphology 1 | 28
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
decreased KLRG1-positive NK ce... 1 | 9
decreased circulating alkaline... 1 | 41
decreased circulating triglyce... 1 | 83
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
hydrops fetalis 1 | 22
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating creatini... 1 | 29
increased circulating sodium l... 1 | 71
increased effector memory CD4-... 1 | 15
increased monocyte cell number 1 | 27
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
preweaning lethality, incomple... 1 | 260
small adrenal glands 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 31 | 8,492
osteosarcoma 28 | 7,933
Cancer 23 | 2,346
lung cancer 19 | 4,473
Breast cancer 17 | 3,099
psoriasis 16 | 6,685
glioblastoma 13 | 5,572
medulloblastoma, large-cell 13 | 6,234
malignant mesothelioma 11 | 3,163
Carcinoma 10 | 2,147
lung adenocarcinoma 10 | 2,714
sonic hedgehog group medulloblastoma 10 | 1,482
Mammary Neoplasms 9 | 410
Nijmegen breakage syndrome 9 | 23
atypical teratoid / rhabdoid tumor 9 | 4,369
invasive ductal carcinoma 9 | 2,950
Ataxia telangiectasia 8 | 32
Neoplastic Syndromes, Hereditary 8 | 48
breast carcinoma 8 | 1,614
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
lung carcinoma 8 | 2,844
non-small cell lung cancer 8 | 2,798
oligodendroglioma 8 | 2,849
Multiple myeloma 7 | 1,328
Pick disease 7 | 1,893
astrocytoma 7 | 1,493
ependymoma 7 | 2,514
group 3 medulloblastoma 7 | 2,254
pancreatic cancer 7 | 2,300
pituitary cancer 7 | 1,972
primitive neuroectodermal tumor 7 | 3,031
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 2,087
Alzheimer's disease 6 | 644
Hereditary Breast and Ovarian Cancer Syndrome 6 | 14
astrocytic glioma 6 | 2,241
Amyotrophic Lateral Sclerosis 5 | 432
Fanconi's anemia 5 | 50
Malignant neoplasm of breast 5 | 63
Prostatic Neoplasms 5 | 471
Waldenstrons macroglobulinemia 5 | 765
atypical teratoid/rhabdoid tumor 5 | 1,095
nasopharyngeal carcinoma 5 | 1,056
pediatric high grade glioma 5 | 2,712
progressive supranuclear palsy 5 | 674
Breast Cancer, Familial 4 | 12
Neurodegenerative disease 4 | 383
Stomach Neoplasms 4 | 282
acute myeloid leukemia 4 | 785
adult high grade glioma 4 | 2,148
colon cancer 4 | 1,475
cutaneous lupus erythematosus 4 | 1,056
cystic fibrosis 4 | 1,670
diabetes mellitus 4 | 1,663
group 4 medulloblastoma 4 | 1,875
non-small cell lung carcinoma 4 | 413
pilocytic astrocytoma 4 | 3,086
tuberculosis 4 | 1,563
Adenoid Cystic Carcinoma 3 | 99
Cleft palate 3 | 125
Colorectal Neoplasms 3 | 217
Immune system cancer 3 | 38
Intellectual disability 3 | 573
Li-Fraumeni syndrome 3 | 13
Microcephaly 3 | 149
Neoplastic Cell Transformation 3 | 81
Pancreatic Neoplasm 3 | 79
Prostate cancer 3 | 172
Prostate cancer, familial 3 | 13
Renal Cell Carcinoma 3 | 199
Rheumatoid Arthritis 3 | 1,171
Seckel syndrome 3 | 35
Stomach cancer 3 | 18
Williams-Beuren syndrome 3 | 45
adrenocortical carcinoma 3 | 1,427
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
non primary Sjogren syndrome sicca 3 | 840
posterior fossa group A ependymoma 3 | 1,511
posterior fossa group B ependymoma 3 | 1,530
tuberculosis and treatment for 6 months 3 | 686
Endometriosis 2 | 535
Eye disease 2 | 55
Kidney disease 2 | 397
Lung disease 2 | 136
Male infertility 2 | 170
Malignant neoplasm of prostate 2 | 67
Neuroblastoma 2 | 78
Peripheral Neuropathy 2 | 303
Vascular disease 2 | 281
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
dermatomyositis 2 | 967
glioblastoma multiforme 2 | 347
hepatocellular carcinoma 2 | 550
inflammatory breast cancer 2 | 404
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
spina bifida 2 | 1,064

Tissue

Blood and immune system 56 | 17,995
Cardiovascular System 56 | 17,958
Digestive Tract 56 | 18,473
Endocrine System 56 | 18,512
Female tissues 56 | 18,647
Male tissues 56 | 17,969
Nervous System 56 | 18,561
Urinary Tract 56 | 18,444
Liver and Pancreas 55 | 18,136
Respiratory system 55 | 17,484
Skin and soft tissues 52 | 18,115

Target Family

Non-IDG 39 | 11,969
Enzyme 6 | 4,146
Epigenetic 5 | 242
Kinase 4 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

Recruitment and ATM-mediated p... 56 | 56
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase BAZ1B BAZ1B Tbio Epigenetic -1.42830 30.5 140
BRCA1-associated RING domain protein 1 BARD1 Tbio Non-IDG -2.06127 111.2 208
Polyubiquitin-C UBC Tbio Non-IDG -2.87696 56.7 130
Polyubiquitin-B UBB Tbio Non-IDG -1.96206 92.3 370
SUMO-conjugating enzyme UBC9 UBE2I Tbio Non-IDG -2.43451 254.0 306
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
BRCA1-A complex subunit RAP80 UIMC1 Tbio Non-IDG -1.68357 49.7 167
BRISC and BRCA1-A complex member 1 BABAM1 Tbio Non-IDG -1.19070 16.2 115