Development Level

Tbio 44 | 11,445
Tchem 8 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
decreased body weight 2 | 161
preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal vocalization 1 | 21
corneal opacity 1 | 32
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased body length 1 | 32
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
long tibia 1 | 25
small adrenal glands 1 | 16
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 38 | 11,493
ovarian cancer 30 | 8,520
osteosarcoma 27 | 7,950
Cancer 23 | 2,499
lung cancer 22 | 4,740
Breast cancer 19 | 3,578
glioblastoma 16 | 5,792
psoriasis 16 | 6,694
group 3 medulloblastoma 14 | 4,104
medulloblastoma, large-cell 14 | 6,241
atypical teratoid / rhabdoid tumor 13 | 5,112
malignant mesothelioma 13 | 3,232
breast carcinoma 12 | 1,638
ependymoma 12 | 4,679
lung adenocarcinoma 11 | 2,716
non-small cell lung cancer 11 | 2,890
Ataxia telangiectasia 10 | 34
Breast Neoplasms 10 | 445
Mammary Neoplasms 10 | 425
Nijmegen breakage syndrome 10 | 24
invasive ductal carcinoma 10 | 2,951
Kidney cancer 9 | 2,613
ductal carcinoma in situ 9 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Multiple myeloma 8 | 1,332
adult high grade glioma 8 | 3,801
astrocytic glioma 8 | 2,597
lung carcinoma 8 | 2,843
oligodendroglioma 8 | 2,850
subependymal giant cell astrocytoma 8 | 2,287
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Pick disease 7 | 1,894
Schizophrenia 7 | 1,160
Short stature 7 | 531
pancreatic cancer 7 | 2,398
pituitary cancer 7 | 1,972
primitive neuroectodermal tumor 7 | 3,035
Alzheimer's disease 6 | 658
Amyotrophic lateral sclerosis 6 | 451
Autosomal recessive predisposition 6 | 1,442
Cleft Palate 6 | 271
Intellectual disability 6 | 1,016
Prostatic Neoplasms 6 | 495
ulcerative colitis 6 | 1,819
Astrocytoma, Pilocytic 5 | 3,081
Dull intelligence 5 | 645
Fanconi anemia 5 | 56
Hypoplastic mandible condyle 5 | 275
Low intelligence 5 | 645
Mandibular hypoplasia 5 | 275
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Micrognathism 5 | 275
Pancreatic Neoplasm 5 | 85
Poor school performance 5 | 645
Stomach Neoplasms 5 | 300
Waldenstrons macroglobulinemia 5 | 765
colon cancer 5 | 1,478
nasopharyngeal carcinoma 5 | 1,058
progressive supranuclear palsy 5 | 676
Anemia 4 | 365
Cell Transformation, Neoplastic 4 | 97
Chromosome Breakage 4 | 36
Epilepsy 4 | 792
Liver cancer 4 | 604
Microcephaly 4 | 166
Neoplastic Cell Transformation 4 | 89
Neurodegenerative disease 4 | 414
Pancreatic Neoplasms 4 | 85
Seizures 4 | 596
Small head 4 | 374
Strabismus 4 | 270
Uranostaphyloschisis 4 | 167
Xeroderma pigmentosum 4 | 43
adrenocortical carcinoma 4 | 1,428
astrocytoma 4 | 1,146
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
group 4 medulloblastoma 4 | 1,855
Adenoid Cystic Carcinoma 3 | 99
Attention deficit hyperactivity disorder 3 | 278
Bladder Neoplasm 3 | 112
Carcinoma, Adenoid Cystic 3 | 99
Colonic Neoplasms 3 | 142
Depressive disorder 3 | 409
Lung Neoplasms 3 | 232
Male infertility 3 | 206
Melanoma 3 | 711
Muscle Spasticity 3 | 195
Polycystic ovary syndrome 3 | 360
Precursor Cell Lymphoblastic Leukemia-Lymphoma 3 | 49
Prostate cancer 3 | 175
acute myeloid leukemia 3 | 783
diabetes mellitus 3 | 1,728
gastric carcinoma 3 | 807
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
medulloblastoma 3 | 720
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Endocrine System 55 | 18,159
Blood and immune system 54 | 16,909
Cardiovascular System 54 | 15,192
Digestive Tract 54 | 17,369
Female tissues 54 | 17,400
Liver and Pancreas 54 | 16,750
Male tissues 54 | 17,142
Nervous System 54 | 16,725
Respiratory system 54 | 16,393
Skin and soft tissues 54 | 17,230
Urinary Tract 54 | 16,678

Target Family

Non-IDG 38 | 12,091
Enzyme 6 | 4,145
Epigenetic 5 | 242
Kinase 3 | 634
Transcription Factor 2 | 1,400
TF/Epigenetic 1 | 38

Reactome Pathway

Recruitment and ATM-mediated p... 55 | 55
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Tyrosine-protein kinase BAZ1B BAZ1B Tbio Epigenetic -1.45627 32.0 155
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Histone H2B type 1-H HIST1H2BH Tbio Non-IDG 0.16 0.59 55
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53