Development Level

Tbio 24 | 11,445
Tchem 3 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 4 | 239
decreased circulating triglyce... 2 | 79
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal pharyngeal arch morph... 1 | 8
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
limb grasping 1 | 41
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 20 | 8,520
Carcinoma 15 | 11,493
lung cancer 15 | 4,740
group 3 medulloblastoma 14 | 4,104
malignant mesothelioma 14 | 3,232
psoriasis 14 | 6,694
medulloblastoma, large-cell 13 | 6,241
atypical teratoid / rhabdoid tumor 11 | 5,112
glioblastoma 11 | 5,792
osteosarcoma 11 | 7,950
primitive neuroectodermal tumor 11 | 3,035
non-small cell lung cancer 9 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
adult high grade glioma 7 | 3,801
ependymoma 7 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Breast cancer 6 | 3,578
oligodendroglioma 6 | 2,850
Cancer 5 | 2,499
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 783
astrocytoma 5 | 1,146
nasopharyngeal carcinoma 5 | 1,058
Short stature 4 | 531
adrenocortical carcinoma 4 | 1,428
astrocytic glioma 4 | 2,597
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
lung adenocarcinoma 4 | 2,716
Aplastic Anemia 3 | 21
Chronic Lymphocytic Leukemia 3 | 262
Colorectal Neoplasms 3 | 243
Hyperkyphosis 3 | 111
Hypoplastic mandible condyle 3 | 275
Kidney cancer 3 | 2,613
Kyphosis deformity of spine 3 | 114
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Multiple myeloma 3 | 1,332
Xeroderma pigmentosum 3 | 43
dermatomyositis 3 | 966
group 4 medulloblastoma 3 | 1,855
invasive ductal carcinoma 3 | 2,951
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
Acquired flat foot 2 | 72
Acquired scoliosis 2 | 281
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 30
Alzheimer's disease 2 | 658
Anemia 2 | 365
Autosomal recessive predisposition 2 | 1,442
Bilateral fifth finger clinodactyly 2 | 110
Blepharophimosis 2 | 70
Broad forehead 2 | 59
Coarse facial features 2 | 108
Cockayne syndrome 2 | 60
Colonic Neoplasms 2 | 142
Congenital pes cavus 2 | 88
Curvature of little finger 2 | 110
Curvature of spine 2 | 282
Dull intelligence 2 | 645
Endometriosis 2 | 540
Epilepsy 2 | 792
Familial adenomatous polyposis 2 | 32
Flatfoot 2 | 73
Full lower lip 2 | 64
Hernia, Inguinal 2 | 89
Hypogonadism 2 | 173
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Lynch syndrome 2 | 35
Macroglossia 2 | 65
Macrostomia 2 | 72
Malignant tumor of ovary 2 | 25
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Metastatic Breast Carcinoma 2 | 21
Muscle hypotonia 2 | 571
Obesity 2 | 678
Open Bite 2 | 21
Pick's disease 2 | 15
Poor school performance 2 | 645
Prominent lower lip 2 | 64
Relative macrocephaly 2 | 12
Seckel syndrome 2 | 34
Seizures 2 | 596
Sensorineural Hearing Loss (disorder) 2 | 284
Sloping shoulders 2 | 21
Thickened facial skin with coarse facial features 2 | 108
Tremor 2 | 113
acute quadriplegic myopathy 2 | 1,158
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
juvenile dermatomyositis 2 | 1,187
lung carcinoma 2 | 2,843
pancreatic cancer 2 | 2,398
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
spina bifida 2 | 1,074

Tissue

Blood and immune system 30 | 16,909
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678
Cardiovascular System 28 | 15,192

Target Family

Non-IDG 18 | 12,091
Enzyme 11 | 4,145
Transcription Factor 1 | 1,400

Reactome Pathway

Recognition of DNA damage by P... 30 | 30
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Zinc finger and BTB domain-containing protein 32 ZBTB32 Tbio Transcription Factor -2.17117 142.7 132
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.36589 20.3 293
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.30866 19.7 176
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139