Development Level

Tbio 7 | 11,445
Tchem 7 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal duodenum morphology 1 | 4
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
cataract 1 | 92
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
preweaning lethality, complete... 1 | 979
short tibia 1 | 97

Disease

atypical teratoid / rhabdoid tumor 10 | 5,112
glioblastoma 10 | 5,792
medulloblastoma, large-cell 10 | 6,241
Carcinoma 9 | 11,493
adult high grade glioma 9 | 3,801
ependymoma 9 | 4,679
lung adenocarcinoma 8 | 2,716
oligodendroglioma 8 | 2,850
osteosarcoma 8 | 7,950
ovarian cancer 8 | 8,520
astrocytic glioma 7 | 2,597
malignant mesothelioma 7 | 3,232
primitive neuroectodermal tumor 7 | 3,035
Astrocytoma, Pilocytic 6 | 3,081
Cancer 6 | 2,499
cystic fibrosis 5 | 1,696
invasive ductal carcinoma 5 | 2,951
lung cancer 5 | 4,740
non-small cell lung cancer 5 | 2,890
psoriasis 5 | 6,694
Breast cancer 4 | 3,578
Parkinson's disease 4 | 392
adrenocortical carcinoma 4 | 1,428
group 3 medulloblastoma 4 | 4,104
group 4 medulloblastoma 4 | 1,855
lung carcinoma 4 | 2,843
primary pancreatic ductal adenocarcinoma 4 | 1,109
Abnormal dermatoglyphic pattern 3 | 24
Acquired scoliosis 3 | 281
Asthma 3 | 385
Blepharoptosis 3 | 231
Byzanthine arch palate 3 | 194
Crohn's disease 3 | 321
Curvature of spine 3 | 282
Joint hyperflexibility 3 | 78
Muscle hypotonia 3 | 571
Short stature 3 | 531
Strabismus 3 | 270
colon cancer 3 | 1,478
diabetes mellitus 3 | 1,728
interstitial cystitis 3 | 2,312
pancreatic cancer 3 | 2,398
Aortic coarctation 2 | 30
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Bowed and upward slanting eyebrows 2 | 41
Cerebral atrophy 2 | 178
Chronic Lymphocytic Leukemia 2 | 262
Cleft Palate 2 | 271
Conductive hearing loss 2 | 123
Congenital hemivertebra 2 | 25
Decreased size of teeth 2 | 62
Decreased width of tooth 2 | 59
Dilated ventricles (finding) 2 | 121
Down syndrome 2 | 499
Epistaxis 2 | 43
Failure to gain weight 2 | 365
Feeding difficulties 2 | 127
Heart Septal Defects 2 | 24
Heart disease 2 | 306
Hemangioma 2 | 69
Hydrocephalus 2 | 152
Hypodontia 2 | 81
Hypoplasia of columella 2 | 7
Kabuki syndrome 2 | 27
Kidney cancer 2 | 2,613
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Long eyelashes 2 | 37
Macrotia 2 | 87
Melanoma 2 | 711
Microdontia (disorder) 2 | 59
Multiple myeloma 2 | 1,332
Pediatric failure to thrive 2 | 365
Pick disease 2 | 1,894
Prominent ear 2 | 56
Protruding ears 2 | 56
Recurrent infections 2 | 48
Sensorineural Hearing Loss (disorder) 2 | 284
Short columella 2 | 7
Short fifth finger 2 | 9
Small head 2 | 374
Stormorken syndrome 2 | 6
Thick, flared eyebrows 2 | 41
Uranostaphyloschisis 2 | 167
Waldenstrons macroglobulinemia 2 | 765
Widely spaced teeth 2 | 31
cutaneous lupus erythematosus 2 | 1,057
ductal carcinoma in situ 2 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
medulloblastoma 2 | 720
pituitary cancer 2 | 1,972
sarcoidosis 2 | 370
ulcerative colitis 2 | 1,819

Tissue

Endocrine System 15 | 18,159
Male tissues 15 | 17,142
Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 4 | 4,145
Kinase 4 | 634

Reactome Pathway

Rap1 signalling 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Rap guanine nucleotide exchange factor 4 RAPGEF4 Tchem Non-IDG -2.46995 289.7 118
RAS guanyl-releasing protein 2 RASGRP2 Tbio Non-IDG -1.23693 18.9 108
RAS guanyl-releasing protein 1 RASGRP1 Tchem Non-IDG -1.99263 105.6 99
Rap1 GTPase-activating protein 2 RAP1GAP2 Tbio Enzyme -0.51757 3.72 24
Rap1 GTPase-activating protein 1 RAP1GAP Tbio Enzyme -1.86555 64.9 168
Signal-induced proliferation-associated protein 1 SIPA1 Tbio Non-IDG -1.32939 22.0 209
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.59435 390.4 689
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.70325 459.4 238
Ras-related protein Rap-1A RAP1A Tchem Enzyme -2.40799 294.7 329