Development Level

Tbio 106 | 11,445
Tdark 13 | 6,588
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 8 | 979
increased circulating alkaline... 4 | 122
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased mean corpuscular hem... 3 | 50
hydrometra 3 | 53
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal sleep behavior 2 | 70
cataract 2 | 92
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal motor capabilities-co... 1 | 5
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal spinal cord morpholog... 1 | 9
decreased B cell number 1 | 5
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
female infertility 1 | 60
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating thyroxin... 1 | 7
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
limb grasping 1 | 41
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
prolonged RR interval 1 | 8
short tibia 1 | 97
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 71 | 11,493
ovarian cancer 71 | 8,520
osteosarcoma 69 | 7,950
medulloblastoma, large-cell 46 | 6,241
psoriasis 40 | 6,694
glioblastoma 39 | 5,792
atypical teratoid / rhabdoid tumor 31 | 5,112
ependymoma 27 | 4,679
lung cancer 27 | 4,740
adult high grade glioma 26 | 3,801
Kidney cancer 22 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
lung carcinoma 20 | 2,843
malignant mesothelioma 19 | 3,232
Pick disease 18 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
tuberculosis 18 | 2,010
Astrocytoma, Pilocytic 17 | 3,081
invasive ductal carcinoma 17 | 2,951
astrocytoma 16 | 1,146
group 3 medulloblastoma 15 | 4,104
interstitial cystitis 15 | 2,312
subependymal giant cell astrocytoma 15 | 2,287
Multiple myeloma 14 | 1,332
non-small cell lung cancer 14 | 2,890
Breast cancer 13 | 3,578
group 4 medulloblastoma 13 | 1,855
lung adenocarcinoma 12 | 2,716
oligodendroglioma 12 | 2,850
Epilepsy 11 | 792
acute quadriplegic myopathy 11 | 1,158
astrocytic glioma 11 | 2,597
pancreatic cancer 11 | 2,398
primary pancreatic ductal adenocarcinoma 11 | 1,109
Intellectual disability 10 | 1,016
dermatomyositis 10 | 966
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
pituitary cancer 10 | 1,972
primitive neuroectodermal tumor 10 | 3,035
spina bifida 10 | 1,074
Autosomal recessive predisposition 9 | 1,442
Cancer 9 | 2,499
Hermansky-Pudlak syndrome 9 | 42
Rheumatoid arthritis 9 | 1,191
juvenile dermatomyositis 9 | 1,187
Seizures 8 | 596
breast carcinoma 8 | 1,638
ductal carcinoma in situ 8 | 1,745
Choroideremia 7 | 16
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Neurodegenerative disease 7 | 414
Waldenstrons macroglobulinemia 7 | 765
Warburg micro syndrome 7 | 18
acute myeloid leukemia 7 | 783
non primary Sjogren syndrome sicca 7 | 891
ulcerative colitis 7 | 1,819
Acquired scoliosis 6 | 281
Alzheimer's disease 6 | 658
Curvature of spine 6 | 282
Dull intelligence 6 | 645
Griscelli syndrome 6 | 24
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Muscle hypotonia 6 | 571
Poor school performance 6 | 645
aldosterone-producing adenoma 6 | 665
colon cancer 6 | 1,478
diabetes mellitus 6 | 1,728
gastric carcinoma 6 | 807
pediatric high grade glioma 6 | 1,064
sonic hedgehog group medulloblastoma 6 | 467
Cataract 5 | 297
Gaucher disease type 1 5 | 180
Lissencephaly 5 | 69
Microcephaly 5 | 166
Muscle Spasticity 5 | 195
Neuropathy 5 | 261
Oculocerebrorenal syndrome 5 | 29
Optic Atrophy 5 | 242
Small head 5 | 374
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
hepatocellular carcinoma 5 | 547
hereditary spastic paraplegia 5 | 318
nasopharyngeal carcinoma 5 | 1,058
Anteverted nostril 4 | 191
Byzanthine arch palate 4 | 194
Lens Opacities 4 | 231
Myocardial Ischemia 4 | 169
Schizophrenia 4 | 1,160
Short nose 4 | 132
Small nose 4 | 132
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
gastric cancer 4 | 459
posterior fossa group B ependymoma 4 | 416

Tissue

Blood and immune system 123 | 16,909
Digestive Tract 123 | 17,369
Endocrine System 123 | 18,159
Female tissues 123 | 17,400
Liver and Pancreas 123 | 16,750
Male tissues 123 | 17,142
Respiratory system 123 | 16,393
Skin and soft tissues 123 | 17,230
Urinary Tract 123 | 16,678
Cardiovascular System 122 | 15,192
Nervous System 122 | 16,725

Target Family

Non-IDG 78 | 12,091
Enzyme 43 | 4,145
Kinase 3 | 634

Reactome Pathway

Rab regulation of trafficking 124 | 124
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
MAP kinase-activating death domain protein MADD Tbio Enzyme -1.86555 79.6 121
DENN domain-containing protein 2A DENND2A Tbio Non-IDG 0.00000 34
Ras-related protein Rab-39A RAB39A Tdark Enzyme -0.57787 3.49 68
TBC1 domain family member 13 TBC1D13 Tdark Non-IDG -0.10266 1.34 92
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
Trafficking protein particle complex subunit 8 TRAPPC8 Tdark Non-IDG -1.08378 10.2 5
Suppression of tumorigenicity 5 protein ST5 Tbio Non-IDG -2.14294 141.9 161
Ankyrin repeat domain-containing protein 27 ANKRD27 Tbio Non-IDG -1.12548 14.6 65