Development Level

Tbio 4 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

abnormal locomotor behavior 1 | 24
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 6 | 11,493
Cancer 5 | 2,499
atypical teratoid / rhabdoid tumor 5 | 5,112
ovarian cancer 5 | 8,520
Breast cancer 4 | 3,578
Hypertensive disease 4 | 292
glioblastoma 4 | 5,792
malignant mesothelioma 4 | 3,232
osteosarcoma 4 | 7,950
pancreatic cancer 4 | 2,398
Adenocarcinoma 3 | 122
Astrocytoma, Pilocytic 3 | 3,081
Carcinoma, Hepatocellular 3 | 228
Colorectal Neoplasms 3 | 243
Kidney cancer 3 | 2,613
Kidney disease 3 | 430
Liver disease 3 | 237
Lung Neoplasms 3 | 232
Pancreatic Neoplasm 3 | 85
Pancreatic Neoplasms 3 | 85
Prostatic Neoplasms 3 | 495
Stomach Neoplasms 3 | 300
adult high grade glioma 3 | 3,801
diabetes mellitus 3 | 1,728
ependymoma 3 | 4,679
interstitial cystitis 3 | 2,312
lung cancer 3 | 4,740
psoriasis 3 | 6,694
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Acquired scoliosis 2 | 281
Acute kidney injury 2 | 70
Adenoma 2 | 167
Anemia 2 | 365
Aortic Valve Insufficiency 2 | 40
Atrial Fibrillation 2 | 124
Biliary tract cancer 2 | 19
Carcinoma, Squamous Cell 2 | 110
Cell Transformation, Neoplastic 2 | 97
Cerebrovascular disease 2 | 238
Chest Pain 2 | 38
Cholangiocarcinoma 2 | 35
Class III malocclusion 2 | 78
Congenital Camptodactyly 2 | 40
Congenital deafness 2 | 185
Coronary artery disease 2 | 268
Craniofacial Abnormalities 2 | 151
Curvature of spine 2 | 282
DOID:9917 2 | 31
Deafness 2 | 198
Decreased joint mobility 2 | 53
Diabetes Mellitus, Experimental 2 | 108
Endometrial cancer 2 | 311
Epilepsy 2 | 792
Esophageal Neoplasms 2 | 69
Esophageal carcinoma 2 | 16
Familial adenomatous polyposis 2 | 32
Headache 2 | 37
Hearing Loss, Partial 2 | 185
Hypertension 2 | 396
Hypertrophy of lower jaw 2 | 78
Increased risk of pancreatic cancer 2 | 9
Increased size of mandible 2 | 78
Inflammatory bowel disease 2 | 151
Liver Cirrhosis 2 | 181
Liver Cirrhosis, Experimental 2 | 769
Liver Neoplasms, Experimental 2 | 59
Liver cancer 2 | 604
Liver carcinoma 2 | 240
Lung disease 2 | 142
Malignant neoplasm of pancreas 2 | 9
Mandibular hyperplasia 2 | 78
Muscular Diseases 2 | 27
Myocardial Infarction 2 | 151
Myopathy 2 | 185
Neoplasm Metastasis 2 | 168
Neoplastic Cell Transformation 2 | 89
Neurodegenerative disease 2 | 414
Pancreatic carcinoma, familial 2 | 8
Pancreatitis 2 | 123
Papilloma 2 | 44
Pneumonia 2 | 174
Polycystic ovary syndrome 2 | 360
Pulmonary Fibrosis 2 | 106
Schizophrenia 2 | 1,160
Seizures 2 | 596
Skin cancer 2 | 469
Somatic mutation 2 | 61
Squamous cell carcinoma 2 | 129
Stomach cancer 2 | 30
Thrombocythemia, Essential 2 | 12
Thyroid cancer 2 | 36
Vascular disease 2 | 319
acute quadriplegic myopathy 2 | 1,158
astrocytic glioma 2 | 2,597
hearing impairment 2 | 199
mandibular excess (physical finding) 2 | 78
medulloblastoma 2 | 720
oligodendroglioma 2 | 2,850
posterior fossa group A ependymoma 2 | 468

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Transcription Factor 5 | 1,400
Non-IDG 1 | 12,091

Reactome Pathway

RUNX3 regulates CDKN1A transcr... 6 | 6
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Runt-related transcription factor 3 RUNX3 Tbio Transcription Factor -2.71721 536.2 438
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Mothers against decapentaplegic homolog 3 SMAD3 Tbio Transcription Factor -3.19667 1403.6 1526
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Zinc finger homeobox protein 3 ZFHX3 Tbio Transcription Factor -1.87242 83.8 71