Development Level

Tbio 22 | 11,445
Tchem 12 | 1,598
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal embryo size 3 | 220
preweaning lethality, incomple... 3 | 499
decreased vertical activity 2 | 208
edema 2 | 59
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal tibia morphology 1 | 14
anophthalmia 1 | 33
decreased NK T cell number 1 | 2
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87

Disease

ovarian cancer 28 | 8,520
Carcinoma 26 | 11,493
osteosarcoma 25 | 7,950
medulloblastoma, large-cell 19 | 6,241
glioblastoma 18 | 5,792
group 3 medulloblastoma 18 | 4,104
atypical teratoid / rhabdoid tumor 16 | 5,112
ependymoma 15 | 4,679
psoriasis 15 | 6,694
lung cancer 14 | 4,740
Cancer 12 | 2,499
Breast cancer 11 | 3,578
primitive neuroectodermal tumor 11 | 3,035
Kidney cancer 10 | 2,613
Rheumatoid arthritis 10 | 1,191
adult high grade glioma 10 | 3,801
oligodendroglioma 10 | 2,850
Intellectual disability 9 | 1,016
astrocytic glioma 9 | 2,597
Coffin-Siris syndrome 8 | 17
Small head 8 | 374
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Astrocytoma, Pilocytic 7 | 3,081
Epilepsy 7 | 792
Pick disease 7 | 1,894
Short stature 7 | 531
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
invasive ductal carcinoma 7 | 2,951
Acquired scoliosis 6 | 281
Cognitive delay 6 | 608
Cryptorchidism 6 | 296
Curvature of spine 6 | 282
Dull intelligence 6 | 645
Global developmental delay 6 | 608
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental and motor retardation 6 | 608
Mental deficiency 6 | 645
Poor school performance 6 | 645
Seizures 6 | 596
Waldenstrons macroglobulinemia 6 | 765
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
juvenile dermatomyositis 6 | 1,187
malignant mesothelioma 6 | 3,232
subependymal giant cell astrocytoma 6 | 2,287
Broad flat nasal bridge 5 | 236
Bushy eyebrows 5 | 49
Congenital deafness 5 | 185
Deafness 5 | 198
Feeding difficulties in infancy 5 | 175
Fetal Growth Retardation 5 | 189
Full lower lip 5 | 64
Hearing Loss, Partial 5 | 185
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Long eyelashes 5 | 37
Macrostomia 5 | 72
Muscle hypotonia 5 | 571
Nasal bridge wide 5 | 236
Prominent lower lip 5 | 64
Strabismus 5 | 270
dermatomyositis 5 | 966
group 4 medulloblastoma 5 | 1,855
hearing impairment 5 | 199
pancreatic cancer 5 | 2,398
pediatric high grade glioma 5 | 1,064
spina bifida 5 | 1,074
Abnormality of cardiovascular system morphology 4 | 23
Adenoid Cystic Carcinoma 4 | 99
Carcinoma, Adenoid Cystic 4 | 99
Carcinoma, Squamous Cell 4 | 110
Cerebellar hypoplasia and atrophy 4 | 41
Coarse facial features 4 | 108
Concave bridge of nose 4 | 195
Dandy-Walker Syndrome 4 | 39
Dental abnormalities 4 | 60
Depressed nasal bridge 4 | 195
Depressed nasal ridge 4 | 51
Depressed nasal root/bridge 4 | 195
Generalized hirsutism 4 | 36
Immune system cancer 4 | 140
Joint hyperflexibility 4 | 78
Large intestine cancer 4 | 126
Liver cancer 4 | 604
Multiple myeloma 4 | 1,332
Nystagmus 4 | 317
Patella aplasia-hypoplasia 4 | 12
Recurrent respiratory infections 4 | 141
Schizophrenia 4 | 1,160
Short distal phalanges 4 | 50
Squamous cell carcinoma 4 | 129
Thickened facial skin with coarse facial features 4 | 108
Tooth Abnormalities 4 | 69
acute quadriplegic myopathy 4 | 1,158
colon cancer 4 | 1,478
ductal carcinoma in situ 4 | 1,745
lung adenocarcinoma 4 | 2,716
pituitary cancer 4 | 1,972
progressive supranuclear palsy 4 | 676
tuberculosis 4 | 2,010

Tissue

Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Liver and Pancreas 36 | 16,750
Nervous System 36 | 16,725
Skin and soft tissues 36 | 17,230
Blood and immune system 35 | 16,909
Cardiovascular System 35 | 15,192
Female tissues 35 | 17,400
Male tissues 35 | 17,142
Respiratory system 35 | 16,393
Urinary Tract 35 | 16,678

Target Family

Non-IDG 13 | 12,091
Epigenetic 8 | 242
Transcription Factor 6 | 1,400
Kinase 4 | 634
TF/Epigenetic 3 | 38
Enzyme 2 | 4,145

Reactome Pathway

RUNX1 interacts with co-factor... 36 | 36
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chromobox protein homolog 8 CBX8 Tchem Epigenetic -2.27537 183.4 505
Protein polybromo-1 PBRM1 Tchem TF/Epigenetic -1.92500 84.6 97
Chromobox protein homolog 2 CBX2 Tchem Epigenetic -1.37369 24.3 223
Autism susceptibility gene 2 protein AUTS2 Tbio Non-IDG -1.62719 42.8 79
Actin-like protein 6B ACTL6B Tbio Non-IDG -0.88819 7.82 127
AT-rich interactive domain-containing protein 1B ARID1B Tbio Transcription Factor -1.88304 66.9 120
E3 SUMO-protein ligase CBX4 CBX4 Tchem Epigenetic -1.32793 21.9 353
Polyhomeotic-like protein 2 PHC2 Tbio Non-IDG -2.22805 167.4 82
AT-rich interactive domain-containing protein 1A ARID1A Tbio Transcription Factor -2.61778 423.3 132
SWI/SNF complex subunit SMARCC1 SMARCC1 Tbio TF/Epigenetic -1.82146 65.9 148