Development Level

Tbio 23 | 11,445
Tchem 6 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
abnormal behavior 2 | 298
decreased circulating amylase ... 2 | 28
decreased circulating bilirubi... 2 | 19
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal seminal vesicle morph... 1 | 114
brachydactyly 1 | 19
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased heart rate variabili... 1 | 7
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
persistence of hyaloid vascula... 1 | 33
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
stereotypic behavior 1 | 3
syndactyly 1 | 23
thrombocytosis 1 | 27
trunk curl 1 | 16

Disease

Carcinoma 18 | 11,493
ovarian cancer 16 | 8,520
glioblastoma 14 | 5,792
osteosarcoma 14 | 7,950
psoriasis 14 | 6,694
lung carcinoma 12 | 2,843
ependymoma 11 | 4,679
medulloblastoma, large-cell 11 | 6,241
astrocytic glioma 10 | 2,597
atypical teratoid / rhabdoid tumor 10 | 5,112
diabetes mellitus 9 | 1,728
oligodendroglioma 9 | 2,850
Astrocytoma, Pilocytic 8 | 3,081
adult high grade glioma 8 | 3,801
primitive neuroectodermal tumor 8 | 3,035
Autosomal recessive predisposition 7 | 1,442
Kidney disease 7 | 430
lung cancer 7 | 4,740
tuberculosis 7 | 2,010
Chronic Obstructive Airway Disease 6 | 37
Fever 6 | 138
Hypertension 6 | 396
Pick disease 6 | 1,894
group 3 medulloblastoma 6 | 4,104
invasive ductal carcinoma 6 | 2,951
Atherosclerosis 5 | 291
Chronic granulomatous disease 5 | 13
Diabetes Mellitus, Experimental 5 | 108
Hepatomegaly 5 | 285
Hypertensive disease 5 | 292
Liver Cirrhosis, Experimental 5 | 769
Multiple myeloma 5 | 1,332
Osteopetrosis 5 | 43
Otitis Media 5 | 52
Pyloric Stenosis 5 | 47
Recurrent respiratory infections 5 | 141
interstitial cystitis 5 | 2,312
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
subependymal giant cell astrocytoma 5 | 2,287
ulcerative colitis 5 | 1,819
Breast cancer 4 | 3,578
Hyperpigmented macules 4 | 42
Lymphadenopathy 4 | 62
Malabsorption 4 | 82
Mediastinal lymphadenopathy 4 | 10
Neutrophil abnormality 4 | 20
Paranasal Sinus Diseases 4 | 34
Photosensitivity of skin 4 | 51
Seizures 4 | 596
Sinusitis 4 | 65
Splenomegaly 4 | 190
Tracheoesophageal Fistula 4 | 36
group 4 medulloblastoma 4 | 1,855
periodontitis 4 | 293
Acute kidney injury 3 | 70
Alzheimer's disease 3 | 658
Arthritis, Rheumatoid 3 | 174
Brain Ischemia 3 | 110
Cerebrovascular disease 3 | 238
Coronary artery disease 3 | 268
Cutis Laxa 3 | 39
Depressive disorder 3 | 409
Diabetes Mellitus, Insulin-Dependent 3 | 48
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 1 3 | 43
Diabetes Mellitus, Type 2 3 | 142
Eczema 3 | 45
Escherichia coli Infections 3 | 4
Failure to gain weight 3 | 365
Granulomatosis 3 | 7
Heart failure 3 | 162
Infectious disease of lung 3 | 29
Kidney Failure, Chronic 3 | 46
Kidney cancer 3 | 2,613
Lupus Erythematosus, Discoid 3 | 4
Lymphadenitis 3 | 15
Mental Depression 3 | 333
Multiple pulmonary infections 3 | 29
Myocardial Reperfusion Injury 3 | 37
Osteomyelitis due to immunodeficiency 3 | 4
Pediatric failure to thrive 3 | 365
Perirectal abscess 3 | 5
Rectal abscess 3 | 5
Recurrent Staphylococcus aureus infections 3 | 4
Recurrent bacterial skin infections 3 | 8
Recurrent pneumonia 3 | 29
Recurrent pulmonary infections 3 | 29
Reperfusion Injury 3 | 86
Rheumatoid arthritis 3 | 1,191
Salmonellosis 3 | 42
chronic rhinosinusitis 3 | 512
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
mucosa-associated lymphoid tissue lymphoma 3 | 484
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972

Tissue

Blood and immune system 31 | 16,909
Male tissues 31 | 17,142
Urinary Tract 31 | 16,678
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Liver and Pancreas 29 | 16,750
Cardiovascular System 28 | 15,192

Target Family

Enzyme 25 | 4,145
Non-IDG 4 | 12,091
Ion Channel 1 | 344
Transporter 1 | 473

Reactome Pathway

ROS, RNS production in phagocy... 31 | 31
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 4 ATP6V0A4 Tbio Enzyme -2.84949 692.2 90
Cytochrome b-245 heavy chain CYBB Tchem Ion Channel -3.09698 1276.8 315
V-type proton ATPase subunit E 1 ATP6V1E1 Tbio Enzyme -1.04091 10.7 137
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.35134 2277.5 752
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.83801 66.4 144
Natural resistance-associated macrophage protein 1 SLC11A1 Tbio Transporter -2.77524 629.3 129
V-type proton ATPase subunit E 2 ATP6V1E2 Tbio Enzyme -0.78312 6.53 60
V-type proton ATPase subunit F ATP6V1F Tbio Enzyme -0.91914 8.76 118
V-type proton ATPase subunit C 1 ATP6V1C1 Tbio Enzyme -1.31659 21.7 102
V-type proton ATPase subunit B, brain isoform ATP6V1B2 Tchem Enzyme -1.39933 24.1 157