Development Level

Tbio 23 | 10,625
Tchem 5 | 1,890
Tdark 4 | 7,003

IMPC Term

embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 5 | 187
preweaning lethality, complete... 4 | 633
decreased mean corpuscular vol... 2 | 50
decreased total body fat amoun... 2 | 186
hypoactivity 2 | 89
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal seminal vesicle morph... 1 | 47
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean platelet volume 1 | 12
decreased prepulse inhibition 1 | 52
impaired righting response 1 | 19
increased bone mineral content 1 | 92
increased mean corpuscular hem... 1 | 93
increased spleen weight 1 | 3
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
small adrenal glands 1 | 15
small lymph nodes 1 | 1
stereotypic behavior 1 | 3
thrombocytosis 1 | 23
trunk curl 1 | 15

Disease

ovarian cancer 16 | 8,484
glioblastoma 15 | 5,572
osteosarcoma 15 | 7,933
psoriasis 14 | 6,685
lung carcinoma 13 | 2,844
medulloblastoma, large-cell 11 | 6,234
oligodendroglioma 10 | 2,849
atypical teratoid / rhabdoid tumor 9 | 4,369
diabetes mellitus 9 | 1,663
ependymoma 9 | 2,514
astrocytic glioma 8 | 2,241
pilocytic astrocytoma 8 | 3,086
primitive neuroectodermal tumor 8 | 3,031
Kidney disease 7 | 396
Pick disease 7 | 1,893
lung cancer 7 | 4,466
adult high grade glioma 6 | 2,148
invasive ductal carcinoma 6 | 2,950
pediatric high grade glioma 6 | 2,712
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 1,557
Atherosclerosis 5 | 275
Chronic granulomatous disease 5 | 13
Diabetes Mellitus, Experimental 5 | 106
Hypertension 5 | 287
Hypertensive disease 5 | 193
Multiple myeloma 5 | 1,327
Osteopetrosis 5 | 40
interstitial cystitis 5 | 2,299
medulloblastoma 5 | 1,524
non-small cell lung cancer 5 | 2,798
pancreatic cancer 5 | 2,300
ulcerative colitis 5 | 2,087
Breast cancer 4 | 3,094
astrocytoma 4 | 1,493
group 3 medulloblastoma 4 | 2,254
mucosa-associated lymphoid tissue lymphoma 4 | 480
periodontitis 4 | 269
tuberculosis and treatment for 6 months 4 | 686
Acute kidney injury 3 | 65
Alzheimer's disease 3 | 644
Brain Ischemia 3 | 87
Cerebrovascular disease 3 | 231
Cutis laxa 3 | 28
Diabetes Mellitus, Insulin-Dependent 3 | 76
Diabetes Mellitus, Non-Insulin-Dependent 3 | 157
Heart failure 3 | 80
IGA Glomerulonephritis 3 | 454
Kidney Failure, Chronic 3 | 45
Myocardial Reperfusion Injury 3 | 34
Reperfusion Injury 3 | 84
Rheumatoid Arthritis 3 | 1,160
atypical teratoid/rhabdoid tumor 3 | 1,095
chronic rhinosinusitis 3 | 512
cutaneous lupus erythematosus 3 | 1,056
cystic fibrosis 3 | 1,665
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 1,511
sonic hedgehog group medulloblastoma 3 | 1,482
Anoxia 2 | 33
Arthritis 2 | 248
Cancer 2 | 2,346
Coronary artery disease 2 | 240
Crohn Disease 2 | 97
Crohn's disease 2 | 304
Duchenne muscular dystrophy 2 | 602
Esophageal Neoplasms 2 | 67
Essential Hypertension 2 | 82
Gaucher disease type 1 2 | 171
Heart disease 2 | 279
Hyperalgesia 2 | 71
Impotence 2 | 45
Kidney Diseases 2 | 86
Leishmaniasis 2 | 49
Liver Cirrhosis, Experimental 2 | 108
Lung disease 2 | 132
Mammary Neoplasms 2 | 410
Multiple Sclerosis 2 | 498
Neurodegenerative disease 2 | 383
Parkinson's disease 2 | 364
Portal hypertension 2 | 21
Seizures 2 | 95
Sensorineural hearing loss 2 | 107
Status Epilepticus 2 | 85
Stomach Neoplasms 2 | 282
Toxic encephalopathy 2 | 131
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 918
acute myeloid leukemia 2 | 780
acute quadriplegic myopathy 2 | 1,157
adrenocortical carcinoma 2 | 1,427
breast carcinoma 2 | 1,614
dermatomyositis 2 | 933
hepatocellular carcinoma 2 | 532
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
lung adenocarcinoma 2 | 2,713
sarcoidosis 2 | 358

Tissue

Blood and immune system 32 | 17,995
Cardiovascular System 32 | 17,958
Digestive Tract 32 | 18,473
Male tissues 32 | 17,969
Nervous System 32 | 18,561
Skin and soft tissues 32 | 18,115
Urinary Tract 32 | 18,444
Endocrine System 31 | 18,512
Female tissues 31 | 18,647
Liver and Pancreas 31 | 18,136
Respiratory system 31 | 17,484

Target Family

Enzyme 26 | 4,146
Non-IDG 4 | 11,971
Ion Channel 1 | 341
Transporter 1 | 473

Reactome Pathway

ROS, RNS production in phagocy... 32 | 32
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56294 358.8 154
V-type proton ATPase 116 kDa subunit a isoform 1 ATP6V0A1 Tbio Enzyme -1.36455 23.7 59
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.32560 2206.3 649
V-type proton ATPase subunit e 2 ATP6V0E2 Tdark Enzyme 0.18 0.40 19
V-type proton ATPase subunit E 1 ATP6V1E1 Tbio Enzyme -0.98803 10.3 111
Cytochrome b-245 heavy chain CYBB Tchem Ion Channel -3.02894 1149.7 273
Natural resistance-associated macrophage protein 1 SLC11A1 Tbio Transporter -2.73579 594.1 110
Neutrophil cytosol factor 1 NCF1 Tbio Non-IDG -2.74083 539.0 597
V-type proton ATPase subunit B, kidney isoform ATP6V1B1 Tchem Enzyme -1.64875 40.5 209