Development Level

Tbio 49 | 10,625
Tdark 14 | 7,003
Tchem 7 | 1,890

IMPC Phenotype

preweaning lethality, complete... 9 | 633
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal foot plate morphology 1 | 2
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased CD103-positive CD11b... 1 | 2
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating amylase ... 1 | 24
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
enlarged epididymis 1 | 27
enlarged heart 1 | 111
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased circulating free fat... 1 | 17
increased circulating magnesiu... 1 | 10
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased mean corpuscular hem... 1 | 25
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
preweaning lethality, incomple... 1 | 260
vertebral transformation 1 | 12

Disease

ovarian cancer 41 | 8,491
osteosarcoma 30 | 7,933
psoriasis 19 | 6,685
lung cancer 18 | 4,473
malignant mesothelioma 16 | 3,163
glioblastoma 13 | 5,572
group 3 medulloblastoma 13 | 2,254
medulloblastoma, large-cell 13 | 6,234
atypical teratoid / rhabdoid tumor 11 | 4,369
Multiple myeloma 10 | 1,327
Breast cancer 9 | 3,098
oligodendroglioma 8 | 2,849
Pick disease 7 | 1,893
acute myeloid leukemia 7 | 785
acute quadriplegic myopathy 7 | 1,157
astrocytic glioma 7 | 2,241
ependymoma 7 | 2,514
hepatocellular carcinoma 7 | 550
non-small cell lung cancer 7 | 2,798
Cancer 6 | 2,346
astrocytoma 6 | 1,493
diabetes mellitus 6 | 1,663
pediatric high grade glioma 6 | 2,712
primitive neuroectodermal tumor 6 | 3,031
Carcinoma 5 | 2,147
Cockayne syndrome 5 | 54
cystic fibrosis 5 | 1,670
invasive ductal carcinoma 5 | 2,950
medulloblastoma 5 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
pituitary cancer 5 | 1,972
Photosensitive trichothiodystrophy 4 | 24
breast carcinoma 4 | 1,614
dermatomyositis 4 | 966
non primary Sjogren syndrome sicca 4 | 840
pancreatic cancer 4 | 2,300
primary pancreatic ductal adenocarcinoma 4 | 1,271
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 2,087
group 4 medulloblastoma 3 | 1,875
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
juvenile dermatomyositis 3 | 1,189
lung adenocarcinoma 3 | 2,714
pancreatic carcinoma 3 | 567
posterior fossa group A ependymoma 3 | 1,511
sonic hedgehog group medulloblastoma 3 | 1,482
tuberculosis and treatment for 3 months 3 | 327
tuberculosis and treatment for 6 months 3 | 686
Acquired immunodeficiency syndrome 2 | 164
Epidermodysplasia verruciformis 2 | 21
IGA Glomerulonephritis 2 | 454
Mixed connective tissue disease 2 | 16
Peripheral Neuropathy 2 | 303
Waldenstrons macroglobulinemia 2 | 764
active Crohn's disease 2 | 918
ductal carcinoma in situ 2 | 1,745
gastric cancer 2 | 436
inflammatory breast cancer 2 | 404
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
lung carcinoma 2 | 2,844
nasopharyngeal carcinoma 2 | 1,056
pilocytic astrocytoma 2 | 3,086
primary Sjogren syndrome 2 | 788
tuberculosis 2 | 1,563
Ankylosing spondylitis 1 | 138
Autosomal dominant cerebellar ataxia 1 | 34
Bipolar Disorder 1 | 266
Cardiovascular system disease 1 | 194
Cerebellar Ataxia 1 | 72
Choreatic disease 1 | 27
Cocaine-Related Disorders 1 | 88
Dementia 1 | 129
Dystonia 1 | 77
Eumycotic mycetoma 1 | 3
Fusariosis 1 | 6
Gaucher disease type 1 1 | 171
Gaucher disease type 3 1 | 76
HIV Infections 1 | 99
Huntington's disease 1 | 72
Lymphoma 1 | 57
Machado-Joseph disease 1 | 18
Malignant neoplasm of breast 1 | 63
Megaloblastic anemia 1 | 18
Muscular atrophy 1 | 67
Neoplasm Metastasis 1 | 138
Neurodegenerative disease 1 | 383
Osteoporosis 1 | 259
Poland syndrome 1 | 7
Subcutaneous mycosis 1 | 1
Thalassemia 1 | 46
Tinea pedis 1 | 30
Vaccinia 1 | 37
Vasculitis 1 | 64
active ulcerative colitis 1 | 477
dentatorubral-pallidoluysian atrophy 1 | 21
hereditary spastic paraplegia 1 | 313
interstitial lung disease 1 | 292
sarcoidosis 1 | 368
type II diabetes mellitus and post-ischemic heart failure 1 | 89

Tissue

Blood and immune system 70 | 17,994
Cardiovascular System 70 | 17,957
Digestive Tract 70 | 18,472
Endocrine System 70 | 18,511
Female tissues 70 | 18,646
Liver and Pancreas 70 | 18,135
Male tissues 70 | 17,968
Nervous System 70 | 18,560
Respiratory system 69 | 17,483
Skin and soft tissues 69 | 18,114
Urinary Tract 69 | 18,443

Target Family

Non-IDG 46 | 11,969
Enzyme 16 | 4,146
Transcription Factor 5 | 1,400
Kinase 2 | 634
Epigenetic 1 | 242

Reactome Pathway

RNA polymerase II transcribes ... 70 | 70
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
Transcription initiation factor IIA subunit 2 GTF2A2 Tbio Non-IDG -1.17322 15.5 31
Transcription initiation factor IIA subunit 1 GTF2A1 Tchem Non-IDG -0.11090 0.73 228
Nuclear cap-binding protein subunit 1 NCBP1 Tbio Non-IDG -2.31776 194.4 161
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.14104 13.5 159
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.42612 28.8 182
Zinc finger protein 143 ZNF143 Tbio Transcription Factor -2.46665 293.8 52
Integrator complex subunit 11 CPSF3L Tbio Non-IDG -0.79472 5.46 101
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.89072 7.36 47
von Willebrand factor A domain-containing protein 9 VWA9 Tdark Non-IDG 0.85 0.14 55