Development Level

Tbio 58 | 11,651
Tdark 9 | 6,593
Tchem 4 | 1,388

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 6 | 278
abnormal embryo size 3 | 220
abnormal heart morphology 2 | 162
increased circulating potassiu... 2 | 29
abnormal chorioallantoic fusio... 1 | 8
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal humerus morphology 1 | 11
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
female infertility 1 | 60
hydrometra 1 | 53
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating magnesiu... 1 | 10
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74

Disease

Carcinoma 43 | 11,493
ovarian cancer 43 | 8,520
osteosarcoma 32 | 7,950
lung cancer 19 | 4,740
psoriasis 19 | 6,694
group 3 medulloblastoma 16 | 4,104
malignant mesothelioma 16 | 3,232
Breast cancer 12 | 3,578
Kidney cancer 12 | 2,613
medulloblastoma, large-cell 12 | 6,241
ependymoma 11 | 4,679
glioblastoma 11 | 5,792
Multiple myeloma 10 | 1,332
atypical teratoid / rhabdoid tumor 10 | 5,112
Pick disease 7 | 1,894
acute myeloid leukemia 7 | 783
acute quadriplegic myopathy 7 | 1,158
diabetes mellitus 7 | 1,728
hepatocellular carcinoma 7 | 547
oligodendroglioma 7 | 2,850
Cancer 6 | 2,499
Cockayne syndrome 6 | 60
astrocytic glioma 6 | 2,597
astrocytoma 6 | 1,146
group 4 medulloblastoma 6 | 1,855
non-small cell lung cancer 6 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,035
adult high grade glioma 5 | 3,801
cystic fibrosis 5 | 1,696
invasive ductal carcinoma 5 | 2,951
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Hereditary spherocytosis type 5 4 | 12
Photosensitive trichothiodystrophy 4 | 30
Xeroderma pigmentosum group B 4 | 20
breast carcinoma 4 | 1,638
non primary Sjogren syndrome sicca 4 | 891
pancreatic cancer 4 | 2,398
primary pancreatic ductal adenocarcinoma 4 | 1,109
subependymal giant cell astrocytoma 4 | 2,287
dermatomyositis 3 | 966
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
pancreatic carcinoma 3 | 562
tuberculosis and treatment for 3 months 3 | 179
Acquired immunodeficiency syndrome 2 | 197
Astrocytoma, Pilocytic 2 | 3,081
Bipolar Disorder 2 | 666
Congenital myasthenic syndrome 5 2 | 11
Epidermodysplasia verruciformis 2 | 21
Intellectual disability 2 | 1,016
Mixed connective tissue disease 2 | 16
Paranoia 2 | 20
Periventricular nodular heterotopia 2 | 30
Schizophrenia 2 | 1,160
Waldenstrons macroglobulinemia 2 | 765
Wolf-Hirschhorn syndrome 2 | 32
active Crohn's disease 2 | 922
ductal carcinoma in situ 2 | 1,745
gastric cancer 2 | 459
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung carcinoma 2 | 2,843
pediatric high grade glioma 2 | 1,064
primary Sjogren syndrome 2 | 735
Acute Promyelocytic Leukemia 1 | 40
Alagille syndrome 1 | 15
Ankylosing spondylitis 1 | 140
Autosomal dominant cerebellar ataxia 1 | 33
Brain disease 1 | 96
Broad-based gait 1 | 19
COPD 1 | 118
Chronic schizophrenia 1 | 16
Deglutition Disorders 1 | 132
Diffuse cerebral atrophy 1 | 8
Facioscapulohumeral muscular dystrophy 1 | 26
Gaucher disease type 3 1 | 67
HIV Infections 1 | 102
Hallucinations 1 | 34
Hallucinations, Sensory 1 | 33
Hereditary spherocytosis type 2 1 | 18
Lymphoid leukemia 1 | 160
Muscle Rigidity 1 | 49
Muscular atrophy 1 | 71
Myoclonus 1 | 74
Nonorganic psychosis 1 | 84
PARKINSON DISEASE, LATE-ONSET 1 | 20
Panic disorder 1 | 61
Parkinsonian Disorders 1 | 56
Prader-Willi syndrome 1 | 48
Roberts syndrome 1 | 15
Romberg's sign positive 1 | 4
Specific language impairment 1 | 34
Thalassemia 1 | 53
chorea-acanthocytosis 1 | 12
interstitial lung disease 1 | 298
sarcoidosis 1 | 370

Tissue

Blood and immune system 71 | 16,909
Cardiovascular System 71 | 15,192
Digestive Tract 71 | 17,369
Endocrine System 71 | 18,159
Female tissues 71 | 17,400
Liver and Pancreas 71 | 16,750
Male tissues 71 | 17,142
Nervous System 71 | 16,725
Respiratory system 71 | 16,393
Skin and soft tissues 71 | 17,230
Urinary Tract 71 | 16,678

Target Family

Non-IDG 46 | 12,091
Enzyme 17 | 4,145
Transcription Factor 5 | 1,400
Kinase 2 | 634
Epigenetic 1 | 242

Reactome Pathway

RNA polymerase II transcribes ... 71 | 71
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
snRNA-activating protein complex subunit 4 SNAPC4 Tbio Transcription Factor -0.99715 10.0 160
Integrator complex subunit 6 INTS6 Tbio Non-IDG -2.07240 118.9 80
Transcription initiation factor IIB GTF2B Tbio Non-IDG -2.63302 410.1 286
Nuclear cap-binding protein subunit 2 NCBP2 Tbio Non-IDG -1.45099 24.2 110
Integrator complex subunit 10 INTS10 Tdark Non-IDG -0.67290 3.96 116
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.43224 29.3 213
Nuclear cap-binding protein subunit 1 NCBP1 Tbio Non-IDG -2.34134 207.7 172
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.77350 60.4 174
Zinc finger protein 143 ZNF143 Tbio Transcription Factor -2.48767 308.2 62
Transcription elongation factor SPT4 SUPT4H1 Tbio Non-IDG -1.65513 43.4 92