Development Level

Tbio 49 | 10,625
Tdark 14 | 7,003
Tchem 7 | 1,890

IMPC Term

preweaning lethality, complete... 9 | 633
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal foot plate morphology 1 | 2
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased CD103-positive CD11b... 1 | 2
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating amylase ... 1 | 24
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
enlarged epididymis 1 | 27
enlarged heart 1 | 111
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased circulating free fat... 1 | 17
increased circulating magnesiu... 1 | 10
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased mean corpuscular hem... 1 | 25
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
preweaning lethality, incomple... 1 | 260
vertebral transformation 1 | 12

Disease

ovarian cancer 41 | 8,484
osteosarcoma 30 | 7,933
psoriasis 19 | 6,685
lung cancer 18 | 4,466
malignant mesothelioma 16 | 3,162
glioblastoma 13 | 5,572
group 3 medulloblastoma 13 | 2,254
medulloblastoma, large-cell 13 | 6,234
atypical teratoid / rhabdoid tumor 11 | 4,369
Multiple myeloma 10 | 1,327
Breast cancer 9 | 3,094
oligodendroglioma 8 | 2,849
Pick disease 7 | 1,893
acute myeloid leukemia 7 | 780
acute quadriplegic myopathy 7 | 1,157
astrocytic glioma 7 | 2,241
ependymoma 7 | 2,514
hepatocellular carcinoma 7 | 532
non-small cell lung cancer 7 | 2,798
Cancer 6 | 2,346
astrocytoma 6 | 1,493
diabetes mellitus 6 | 1,663
pediatric high grade glioma 6 | 2,712
primitive neuroectodermal tumor 6 | 3,031
Carcinoma 5 | 2,147
Cockayne syndrome 5 | 54
cystic fibrosis 5 | 1,665
invasive ductal carcinoma 5 | 2,950
medulloblastoma 5 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
pituitary cancer 5 | 1,972
Photosensitive trichothiodystrophy 4 | 24
breast carcinoma 4 | 1,614
dermatomyositis 4 | 933
non primary Sjogren syndrome sicca 4 | 840
pancreatic cancer 4 | 2,300
primary pancreatic ductal adenocarcinoma 4 | 1,271
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 2,087
group 4 medulloblastoma 3 | 1,875
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
juvenile dermatomyositis 3 | 1,189
lung adenocarcinoma 3 | 2,713
pancreatic carcinoma 3 | 567
posterior fossa group A ependymoma 3 | 1,511
sonic hedgehog group medulloblastoma 3 | 1,482
tuberculosis and treatment for 3 months 3 | 327
tuberculosis and treatment for 6 months 3 | 686
Acquired immunodeficiency syndrome 2 | 164
Epidermodysplasia verruciformis 2 | 21
IGA Glomerulonephritis 2 | 454
Mixed connective tissue disease 2 | 16
Peripheral Neuropathy 2 | 303
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 918
ductal carcinoma in situ 2 | 1,745
gastric cancer 2 | 430
inflammatory breast cancer 2 | 404
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
lung carcinoma 2 | 2,844
nasopharyngeal carcinoma 2 | 1,056
pilocytic astrocytoma 2 | 3,086
primary Sjogren syndrome 2 | 789
tuberculosis 2 | 1,557
Ankylosing spondylitis 1 | 138
Atrial Fibrillation 1 | 110
Bipolar Disorder 1 | 266
Cardiovascular system disease 1 | 194
Choreatic disease 1 | 27
Chronic obstructive pulmonary disease 1 | 146
Cocaine-Related Disorders 1 | 88
Dementia 1 | 129
Dystonia 1 | 77
Eumycotic mycetoma 1 | 3
Fusariosis 1 | 6
Gaucher disease type 1 1 | 171
Gaucher disease type 3 1 | 76
HIV Infections 1 | 100
Huntington's disease 1 | 72
Leukemia 1 | 88
Lymphoma 1 | 56
Machado-Joseph disease 1 | 18
Malignant neoplasm of breast 1 | 63
Megaloblastic anemia 1 | 16
Muscular atrophy 1 | 67
Neoplasm Metastasis 1 | 138
Neurodegenerative disease 1 | 383
Osteoporosis 1 | 257
Poland syndrome 1 | 7
Subcutaneous mycosis 1 | 1
Thalassemia 1 | 46
Tinea pedis 1 | 30
Vasculitis 1 | 64
active ulcerative colitis 1 | 477
dentatorubral-pallidoluysian atrophy 1 | 21
hereditary spastic paraplegia 1 | 313
interstitial lung disease 1 | 291
sarcoidosis 1 | 358
type II diabetes mellitus and post-ischemic heart failure 1 | 89

Tissue

Blood and immune system 70 | 17,995
Cardiovascular System 70 | 17,958
Digestive Tract 70 | 18,473
Endocrine System 70 | 18,512
Female tissues 70 | 18,647
Liver and Pancreas 70 | 18,136
Male tissues 70 | 17,969
Nervous System 70 | 18,561
Respiratory system 69 | 17,484
Skin and soft tissues 69 | 18,115
Urinary Tract 69 | 18,444

Target Family

Non-IDG 46 | 11,971
Enzyme 16 | 4,146
Transcription Factor 5 | 1,400
Kinase 2 | 634
Epigenetic 1 | 242

Reactome Pathway

RNA polymerase II transcribes ... 70 | 70
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.74939 59.4 153
General transcription factor IIF subunit 2 GTF2F2 Tbio Non-IDG -1.54703 35.9 153
Integrator complex subunit 5 INTS5 Tdark Non-IDG -1.17506 15.4 45
POU domain, class 2, transcription factor 2 POU2F2 Tchem Transcription Factor -1.45774 28.7 332
Cyclin-dependent kinase 7 CDK7 Tchem Kinase -2.28652 191.1 505
Transcription initiation factor TFIID subunit 6 TAF6 Tbio Non-IDG -1.10513 12.5 129
DNA-directed RNA polymerase II subunit RPB4 POLR2D Tdark Enzyme -0.50937 3.13 114
General transcription factor IIF subunit 1 GTF2F1 Tbio Non-IDG -1.59692 42.8 148
Integrator complex subunit 2 INTS2 Tdark Non-IDG -0.02119 1.05 38
DNA-directed RNA polymerases I, II, and III subunit RPABC5 POLR2L Tbio Enzyme -0.98287 10.2 60