Development Level

Tbio 42 | 10,625
Tchem 3 | 1,890
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 6 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 3 | 187
abnormal retina morphology 2 | 100
decreased CD103-positive CD11b... 1 | 2
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating sodium l... 1 | 18
hypoactivity 1 | 89
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased exploration in new e... 1 | 56
vertebral transformation 1 | 12

Disease

ovarian cancer 25 | 8,484
osteosarcoma 21 | 7,933
lung cancer 16 | 4,466
Photosensitive trichothiodystrophy 10 | 24
Cockayne syndrome 9 | 54
Multiple myeloma 8 | 1,327
psoriasis 8 | 6,685
Cancer 6 | 2,346
Xeroderma pigmentosum 6 | 41
glioblastoma 6 | 5,572
Carcinoma 5 | 2,147
Epidermodysplasia verruciformis 5 | 21
Pick disease 5 | 1,893
acute myeloid leukemia 5 | 780
diabetes mellitus 5 | 1,663
group 3 medulloblastoma 5 | 2,254
malignant mesothelioma 5 | 3,162
medulloblastoma, large-cell 5 | 6,234
Breast cancer 4 | 3,094
Peripheral Neuropathy 4 | 303
ependymoma 4 | 2,514
oligodendroglioma 4 | 2,849
primitive neuroectodermal tumor 4 | 3,031
Intellectual disability 3 | 573
Trichothiodystrophy Syndromes 3 | 5
Waldenstrons macroglobulinemia 3 | 765
adult high grade glioma 3 | 2,148
astrocytic glioma 3 | 2,241
atypical teratoid / rhabdoid tumor 3 | 4,369
hepatocellular carcinoma 3 | 532
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
medulloblastoma 3 | 1,524
pediatric high grade glioma 3 | 2,712
pilocytic astrocytoma 3 | 3,086
pituitary cancer 3 | 1,972
subependymal giant cell astrocytoma 3 | 2,287
Baller-Gerold syndrome 2 | 14
Dystonia 2 | 77
Infertility 2 | 163
Mixed connective tissue disease 2 | 16
Rheumatoid Arthritis 2 | 1,160
Rothmund-Thomson syndrome 2 | 22
Spinocerebellar ataxia type 7 2 | 13
Werner syndrome 2 | 29
acute quadriplegic myopathy 2 | 1,157
astrocytoma 2 | 1,493
breast carcinoma 2 | 1,614
cystic fibrosis 2 | 1,665
dermatomyositis 2 | 933
group 4 medulloblastoma 2 | 1,875
invasive ductal carcinoma 2 | 2,950
juvenile dermatomyositis 2 | 1,189
lung adenocarcinoma 2 | 2,713
lung carcinoma 2 | 2,844
nasopharyngeal carcinoma 2 | 1,056
pancreatic cancer 2 | 2,300
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
tuberculosis 2 | 1,557
Acquired metabolic disease 1 | 267
Animal Mammary Neoplasms 1 | 136
Arsenic Poisoning 1 | 59
Autosomal dominant cerebellar ataxia 1 | 34
Bladder Neoplasm 1 | 109
Cataract 1 | 104
Cerebellar Ataxia 1 | 72
Choreatic disease 1 | 27
Colorectal Neoplasms 1 | 217
Dementia 1 | 129
Dermatologic disorders 1 | 65
Disseminated intravascular coagulation 1 | 32
Eumycotic mycetoma 1 | 3
Fusariosis 1 | 6
Gaucher disease type 1 1 | 171
HIV Infections 1 | 100
Hereditary spherocytosis 1 | 20
Huntington's disease 1 | 72
IGA Glomerulonephritis 1 | 454
Machado-Joseph disease 1 | 18
Male infertility 1 | 170
Mammary Neoplasms, Experimental 1 | 150
Maple syrup urine disease 1 | 25
Megaloblastic anemia 1 | 16
Mental depression 1 | 58
Microcephaly 1 | 149
Muscular atrophy 1 | 67
Neurodegenerative disease 1 | 383
Orchitis 1 | 16
Parkinson's disease 1 | 364
Polycystic Ovary Syndrome 1 | 332
Squamous cell carcinoma 1 | 94
Stomach Neoplasms 1 | 282
Subcutaneous mycosis 1 | 1
Tinea pedis 1 | 30
Venous Thromboembolism 1 | 34
active Crohn's disease 1 | 918
active ulcerative colitis 1 | 477
atypical teratoid/rhabdoid tumor 1 | 1,095
dentatorubral-pallidoluysian atrophy 1 | 21
tuberculosis and treatment for 6 months 1 | 686

Tissue

Blood and immune system 46 | 17,995
Cardiovascular System 46 | 17,958
Digestive Tract 46 | 18,473
Endocrine System 46 | 18,512
Female tissues 46 | 18,647
Liver and Pancreas 46 | 18,136
Male tissues 46 | 17,969
Nervous System 46 | 18,561
Respiratory system 45 | 17,484
Skin and soft tissues 45 | 18,115
Urinary Tract 45 | 18,444

Target Family

Non-IDG 27 | 11,971
Enzyme 15 | 4,146
Epigenetic 2 | 242
Kinase 2 | 634

Reactome Pathway

RNA Polymerase II Transcriptio... 46 | 46
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.74939 59.4 153
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.79392 6.02 65
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -0.87357 6.84 120
General transcription factor IIF subunit 2 GTF2F2 Tbio Non-IDG -1.54703 35.9 153
Cyclin-dependent kinase 7 CDK7 Tchem Kinase -2.28652 191.1 505
Cyclin-H CCNH Tbio Non-IDG -1.98840 89.8 354
CDK-activating kinase assembly factor MAT1 MNAT1 Tbio Enzyme -2.07687 125.7 152
Transcription initiation factor TFIID subunit 1-like TAF1L Tchem Epigenetic -0.01848 2.40 39
Transcription initiation factor TFIID subunit 6 TAF6 Tbio Non-IDG -1.10513 12.5 129
DNA-directed RNA polymerase II subunit RPB4 POLR2D Tdark Enzyme -0.50937 3.13 114