Development Level

Tbio 42 | 10,625
Tchem 3 | 1,890
Tdark 1 | 7,003

IMPC Phenotype

preweaning lethality, complete... 6 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 3 | 187
abnormal retina morphology 2 | 100
decreased CD103-positive CD11b... 1 | 2
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating sodium l... 1 | 18
hypoactivity 1 | 89
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased exploration in new e... 1 | 56
vertebral transformation 1 | 12

Disease

ovarian cancer 25 | 8,491
osteosarcoma 21 | 7,933
lung cancer 16 | 4,473
Photosensitive trichothiodystrophy 10 | 24
Cockayne syndrome 9 | 54
Multiple myeloma 8 | 1,327
psoriasis 8 | 6,685
Cancer 6 | 2,346
Xeroderma pigmentosum 6 | 41
glioblastoma 6 | 5,572
Carcinoma 5 | 2,147
Epidermodysplasia verruciformis 5 | 21
Pick disease 5 | 1,893
acute myeloid leukemia 5 | 785
diabetes mellitus 5 | 1,663
group 3 medulloblastoma 5 | 2,254
malignant mesothelioma 5 | 3,163
medulloblastoma, large-cell 5 | 6,234
Breast cancer 4 | 3,098
Peripheral Neuropathy 4 | 303
ependymoma 4 | 2,514
oligodendroglioma 4 | 2,849
primitive neuroectodermal tumor 4 | 3,031
Intellectual disability 3 | 573
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 5
Waldenstrons macroglobulinemia 3 | 764
adult high grade glioma 3 | 2,148
astrocytic glioma 3 | 2,241
atypical teratoid / rhabdoid tumor 3 | 4,369
hepatocellular carcinoma 3 | 550
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
medulloblastoma 3 | 1,524
pediatric high grade glioma 3 | 2,712
pilocytic astrocytoma 3 | 3,086
pituitary cancer 3 | 1,972
subependymal giant cell astrocytoma 3 | 2,287
Baller-Gerold syndrome 2 | 14
Dystonia 2 | 77
Infertility 2 | 163
Mixed connective tissue disease 2 | 16
Rheumatoid Arthritis 2 | 1,170
Rothmund-Thomson syndrome 2 | 22
Spinocerebellar ataxia type 7 2 | 13
Werner syndrome 2 | 29
Xeroderma pigmentosum-Cockayne syndrome complex 2 | 4
acute quadriplegic myopathy 2 | 1,157
astrocytoma 2 | 1,493
breast carcinoma 2 | 1,614
cystic fibrosis 2 | 1,670
dermatomyositis 2 | 966
group 4 medulloblastoma 2 | 1,875
invasive ductal carcinoma 2 | 2,950
juvenile dermatomyositis 2 | 1,189
lung adenocarcinoma 2 | 2,714
lung carcinoma 2 | 2,844
nasopharyngeal carcinoma 2 | 1,056
pancreatic cancer 2 | 2,300
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
tuberculosis 2 | 1,563
Acquired metabolic disease 1 | 267
Animal Mammary Neoplasms 1 | 135
Arsenic Poisoning 1 | 59
Autosomal dominant cerebellar ataxia 1 | 34
Bladder Neoplasm 1 | 109
Cataract 1 | 104
Cerebellar Ataxia 1 | 72
Chikungunya 1 | 12
Choreatic disease 1 | 27
Choroid Plexus Carcinoma 1 | 4
Colorectal Neoplasms 1 | 217
Dementia 1 | 129
Dermatologic disorders 1 | 65
Disseminated intravascular coagulation 1 | 32
Ewing sarcoma 1 | 27
Gaucher disease type 1 1 | 171
HIV Infections 1 | 99
Hereditary spherocytosis 1 | 20
La Crosse encephalitis 1 | 6
Machado-Joseph disease 1 | 18
Male infertility with azoospermia or oligozoospermia due to single gene mutation 1 | 9
Malignant neoplasm of lung 1 | 16
Mammary Neoplasms, Experimental 1 | 149
Microcephaly 1 | 149
Muscular atrophy 1 | 67
Orchitis 1 | 16
PARKINSON DISEASE, LATE-ONSET 1 | 20
Rift Valley fever 1 | 13
Skin Neoplasms 1 | 49
Skin benign neoplasm 1 | 5
Spinocerebellar ataxia type 17 1 | 7
Spinocerebellar ataxia type 2 1 | 19
Squamous cell carcinoma 1 | 96
Sunburn 1 | 3
Vaccinia 1 | 37
Venous Thromboembolism 1 | 34
active ulcerative colitis 1 | 477
chorea-acanthocytosis 1 | 11
dentatorubral-pallidoluysian atrophy 1 | 21

Tissue

Blood and immune system 46 | 17,994
Cardiovascular System 46 | 17,957
Digestive Tract 46 | 18,472
Endocrine System 46 | 18,511
Female tissues 46 | 18,646
Liver and Pancreas 46 | 18,135
Male tissues 46 | 17,968
Nervous System 46 | 18,560
Respiratory system 45 | 17,483
Skin and soft tissues 45 | 18,114
Urinary Tract 45 | 18,443

Target Family

Non-IDG 27 | 11,969
Enzyme 15 | 4,146
Epigenetic 2 | 242
Kinase 2 | 634

Reactome Pathway

RNA Polymerase II Transcriptio... 46 | 46
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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