Development Level

Tbio 58 | 11,445
Tdark 11 | 6,588
Tchem 6 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
abnormal bone mineralization 1 | 38
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal posture 1 | 2
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating sodium l... 1 | 22
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lumbar vertebrae num... 1 | 2
decreased sacral vertebrae num... 1 | 1
hemorrhage 1 | 23
hypoactivity 1 | 132
increased anti-nuclear antigen... 1 | 19
increased body temperature 1 | 9
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased lumbar vertebrae num... 1 | 1
increased sacral vertebrae num... 1 | 1
increased total body fat amoun... 1 | 134
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

ovarian cancer 40 | 8,520
Carcinoma 39 | 11,493
lung cancer 32 | 4,740
osteosarcoma 27 | 7,950
psoriasis 24 | 6,694
Cancer 19 | 2,499
glioblastoma 18 | 5,792
group 3 medulloblastoma 17 | 4,104
Breast cancer 16 | 3,578
lung adenocarcinoma 16 | 2,716
medulloblastoma, large-cell 15 | 6,241
Multiple myeloma 14 | 1,332
atypical teratoid / rhabdoid tumor 14 | 5,112
Cockayne syndrome 11 | 60
Photosensitive trichothiodystrophy 11 | 30
ependymoma 11 | 4,679
invasive ductal carcinoma 11 | 2,951
non-small cell lung cancer 11 | 2,890
primitive neuroectodermal tumor 11 | 3,035
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
breast carcinoma 9 | 1,638
group 4 medulloblastoma 9 | 1,855
malignant mesothelioma 9 | 3,232
Intellectual disability 8 | 1,016
Schizophrenia 8 | 1,160
pancreatic cancer 8 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Kidney cancer 7 | 2,613
colon cancer 7 | 1,478
diabetes mellitus 7 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pediatric high grade glioma 7 | 1,064
subependymal giant cell astrocytoma 7 | 2,287
Astrocytoma, Pilocytic 6 | 3,081
Cleft Palate 6 | 271
Endometriosis 6 | 540
Pick disease 6 | 1,894
Waldenstrons macroglobulinemia 6 | 765
Xeroderma pigmentosum 6 | 43
Xeroderma pigmentosum group B 6 | 20
acute myeloid leukemia 6 | 783
adult high grade glioma 6 | 3,801
astrocytoma 6 | 1,146
nasopharyngeal carcinoma 6 | 1,058
spina bifida 6 | 1,074
Hypoplastic mandible condyle 5 | 275
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Rheumatoid arthritis 5 | 1,191
Strabismus 5 | 270
Xeroderma pigmentosum group D 5 | 33
acute quadriplegic myopathy 5 | 1,158
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
oligodendroglioma 5 | 2,850
Autosomal recessive predisposition 4 | 1,442
Broad flat nasal bridge 4 | 236
Carcinoma, Squamous Cell 4 | 110
Cataract 4 | 297
Cerebellar Ataxia 4 | 304
Dull intelligence 4 | 645
Low Vision 4 | 174
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Nasal bridge wide 4 | 236
Poor school performance 4 | 645
Small head 4 | 374
Squamous cell carcinoma 4 | 129
Treacher Collins syndrome 4 | 27
Visual Impairment 4 | 174
Xeroderma pigmentosum group G 4 | 16
astrocytic glioma 4 | 2,597
cutaneous lupus erythematosus 4 | 1,057
gastric cancer 4 | 459
non-small cell lung carcinoma 4 | 317
pancreatic carcinoma 4 | 562
pituitary cancer 4 | 1,972
posterior fossa group A ependymoma 4 | 468
Cerebellar degeneration 3 | 103
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Gliosis 3 | 56
Lung Neoplasms 3 | 232
Melanoma 3 | 711
Mental Depression 3 | 333
Mood Disorders 3 | 184
Muscle Spasticity 3 | 195
Pediatric failure to thrive 3 | 365
Prostatic Neoplasms 3 | 495
Seizures 3 | 596
Stomach Neoplasms 3 | 300
gastric carcinoma 3 | 807
hepatocellular carcinoma 3 | 547
juvenile dermatomyositis 3 | 1,187
primary pancreatic ductal adenocarcinoma 3 | 1,109
sonic hedgehog group medulloblastoma 3 | 467
tuberculosis 3 | 2,010

Tissue

Endocrine System 75 | 18,159
Blood and immune system 74 | 16,909
Digestive Tract 74 | 17,369
Female tissues 74 | 17,400
Skin and soft tissues 74 | 17,230
Cardiovascular System 73 | 15,192
Liver and Pancreas 73 | 16,750
Male tissues 73 | 17,142
Nervous System 73 | 16,725
Respiratory system 73 | 16,393
Urinary Tract 73 | 16,678

Target Family

Non-IDG 38 | 12,091
Enzyme 21 | 4,145
Epigenetic 8 | 242
Transcription Factor 8 | 1,400
Kinase 2 | 634

Reactome Pathway

RNA Polymerase I Transcription 77 | 77
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Metastasis-associated protein MTA2 MTA2 Tbio Transcription Factor -1.59201 32.3 283
Chromodomain-helicase-DNA-binding protein 4 CHD4 Tbio Epigenetic -2.22229 159.7 203
Histone H2A.J H2AFJ Tdark Non-IDG -0.00172 0.83 99
Methyl-CpG-binding domain protein 3 MBD3 Tbio Transcription Factor -0.85800 7.92 309
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 16
Chromodomain-helicase-DNA-binding protein 3 CHD3 Tbio Epigenetic -1.95633 85.2 190