Development Level

Tbio 39 | 10,625
Tdark 14 | 7,003
Tchem 2 | 1,890

IMPC Term

embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal retina morphology 1 | 100
decreased body weight 1 | 174
decreased circulating sodium l... 1 | 18
decreased lumbar vertebrae num... 1 | 62
decreased rib number 1 | 59
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased sacral vertebrae num... 1 | 62

Disease

ovarian cancer 28 | 8,492
lung cancer 22 | 4,473
psoriasis 18 | 6,685
osteosarcoma 16 | 7,933
Breast cancer 13 | 3,099
Multiple myeloma 12 | 1,328
lung adenocarcinoma 12 | 2,714
Cancer 11 | 2,346
glioblastoma 11 | 5,572
invasive ductal carcinoma 10 | 2,950
breast carcinoma 9 | 1,614
ductal carcinoma in situ 9 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
medulloblastoma, large-cell 8 | 6,234
non-small cell lung cancer 8 | 2,798
pancreatic cancer 8 | 2,300
Photosensitive trichothiodystrophy 7 | 24
malignant mesothelioma 7 | 3,163
pediatric high grade glioma 7 | 2,712
Cockayne syndrome 6 | 54
Xeroderma pigmentosum 6 | 41
atypical teratoid / rhabdoid tumor 6 | 4,369
colon cancer 6 | 1,475
group 3 medulloblastoma 6 | 2,254
group 4 medulloblastoma 6 | 1,875
nasopharyngeal carcinoma 6 | 1,056
Pick disease 5 | 1,893
acute myeloid leukemia 5 | 785
atypical teratoid/rhabdoid tumor 5 | 1,095
cystic fibrosis 5 | 1,670
diabetes mellitus 5 | 1,663
ependymoma 5 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
non-small cell lung carcinoma 5 | 413
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
primitive neuroectodermal tumor 5 | 3,031
Peripheral Neuropathy 4 | 303
Waldenstrons macroglobulinemia 4 | 765
cutaneous lupus erythematosus 4 | 1,056
dermatomyositis 4 | 967
gastric cancer 4 | 436
pancreatic carcinoma 4 | 567
pituitary cancer 4 | 1,972
posterior fossa group A ependymoma 4 | 1,511
sonic hedgehog group medulloblastoma 4 | 1,482
spina bifida 4 | 1,064
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
Mammary Neoplasms 3 | 410
Treacher Collins syndrome 3 | 29
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 5
acute quadriplegic myopathy 3 | 1,157
astrocytic glioma 3 | 2,241
hepatocellular carcinoma 3 | 550
oligodendroglioma 3 | 2,849
pilocytic astrocytoma 3 | 3,086
Arsenic Poisoning 2 | 59
Baller-Gerold syndrome 2 | 14
Carcinoma 2 | 2,147
Dermatologic disorders 2 | 65
Endometriosis 2 | 535
Franceschetti-Klein syndrome 2 | 3
Mandibulofacial Dysostosis 2 | 3
Orchitis 2 | 16
Rheumatoid Arthritis 2 | 1,171
Rothmund-Thomson syndrome 2 | 22
Stomach Neoplasms 2 | 282
Thyroiditis 2 | 25
Treacher Collins syndrome 1 2 | 3
Vaccinia 2 | 37
Warsaw breakage syndrome 2 | 12
Werner syndrome 2 | 29
Xeroderma pigmentosum-Cockayne syndrome complex 2 | 4
active Crohn's disease 2 | 918
aldosterone-producing adenoma 2 | 664
astrocytoma 2 | 1,493
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299
lung carcinoma 2 | 2,844
medulloblastoma 2 | 1,524
non primary Sjogren syndrome sicca 2 | 840
primary pancreatic ductal adenocarcinoma 2 | 1,271
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,563
Animal Mammary Neoplasms 1 | 136
Ankylosing spondylitis 1 | 138
Dystonia 1 | 77
Fanconi's anemia 1 | 50
Learning disability 1 | 20
Leukodystrophy 1 | 30
Mammary Neoplasms, Experimental 1 | 150
Muscular atrophy 1 | 67
Seckel syndrome 1 | 35
Squamous cell carcinoma 1 | 96
Squamous cell carcinoma of esophagus 1 | 82
Testicular cancer 1 | 24

Tissue

Female tissues 55 | 18,647
Male tissues 55 | 17,969
Blood and immune system 54 | 17,995
Cardiovascular System 54 | 17,958
Digestive Tract 54 | 18,473
Endocrine System 54 | 18,512
Nervous System 54 | 18,561
Urinary Tract 54 | 18,444
Liver and Pancreas 53 | 18,136
Respiratory system 53 | 17,484
Skin and soft tissues 47 | 18,115

Target Family

Non-IDG 32 | 11,969
Enzyme 20 | 4,146
Epigenetic 1 | 242
Kinase 1 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

RNA Polymerase I Chain Elongat... 55 | 55
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerases I and III subunit RPAC2 POLR1D Tbio Enzyme -1.71314 46.6 54
Histone H2A.J H2AFJ Tdark Non-IDG -0.03378 0.61 90
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
DNA-directed RNA polymerase I subunit RPA43 TWISTNB Tdark Enzyme -0.05799 0.64 59
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Cyclin-dependent kinase 7 CDK7 Tchem Kinase -2.32321 191.1 505
Cyclin-H CCNH Tbio Non-IDG -2.01404 89.8 354