Development Level

Tbio 80 | 10,625
Tdark 22 | 7,003
Tchem 9 | 1,890
Tclin 2 | 602

IMPC Phenotype

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 4 | 187
abnormal behavior 2 | 226
decreased body weight 2 | 174
decreased lumbar vertebrae num... 2 | 62
increased bone mineral content 2 | 92
increased sacral vertebrae num... 2 | 62
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal hair growth 1 | 8
abnormal humerus morphology 1 | 11
abnormal maxilla morphology 1 | 16
abnormal retina morphology 1 | 100
abnormal tooth morphology 1 | 24
decreased B cell number 1 | 30
decreased Ly6C low monocyte nu... 1 | 23
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating sodium l... 1 | 18
decreased erythrocyte cell num... 1 | 43
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
enlarged lymph nodes 1 | 27
enlarged urinary bladder 1 | 4
hypoactivity 1 | 89
increased circulating alkaline... 1 | 119
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased mean corpuscular hem... 1 | 93
increased mean platelet volume 1 | 19
increased plasma cell number 1 | 5
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

ovarian cancer 60 | 8,491
osteosarcoma 46 | 7,933
lung cancer 45 | 4,473
psoriasis 39 | 6,685
medulloblastoma, large-cell 24 | 6,234
glioblastoma 23 | 5,572
lung adenocarcinoma 23 | 2,714
Breast cancer 21 | 3,098
Cancer 20 | 2,346
Multiple myeloma 18 | 1,327
group 4 medulloblastoma 18 | 1,875
malignant mesothelioma 18 | 3,163
invasive ductal carcinoma 17 | 2,950
atypical teratoid / rhabdoid tumor 14 | 4,369
breast carcinoma 14 | 1,614
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
Pick disease 13 | 1,893
ependymoma 13 | 2,514
pediatric high grade glioma 13 | 2,712
primitive neuroectodermal tumor 13 | 3,031
group 3 medulloblastoma 12 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
non-small cell lung cancer 12 | 2,798
astrocytic glioma 11 | 2,241
diabetes mellitus 11 | 1,663
pancreatic cancer 11 | 2,300
Carcinoma 10 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
acute quadriplegic myopathy 9 | 1,157
astrocytoma 9 | 1,493
atypical teratoid/rhabdoid tumor 9 | 1,095
colon cancer 9 | 1,475
posterior fossa group A ependymoma 9 | 1,511
subependymal giant cell astrocytoma 9 | 2,287
Cockayne syndrome 8 | 54
Photosensitive trichothiodystrophy 8 | 24
acute myeloid leukemia 8 | 785
oligodendroglioma 8 | 2,849
sonic hedgehog group medulloblastoma 8 | 1,482
spina bifida 8 | 1,064
Rheumatoid Arthritis 7 | 1,170
cutaneous lupus erythematosus 7 | 1,056
nasopharyngeal carcinoma 7 | 1,056
pituitary cancer 7 | 1,972
tuberculosis 7 | 1,563
Endometriosis 6 | 535
Waldenstrons macroglobulinemia 6 | 764
Xeroderma pigmentosum 6 | 41
cystic fibrosis 6 | 1,670
dermatomyositis 6 | 966
lung carcinoma 6 | 2,844
non-small cell lung carcinoma 6 | 413
pilocytic astrocytoma 6 | 3,086
Intellectual disability 5 | 573
gastric cancer 5 | 436
gastric carcinoma 5 | 832
juvenile dermatomyositis 5 | 1,189
medulloblastoma 5 | 1,524
pancreatic carcinoma 5 | 567
primary pancreatic ductal adenocarcinoma 5 | 1,271
Cleft palate 4 | 125
Connective tissue disease 4 | 59
Leishmaniasis 4 | 49
Lupus erythematosus 4 | 80
Peripheral Neuropathy 4 | 303
Prostatic Neoplasms 4 | 471
Squamous cell carcinoma 4 | 96
Stomach Neoplasms 4 | 282
Treacher Collins syndrome 4 | 29
hepatocellular carcinoma 4 | 550
non primary Sjogren syndrome sicca 4 | 840
Alzheimer's disease 3 | 644
Cardiovascular system disease 3 | 194
Hypomyelination-hypogonadotropic-hypogonadism-hypodontia syndrome 3 | 3
Leukodystrophy 3 | 30
Lung Neoplasms 3 | 171
Mammary Neoplasms 3 | 410
Retinoblastoma 3 | 14
Tooth agenesis 3 | 38
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 5
active Crohn's disease 3 | 918
adrenocortical carcinoma 3 | 1,427
adult high grade glioma 3 | 2,148
ulcerative colitis 3 | 2,087
Atopic dermatitis 2 | 944
Cataract 2 | 104
Cocaine-Related Disorders 2 | 88
Down syndrome 2 | 548
Marshall-Smith syndrome 2 | 5
Parkinson's disease 2 | 364
Peripheral T-cell lymphoma 2 | 24
Primary cutaneous T-cell lymphoma 2 | 29
aldosterone-producing adenoma 2 | 664
glioblastoma multiforme 2 | 347
inflammatory breast cancer 2 | 404
progressive supranuclear palsy 2 | 674
urothelial carcinoma 2 | 318

Tissue

Female tissues 113 | 18,646
Male tissues 113 | 17,968
Blood and immune system 112 | 17,994
Cardiovascular System 112 | 17,957
Digestive Tract 112 | 18,472
Endocrine System 112 | 18,511
Nervous System 112 | 18,560
Urinary Tract 112 | 18,443
Liver and Pancreas 111 | 18,135
Respiratory system 111 | 17,483
Skin and soft tissues 105 | 18,114

Target Family

Non-IDG 50 | 11,969
Enzyme 35 | 4,146
Transcription Factor 17 | 1,400
Epigenetic 9 | 242
Kinase 2 | 634

Reactome Pathway

RNA Polymerase I, RNA Polymera... 113 | 113
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
DNA-directed RNA polymerase III subunit RPC7-like POLR3GL Tbio Enzyme -1.46920 28.5 54
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.14104 13.5 159
General transcription factor 3C polypeptide 1 GTF3C1 Tbio Non-IDG -2.19134 151.5 32
Zinc finger protein 143 ZNF143 Tbio Transcription Factor -2.46665 293.8 52
RNA polymerase I-specific transcription initiation factor RRN3 RRN3 Tbio Enzyme -1.47251 46.2 152