Development Level

Tbio 25 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to t... 3 | 278
embryonic lethality prior to o... 2 | 239
abnormal embryo size 1 | 220
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating sodium l... 1 | 22
embryonic growth retardation 1 | 106
increased anti-nuclear antigen... 1 | 19
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29

Disease

ovarian cancer 14 | 8,520
Carcinoma 11 | 11,493
Cockayne syndrome 10 | 60
Photosensitive trichothiodystrophy 9 | 30
osteosarcoma 9 | 7,950
lung cancer 8 | 4,740
Xeroderma pigmentosum group B 7 | 20
Xeroderma pigmentosum 5 | 43
psoriasis 5 | 6,694
Hereditary spherocytosis type 5 4 | 12
Kidney cancer 4 | 2,613
Multiple myeloma 4 | 1,332
Xeroderma pigmentosum group D 4 | 33
diabetes mellitus 4 | 1,728
glioblastoma 4 | 5,792
medulloblastoma, large-cell 4 | 6,241
Keratitis 3 | 62
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 6
Xeroderma pigmentosum group G 3 | 16
acute myeloid leukemia 3 | 783
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
group 4 medulloblastoma 3 | 1,855
Abnormally small eyeball 2 | 97
Arthralgia 2 | 90
Atrophic condition of skin 2 | 25
Autosomal recessive predisposition 2 | 1,442
Basal cell carcinoma 2 | 54
Basal cell nevi 2 | 23
Brittle hair 2 | 25
Cachexia 2 | 50
Cancer 2 | 2,499
Congenital Nonbullous Ichthyosiform Erythroderma 2 | 16
Congenital deafness 2 | 185
Conjunctival telangiectasis 2 | 14
Deafness 2 | 198
Decreased size of eyeball 2 | 97
Dental abnormalities 2 | 60
Developmental regression 2 | 95
Dry skin 2 | 75
Dull intelligence 2 | 645
Electroencephalogram abnormal 2 | 101
Erythema 2 | 58
Failure to gain weight 2 | 365
Fatigue 2 | 182
Fever 2 | 138
Flushing 2 | 60
Fractured hair 2 | 25
Fragile hair 2 | 25
Freckles 2 | 33
Hearing Loss, Partial 2 | 185
Hyperkeratosis 2 | 50
Hyperpigmented macules 2 | 42
Impaired cognition 2 | 96
Lens Opacities 2 | 231
Loss of developmental milestones 2 | 95
Low intelligence 2 | 645
Melanoma 2 | 711
Mental deficiency 2 | 645
Mental deterioration in childhood 2 | 95
Mental impairment 2 | 95
Mixed connective tissue disease 2 | 16
Muscle Spasticity 2 | 195
Neurodevelopmental regression 2 | 95
Papilloma 2 | 44
Pediatric failure to thrive 2 | 365
Peripheral demyelinating neuropathy 2 | 7
Photosensitivity of skin 2 | 51
Pick disease 2 | 1,894
Poikiloderma 2 | 14
Poor school performance 2 | 645
Precociously senile appearance 2 | 18
Progressive mental retardation 2 | 37
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Reduced tensile strength of hair 2 | 25
Retinal Diseases 2 | 55
Sensorineural Hearing Loss (disorder) 2 | 284
Short stature 2 | 531
Small head 2 | 374
Squamous cell carcinoma of skin 2 | 11
Strabismus 2 | 270
Telangiectasia of the skin 2 | 39
Thin skin 2 | 47
Tooth Abnormalities 2 | 69
Waldenstrons macroglobulinemia 2 | 765
Xeroderma pigmentosum group F 2 | 22
Xerosis 2 | 75
adult high grade glioma 2 | 3,801
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
hearing impairment 2 | 199
hepatocellular carcinoma 2 | 547
hypopigmented skin patch 2 | 59
pancreatic cancer 2 | 2,398
pancreatic carcinoma 2 | 562
primitive neuroectodermal tumor 2 | 3,035

Tissue

Blood and immune system 26 | 16,909
Cardiovascular System 26 | 15,192
Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Nervous System 26 | 16,725
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678

Target Family

Enzyme 16 | 4,145
Non-IDG 9 | 12,091
Kinase 1 | 634

Reactome Pathway

RNA Pol II CTD phosphorylation... 26 | 26
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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