Development Level

Tbio 11 | 11,445
Tchem 10 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal cornea morphology 1 | 31
abnormal skin condition 1 | 6
absent vibrissae 1 | 12
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating magnesiu... 1 | 10
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
premature death 1 | 5

Disease

Cancer 14 | 2,499
Carcinoma 12 | 11,493
ovarian cancer 10 | 8,520
glioblastoma 9 | 5,792
lung cancer 9 | 4,740
psoriasis 9 | 6,694
atypical teratoid / rhabdoid tumor 7 | 5,112
ependymoma 7 | 4,679
osteosarcoma 7 | 7,950
lung carcinoma 6 | 2,843
medulloblastoma, large-cell 6 | 6,241
oligodendroglioma 6 | 2,850
Arthritis 5 | 290
Asthma 5 | 385
Brain Ischemia 5 | 110
Immunologic Deficiency Syndromes 5 | 113
Kidney cancer 5 | 2,613
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
adult high grade glioma 5 | 3,801
primitive neuroectodermal tumor 5 | 3,035
tuberculosis 5 | 2,010
Alzheimer's disease 4 | 658
Astrocytoma, Pilocytic 4 | 3,081
Breast cancer 4 | 3,578
Inflammatory bowel disease 4 | 151
Multiple myeloma 4 | 1,332
astrocytoma 4 | 1,146
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
diabetes mellitus 4 | 1,728
group 3 medulloblastoma 4 | 4,104
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
subependymal giant cell astrocytoma 4 | 2,287
Brain disease 3 | 96
Cell Transformation, Neoplastic 3 | 97
Cholestasis, Extrahepatic 3 | 25
Heat Stroke 3 | 13
Hypersensitivity reaction type II disease 3 | 253
Hypertension 3 | 396
Influenza 3 | 142
Keratitis 3 | 62
Liver Cirrhosis, Experimental 3 | 769
Lung disease 3 | 142
Mantle cell lymphoma 3 | 23
Neoplastic Cell Transformation 3 | 89
Pick disease 3 | 1,894
Pneumonia 3 | 174
Reperfusion Injury 3 | 86
Splenomegaly 3 | 190
Vascular disease 3 | 319
astrocytic glioma 3 | 2,597
group 4 medulloblastoma 3 | 1,855
juvenile dermatomyositis 3 | 1,187
non-small cell lung cancer 3 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
ulcerative colitis 3 | 1,819
Alcoholic Intoxication, Chronic 2 | 289
Atherosclerosis 2 | 291
Atopic dermatitis 2 | 952
Brachycephaly 2 | 88
Broad cranium shape 2 | 88
Cerebrovascular disease 2 | 238
Colonic Neoplasms 2 | 142
Dementia 2 | 175
Depressive disorder 2 | 409
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Disease Models, Animal 2 | 155
Down syndrome 2 | 499
Elevated hepatic transaminases 2 | 81
Epilepsy 2 | 792
Frontal bossing 2 | 157
Hepatic enzyme increased 2 | 81
Highly variable severity 2 | 157
Infantile onset 2 | 238
Inflammation 2 | 120
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Mood Disorders 2 | 184
Multiple Sclerosis 2 | 540
Myocardial Ischemia 2 | 169
Neoplasm Invasiveness 2 | 161
Parkinson's disease 2 | 392
Peritonitis 2 | 43
Seizures 2 | 596
Sparse hair 2 | 59
Subclinical abnormal liver function tests 2 | 81
Thin, sparse hair 2 | 59
Toxic encephalopathy 2 | 141
Transaminases increased 2 | 81
Variable expressivity 2 | 157
Waldenstrons macroglobulinemia 2 | 765
Wide skull shape 2 | 88
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696

Tissue

Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678

Target Family

Non-IDG 10 | 12,091
Kinase 5 | 634
Transcription Factor 4 | 1,400
Enzyme 3 | 4,145

Reactome Pathway

RIP-mediated NFkB activation v... 22 | 22
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NF-kappa-B inhibitor-interacting Ras-like protein 1 NKIRAS1 Tbio Enzyme -0.82896 5.23 242
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.85807 734.3 204
Serum amyloid A-1 protein SAA1 Tbio Non-IDG -3.09466 1265.8 371
Z-DNA-binding protein 1 ZBP1 Tbio Non-IDG -2.36961 223.6 140
Protein S100-B S100B Tchem Non-IDG -3.48893 3193.2 903
Receptor-interacting serine/threonine-protein kinase 3 RIPK3 Tchem Kinase -2.22748 161.7 603
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.33991 211.8 375
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.26747 1795.4 672
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
NF-kappa-B inhibitor-interacting Ras-like protein 2 NKIRAS2 Tdark Enzyme -0.44341 2.26 157