Development Level

Tbio 56 | 10,625
Tchem 19 | 1,890
Tdark 4 | 7,003

IMPC Term

decreased bone mineral content 3 | 157
decreased grip strength 3 | 123
preweaning lethality, complete... 3 | 633
abnormal retinal pigmentation 2 | 61
decreased circulating fructosa... 2 | 31
decreased circulating sodium l... 2 | 18
decreased fasted circulating g... 2 | 49
decreased lean body mass 2 | 195
decreased mean corpuscular vol... 2 | 50
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased heart weight 1 | 44
decreased lymphocyte cell numb... 1 | 9
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
hypoactivity 1 | 89
increased KLRG1+ CD8 alpha bet... 1 | 2
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 24
increased circulating total pr... 1 | 20
increased heart weight 1 | 37
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased monocyte cell number 1 | 27
increased or absent threshold ... 1 | 128
increased thermal nociceptive ... 1 | 9
male infertility 1 | 62
polydactyly 1 | 22
premature death 1 | 5
small superior vagus ganglion 1 | 20
tremors 1 | 34

Disease

ovarian cancer 44 | 8,484
Cancer 36 | 2,346
psoriasis 34 | 6,685
osteosarcoma 33 | 7,933
glioblastoma 28 | 5,572
lung cancer 28 | 4,466
medulloblastoma, large-cell 22 | 6,234
juvenile dermatomyositis 20 | 1,189
atypical teratoid / rhabdoid tumor 17 | 4,369
Multiple myeloma 16 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
pilocytic astrocytoma 16 | 3,086
cutaneous lupus erythematosus 15 | 1,056
lung carcinoma 15 | 2,844
ependymoma 14 | 2,514
Influenza 13 | 142
Rheumatoid Arthritis 13 | 1,160
malignant mesothelioma 13 | 3,162
subependymal giant cell astrocytoma 13 | 2,287
Multiple Sclerosis 12 | 498
Melanoma 11 | 261
cystic fibrosis 11 | 1,665
dermatomyositis 11 | 933
oligodendroglioma 11 | 2,849
pediatric high grade glioma 11 | 2,712
astrocytic glioma 10 | 2,241
interstitial cystitis 10 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
primary Sjogren syndrome 10 | 789
tuberculosis 10 | 1,557
Breast cancer 9 | 3,094
acute quadriplegic myopathy 9 | 1,157
adult high grade glioma 9 | 2,148
non-small cell lung cancer 9 | 2,798
primitive neuroectodermal tumor 9 | 3,031
ulcerative colitis 9 | 2,087
Carcinoma 8 | 2,147
Mammary Neoplasms 8 | 410
astrocytoma 8 | 1,493
diabetes mellitus 8 | 1,663
esophageal adenocarcinoma 8 | 737
group 4 medulloblastoma 8 | 1,875
systemic lupus erythematosus 8 | 156
Pick disease 7 | 1,893
active Crohn's disease 7 | 918
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
invasive ductal carcinoma 7 | 2,950
lung adenocarcinoma 7 | 2,713
pituitary cancer 7 | 1,972
posterior fossa group A ependymoma 7 | 1,511
Arthritis 6 | 248
Hepatitis C 6 | 90
acute myeloid leukemia 6 | 780
glioblastoma multiforme 6 | 347
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
Atopic dermatitis 5 | 944
Bipolar Disorder 5 | 266
Crohn's disease 5 | 304
Neurodegenerative disease 5 | 383
medulloblastoma 5 | 1,524
pancreatic cancer 5 | 2,300
primary pancreatic ductal adenocarcinoma 5 | 1,271
Alzheimer's disease 4 | 644
Brain Ischemia 4 | 87
Gaucher disease type 1 4 | 171
Hepatitis 4 | 61
Inflammation 4 | 109
Inflammatory bowel disease 4 | 142
Liver carcinoma 4 | 217
Lymphoma, Follicular 4 | 20
Neoplastic Cell Transformation 4 | 81
breast carcinoma 4 | 1,614
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis and treatment for 6 months 4 | 686
Amyotrophic Lateral Sclerosis 3 | 431
Atherosclerosis 3 | 275
Bladder Neoplasm 3 | 109
Carcinoma, Transitional Cell 3 | 31
Dementia 3 | 129
Diabetes Mellitus, Non-Insulin-Dependent 3 | 157
Down syndrome 3 | 548
Hepatitis B 3 | 103
Hypersensitivity reaction type II disease 3 | 235
IGA Glomerulonephritis 3 | 454
Lung disease 3 | 132
Myocardial Ischemia 3 | 169
Pancreatic Neoplasm 3 | 79
Reperfusion Injury 3 | 84
Schizophrenia 3 | 501
Stomach Neoplasms 3 | 282
Toxic encephalopathy 3 | 131
Vascular disease 3 | 281
Waldenstrons macroglobulinemia 3 | 765
active ulcerative colitis 3 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
colon cancer 3 | 1,475
hepatocellular carcinoma 3 | 532
non-small cell lung carcinoma 3 | 413
progressive supranuclear palsy 3 | 674
spina bifida 3 | 1,064

Tissue

Nervous System 79 | 18,561
Digestive Tract 77 | 18,473
Female tissues 77 | 18,647
Urinary Tract 77 | 18,444
Skin and soft tissues 74 | 18,115
Blood and immune system 73 | 17,995
Endocrine System 73 | 18,512
Cardiovascular System 72 | 17,958
Liver and Pancreas 72 | 18,136
Respiratory system 69 | 17,484
Male tissues 68 | 17,969

Target Family

Non-IDG 46 | 11,971
Enzyme 16 | 4,146
Transcription Factor 8 | 1,400
Kinase 7 | 634
Epigenetic 2 | 242

Reactome Pathway

RIG-I/MDA5 mediated induction ... 79 | 79
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34160 1960.9 1181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Ubiquitin-conjugating enzyme E2 D2 UBE2D2 Tbio Non-IDG -2.06903 107.6 211
Ubiquitin-conjugating enzyme E2 D3 UBE2D3 Tbio Non-IDG -1.23367 18.0 133
Ubiquitin-conjugating enzyme E2 K UBE2K Tbio Non-IDG -2.28277 146.6 299
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.80890 693.7 191
NF-kappa-B essential modulator IKBKG Tchem Kinase -3.03588 1121.7 849
Interferon alpha-7 IFNA7 Tdark Non-IDG -0.67991 3.90 46