Development Level

Tbio 36 | 11,445
Tchem 12 | 1,598
Tdark 9 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
decreased neutrophil cell numb... 2 | 42
edema 2 | 59
improved glucose tolerance 2 | 79
abnormal bone structure 1 | 187
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
cardiovascular system phenotyp... 1 | 36
decreased bone mineral content 1 | 151
decreased circulating serum al... 1 | 82
decreased circulating unsatura... 1 | 2
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating triglyce... 1 | 42
increased heart rate variabili... 1 | 7
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19

Disease

ovarian cancer 32 | 8,520
psoriasis 29 | 6,694
Carcinoma 27 | 11,493
Breast cancer 23 | 3,578
osteosarcoma 23 | 7,950
atypical teratoid / rhabdoid tumor 22 | 5,112
lung cancer 22 | 4,740
glioblastoma 20 | 5,792
medulloblastoma, large-cell 20 | 6,241
Cancer 19 | 2,499
lung adenocarcinoma 19 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
invasive ductal carcinoma 14 | 2,951
non-small cell lung cancer 14 | 2,890
group 4 medulloblastoma 13 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
malignant mesothelioma 13 | 3,232
pancreatic cancer 13 | 2,398
Multiple myeloma 12 | 1,332
adult high grade glioma 12 | 3,801
breast carcinoma 12 | 1,638
ductal carcinoma in situ 12 | 1,745
ependymoma 12 | 4,679
cystic fibrosis 11 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
colon cancer 10 | 1,478
Astrocytoma, Pilocytic 9 | 3,081
subependymal giant cell astrocytoma 9 | 2,287
Breast Neoplasms 8 | 445
diabetes mellitus 8 | 1,728
group 3 medulloblastoma 8 | 4,104
primary pancreatic ductal adenocarcinoma 8 | 1,109
Kidney cancer 7 | 2,613
Pick disease 7 | 1,894
Waldenstrons macroglobulinemia 7 | 765
lung carcinoma 7 | 2,843
oligodendroglioma 7 | 2,850
primitive neuroectodermal tumor 7 | 3,035
Mammary Neoplasms 6 | 425
Schizophrenia 6 | 1,160
acute quadriplegic myopathy 6 | 1,158
astrocytic glioma 6 | 2,597
dermatomyositis 6 | 966
astrocytoma 5 | 1,146
cutaneous lupus erythematosus 5 | 1,057
interstitial cystitis 5 | 2,312
juvenile dermatomyositis 5 | 1,187
non-small cell lung carcinoma 5 | 317
pancreatic carcinoma 5 | 562
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pediatric high grade glioma 5 | 1,064
pituitary cancer 5 | 1,972
spina bifida 5 | 1,074
Bipolar Disorder 4 | 666
Crohn's disease 4 | 321
Neoplasm Invasiveness 4 | 161
Parkinson's disease 4 | 392
Prostatic Neoplasms 4 | 495
active ulcerative colitis 4 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
medulloblastoma 4 | 720
Cleft Palate 3 | 271
Connective tissue disease 3 | 62
Down syndrome 3 | 499
Duchenne muscular dystrophy 3 | 601
Endometriosis 3 | 540
Impotence 3 | 42
Liver Cirrhosis, Experimental 3 | 769
Lupus erythematosus 3 | 57
Neoplasm Metastasis 3 | 168
Neoplasm Recurrence, Local 3 | 37
Primary cutaneous amyloidosis 3 | 29
Prostate cancer 3 | 175
Proteinuria 3 | 144
Rheumatoid arthritis 3 | 1,191
gastric cancer 3 | 459
progressive supranuclear palsy 3 | 676
ulcerative colitis 3 | 1,819
Atopic dermatitis 2 | 952
Carcinoma, Hepatocellular 2 | 228
Cerebrovascular disease 2 | 238
Disease Progression 2 | 136
Focal glomerulosclerosis 2 | 37
Glomerulosclerosis, Focal Segmental 2 | 28
Hypertension 2 | 396
Kidney disease 2 | 430
Liver cancer 2 | 604
Liver carcinoma 2 | 240
Multiple Sclerosis 2 | 540
Skin cancer 2 | 469
acute myeloid leukemia 2 | 783
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
limb girdle muscular dystrophy 2I 2 | 32
nasopharyngeal carcinoma 2 | 1,058
non diabetic and post-ischemic heart failure 2 | 200
sonic hedgehog group medulloblastoma 2 | 467
tuberculosis 2 | 2,010

Tissue

Endocrine System 57 | 18,159
Blood and immune system 56 | 16,909
Digestive Tract 56 | 17,369
Female tissues 56 | 17,400
Skin and soft tissues 56 | 17,230
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Nervous System 55 | 16,725
Respiratory system 55 | 16,393
Urinary Tract 55 | 16,678
Cardiovascular System 54 | 15,192

Target Family

Non-IDG 39 | 12,091
Enzyme 11 | 4,145
Kinase 5 | 634
Epigenetic 2 | 242

Reactome Pathway

RHO GTPases activate PKNs 57 | 57
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Serine/threonine-protein kinase N3 PKN3 Tbio Kinase -1.19026 15.5 133
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.27041 18.5 133
Histone H2A.J H2AFJ Tdark Non-IDG -0.00172 0.83 99
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 16
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.38165 22.7 117
Histone H2A.V H2AFV Tdark Non-IDG -1.18642 15.1 40