Development Level

Tbio 9 | 11,651
Tdark 1 | 6,593

IMPC Phenotype

abnormal embryo size 1 | 220
absent pinna reflex 1 | 23
cyanosis 1 | 7
impaired pupillary reflex 1 | 26
increased or absent threshold ... 1 | 101
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 9 | 11,493
osteosarcoma 8 | 7,950
ovarian cancer 8 | 8,520
astrocytoma 4 | 1,146
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
psoriasis 4 | 6,694
Neurodegenerative disease 3 | 414
Rheumatoid arthritis 3 | 1,191
Waldenstrons macroglobulinemia 3 | 765
diabetes mellitus 3 | 1,728
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
Astrocytoma, Pilocytic 2 | 3,081
Kidney cancer 2 | 2,613
Multiple myeloma 2 | 1,332
Neuropathy 2 | 261
Paraplegia 2 | 74
Pick disease 2 | 1,894
SPOAN syndrome 2 | 2
dermatomyositis 2 | 966
group 4 medulloblastoma 2 | 1,855
hereditary spastic paraplegia 2 | 318
medulloblastoma, large-cell 2 | 6,241
oligodendroglioma 2 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
primitive neuroectodermal tumor 2 | 3,035
progressive supranuclear palsy 2 | 676
subependymal giant cell astrocytoma 2 | 2,287
Acquired scoliosis 1 | 281
Adenocarcinoma 1 | 122
Alzheimer's disease 1 | 658
Angioimmunoblastic Lymphadenopathy 1 | 4
Ankle clonus 1 | 6
Atherosclerosis 1 | 291
Babinski Reflex 1 | 100
Bladder Neoplasm 1 | 112
Cancer 1 | 2,499
Carcinoma, Hepatocellular 1 | 228
Carcinoma, Non-Small-Cell Lung 1 | 107
Cardiomyopathy, Dilated 1 | 83
Cerebrovascular disease 1 | 238
Congenital pes cavus 1 | 88
Curvature of spine 1 | 282
Decreased lower limb vibratory sense 1 | 13
Depressive disorder 1 | 409
Disease Models, Animal 1 | 155
Distal sensory impairment 1 | 52
Down syndrome 1 | 499
Endometrial cancer 1 | 311
Epilepsy 1 | 792
Heart disease 1 | 306
Heart failure 1 | 162
Highly variable clinical phenotype 1 | 150
Highly variable phenotype and severity 1 | 150
Highly variable phenotype, even within families 1 | 150
Hyperreflexia 1 | 209
Hypertension 1 | 396
Immunoblastic Lymphadenopathy 1 | 4
Impotence 1 | 46
Kidney disease 1 | 430
Liver Cirrhosis, Experimental 1 | 769
Liver carcinoma 1 | 240
Liver diseases 1 | 87
Lung disease 1 | 142
Lymphoma, T-Cell, Cutaneous 1 | 22
Melanoma 1 | 711
Mental Depression 1 | 333
Monoparesis - leg 1 | 27
Neoplasm Invasiveness 1 | 161
Neoplasm Metastasis 1 | 168
Overactive bladder syndrome 1 | 14
Paratyphoid fever 1 | 10
Peripheral T-cell lymphoma 1 | 25
Phenotypic variability 1 | 150
Progressive disorder 1 | 142
Proteinuria 1 | 144
Retinitis pigmentosa 47 1 | 4
Seborrheic dermatitis 1 | 31
Skin cancer 1 | 469
Spastic Paraplegia 1 | 42
Spastic gait 1 | 23
Sphincter disturbances 1 | 16
Stomach Neoplasms 1 | 300
Urgency frequency syndrome 1 | 14
Urgency of micturition 1 | 14
Urinary Bladder Neoplasms 1 | 114
Urinary Incontinence 1 | 50
Weakness of lower limb 1 | 27
acute quadriplegic myopathy 1 | 1,158
chorea-acanthocytosis 1 | 12
facioscapulohumeral dystrophy 1 | 288
mucosa-associated lymphoid tissue lymphoma 1 | 484
non-small cell lung carcinoma 1 | 317
pancreatic carcinoma 1 | 562
primary pancreatic ductal adenocarcinoma 1 | 1,109
spina bifida 1 | 1,074

Tissue

Blood and immune system 10 | 16,909
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678
Cardiovascular System 9 | 15,192

Target Family

Non-IDG 7 | 12,091
Enzyme 3 | 4,145

Reactome Pathway

RHO GTPases activate KTN1 10 | 10
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Kinesin light chain 2 KLC2 Tbio Non-IDG -0.71842 5.05 153
Transforming protein RhoA RHOA Tbio Enzyme -3.54095 3332.7 501
Kinesin light chain 1 KLC1 Tbio Non-IDG -2.17598 25.5 180
Rho-related GTP-binding protein RhoG RHOG Tbio Enzyme -2.04297 108.1 142
Kinesin-1 heavy chain KIF5B Tbio Non-IDG -2.32485 196.1 326
Kinectin KTN1 Tbio Non-IDG -1.93411 83.4 89
Kinesin light chain 3 KLC3 Tbio Non-IDG -1.01551 11.4 98
Kinesin heavy chain isoform 5A KIF5A Tbio Non-IDG -1.69131 48.4 170
Kinesin light chain 4 KLC4 Tdark Non-IDG -0.14930 1.10 46