Development Level

Tbio 86 | 10,625
Tchem 16 | 1,890
Tdark 8 | 7,003
Tclin 2 | 602

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 15 | 633
embryonic lethality prior to t... 6 | 187
increased fasted circulating g... 5 | 68
embryonic lethality prior to o... 4 | 148
decreased circulating iron lev... 3 | 25
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal coat-hair pigmentatio... 2 | 54
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
decreased circulating free fat... 2 | 39
decreased mean corpuscular vol... 2 | 50
decreased total body fat amoun... 2 | 186
embryonic growth retardation 2 | 28
increased circulating iron lev... 2 | 25
increased or absent threshold ... 2 | 128
abnormal craniofacial morpholo... 1 | 12
abnormal embryo turning 1 | 15
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal motor learning 1 | 4
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 11
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal placenta vasculature 1 | 2
abnormal retinal pigmentation 1 | 61
abnormal skin coloration 1 | 18
abnormal testis morphology 1 | 30
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased neutrophil cell numb... 1 | 37
decreased startle reflex 1 | 48
fused cornea and lens 1 | 4
hypoactivity 1 | 89
improved glucose tolerance 1 | 56
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating glucose ... 1 | 16
increased grip strength 1 | 83
increased mean corpuscular hem... 1 | 25
increased neutrophil cell numb... 1 | 15
increased sacral vertebrae num... 1 | 62
increased thermal nociceptive ... 1 | 9
male infertility 1 | 62
narrow eye opening 1 | 15
pallor 1 | 13
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
small testis 1 | 37

Disease

ovarian cancer 74 | 8,491
medulloblastoma, large-cell 65 | 6,234
glioblastoma 63 | 5,572
osteosarcoma 58 | 7,933
psoriasis 56 | 6,685
lung cancer 54 | 4,473
primitive neuroectodermal tumor 46 | 3,031
pediatric high grade glioma 44 | 2,712
atypical teratoid / rhabdoid tumor 42 | 4,369
non-small cell lung cancer 42 | 2,798
group 3 medulloblastoma 41 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,289
malignant mesothelioma 40 | 3,163
Breast cancer 39 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
adrenocortical carcinoma 34 | 1,427
invasive ductal carcinoma 31 | 2,950
lung adenocarcinoma 31 | 2,714
Cancer 28 | 2,346
breast carcinoma 24 | 1,614
pancreatic cancer 24 | 2,300
colon cancer 23 | 1,475
ductal carcinoma in situ 23 | 1,745
posterior fossa group A ependymoma 23 | 1,511
Endometriosis 21 | 535
oligodendroglioma 21 | 2,849
nasopharyngeal carcinoma 20 | 1,056
Multiple myeloma 18 | 1,327
Atopic dermatitis 17 | 944
atypical teratoid/rhabdoid tumor 17 | 1,095
pilocytic astrocytoma 17 | 3,086
sonic hedgehog group medulloblastoma 17 | 1,482
IGA Glomerulonephritis 16 | 454
Carcinoma 15 | 2,147
Waldenstrons macroglobulinemia 15 | 764
dermatomyositis 15 | 966
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
Pick disease 14 | 1,893
ependymoma 14 | 2,514
subependymal giant cell astrocytoma 14 | 2,287
astrocytic glioma 13 | 2,241
Rheumatoid Arthritis 12 | 1,170
acute quadriplegic myopathy 11 | 1,157
ulcerative colitis 11 | 2,087
interstitial cystitis 10 | 2,299
lung carcinoma 10 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
pituitary cancer 10 | 1,972
tuberculosis 10 | 1,563
adult high grade glioma 9 | 2,148
astrocytoma 9 | 1,493
group 4 medulloblastoma 9 | 1,875
posterior fossa group B ependymoma 9 | 1,530
Intellectual disability 8 | 573
gastric carcinoma 8 | 832
inflammatory breast cancer 8 | 404
medulloblastoma 8 | 1,524
primary Sjogren syndrome 8 | 788
active Crohn's disease 7 | 918
primary pancreatic ductal adenocarcinoma 7 | 1,271
Lissencephaly 6 | 61
Schizophrenia 6 | 503
acute myeloid leukemia 6 | 785
hereditary spastic paraplegia 6 | 313
Chondrosarcoma 5 | 24
Down syndrome 5 | 548
Microcephaly 5 | 149
juvenile dermatomyositis 5 | 1,189
Mammary Neoplasms 4 | 410
Myocardial Ischemia 4 | 169
Neoplasm Invasiveness 4 | 127
Roberts syndrome 4 | 16
Stomach Neoplasms 4 | 282
cutaneous lupus erythematosus 4 | 1,056
cystic fibrosis 4 | 1,670
cystic fibrosis and chronic rhinosinusitis 4 | 213
pancreatic carcinoma 4 | 567
spina bifida 4 | 1,064
tuberculosis and treatment for 6 months 4 | 686
Alzheimer's disease 3 | 644
Animal Mammary Neoplasms 3 | 135
Bipolar Disorder 3 | 266
Colorectal Neoplasms 3 | 217
Gaucher disease type 1 3 | 171
Heart disease 3 | 279
Kidney disease 3 | 397
Liver carcinoma 3 | 217
Lung Neoplasms 3 | 171
Neurodegenerative disease 3 | 383
Nonsyndromic deafness 3 | 121
Osteoporosis 3 | 259
Squamous cell carcinoma of esophagus 3 | 82
Vascular disease 3 | 281
aldosterone-producing adenoma 3 | 664
chronic rhinosinusitis 3 | 512
diabetes mellitus 3 | 1,663
esophageal adenocarcinoma 3 | 737
non-small cell lung carcinoma 3 | 413
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 3 months 3 | 327

Tissue

Blood and immune system 112 | 17,994
Cardiovascular System 112 | 17,957
Digestive Tract 112 | 18,472
Endocrine System 112 | 18,511
Female tissues 112 | 18,646
Liver and Pancreas 112 | 18,135
Male tissues 112 | 17,968
Nervous System 112 | 18,560
Urinary Tract 112 | 18,443
Respiratory system 111 | 17,483
Skin and soft tissues 111 | 18,114

Target Family

Non-IDG 84 | 11,969
Enzyme 21 | 4,146
Kinase 6 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

RHO GTPases Activate Formins 112 | 112
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitotic checkpoint serine/threonine-protein kinase BUB1 BUB1 Tchem Kinase -2.28810 192.8 356
Mitotic checkpoint protein BUB3 BUB3 Tbio Non-IDG -1.91281 73.2 222
Protein ELYS AHCTF1 Tbio Non-IDG -1.33445 22.8 57
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395
Nuclear pore complex protein Nup85 NUP85 Tbio Non-IDG -1.18826 15.9 128
Centromere/kinetochore protein zw10 homolog ZW10 Tbio Non-IDG -1.61249 40.5 115
Formin-like protein 1 FMNL1 Tbio Non-IDG -1.45588 23.0 103
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform PPP2R1A Tbio Enzyme -1.40388 25.3 259
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 17.1 179
Kinesin-like protein KIF2B KIF2B Tbio Non-IDG -0.63375 3.80 100