Development Level

Tbio 99 | 11,651
Tchem 12 | 1,388
Tdark 6 | 6,593
Tclin 2 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 21 | 979
embryonic lethality prior to t... 8 | 278
embryonic lethality prior to o... 6 | 239
preweaning lethality, incomple... 5 | 499
abnormal embryo size 4 | 220
embryonic growth retardation 4 | 106
increased fasted circulating g... 4 | 76
abnormal behavior 3 | 298
decreased circulating choleste... 3 | 93
prenatal lethality prior to he... 3 | 87
abnormal bone structure 2 | 187
abnormal skin coloration 2 | 25
abnormal tail morphology 2 | 25
cataract 2 | 92
decreased circulating free fat... 2 | 31
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased heart left ventricle... 2 | 28
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating iron lev... 2 | 30
increased neutrophil cell numb... 2 | 46
pallor 2 | 34
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal motor learning 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal placenta morphology 1 | 5
abnormal placenta size 1 | 20
abnormal placenta vasculature 1 | 2
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
fused cornea and lens 1 | 5
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
long tibia 1 | 25
male infertility 1 | 123
microphthalmia 1 | 26
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58
syndactyly 1 | 23

Disease

Carcinoma 83 | 11,493
ovarian cancer 78 | 8,520
medulloblastoma, large-cell 67 | 6,241
glioblastoma 66 | 5,792
osteosarcoma 62 | 7,950
atypical teratoid / rhabdoid tumor 61 | 5,112
group 3 medulloblastoma 61 | 4,104
lung cancer 58 | 4,740
psoriasis 58 | 6,694
Breast cancer 48 | 3,578
primitive neuroectodermal tumor 47 | 3,035
non-small cell lung cancer 44 | 2,890
ependymoma 43 | 4,679
malignant mesothelioma 43 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
adult high grade glioma 40 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
adrenocortical carcinoma 37 | 1,428
invasive ductal carcinoma 33 | 2,951
lung adenocarcinoma 30 | 2,716
Cancer 27 | 2,499
breast carcinoma 25 | 1,638
pancreatic cancer 25 | 2,398
colon cancer 24 | 1,478
ductal carcinoma in situ 24 | 1,745
Endometriosis 23 | 540
oligodendroglioma 22 | 2,850
Kidney cancer 21 | 2,613
nasopharyngeal carcinoma 21 | 1,058
Astrocytoma, Pilocytic 18 | 3,081
Atopic dermatitis 18 | 952
Multiple myeloma 18 | 1,332
Pick disease 16 | 1,894
Waldenstrons macroglobulinemia 16 | 765
subependymal giant cell astrocytoma 16 | 2,287
astrocytic glioma 15 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
pediatric high grade glioma 15 | 1,064
Intellectual disability 14 | 1,016
dermatomyositis 14 | 966
tuberculosis 14 | 2,010
acute quadriplegic myopathy 13 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Rheumatoid arthritis 11 | 1,191
lung carcinoma 11 | 2,843
ulcerative colitis 11 | 1,819
interstitial cystitis 10 | 2,312
pituitary cancer 10 | 1,972
Cognitive delay 9 | 608
Dull intelligence 9 | 645
Global developmental delay 9 | 608
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Poor school performance 9 | 645
Small head 9 | 374
astrocytoma 9 | 1,146
Epilepsy 8 | 792
Seizures 8 | 596
gastric carcinoma 8 | 807
juvenile dermatomyositis 8 | 1,187
Lissencephaly 7 | 69
Microcephaly 7 | 166
Schizophrenia 7 | 1,160
active Crohn's disease 7 | 922
acute myeloid leukemia 7 | 783
group 4 medulloblastoma 7 | 1,855
medulloblastoma 7 | 720
primary Sjogren syndrome 7 | 735
Autosomal recessive predisposition 6 | 1,442
Downward slant of palpebral fissure 6 | 158
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Orbital separation excessive 6 | 244
Short stature 6 | 531
Stomach Neoplasms 6 | 300
hereditary spastic paraplegia 6 | 318
Cerebellar Hypoplasia 5 | 61
Dilated ventricles (finding) 5 | 121
Lymphoid leukemia 5 | 160
cutaneous lupus erythematosus 5 | 1,057
posterior fossa group A ependymoma 5 | 468
primary pancreatic ductal adenocarcinoma 5 | 1,109
tuberculosis and treatment for 6 months 5 | 409
Anteverted nostril 4 | 191
Congenital Epicanthus 4 | 177
Down syndrome 4 | 499
Glaucoma 4 | 239
Heart disease 4 | 306
Liver Cirrhosis, Experimental 4 | 769
Liver cancer 4 | 604
Neurodegenerative disease 4 | 414
Pachygyria 4 | 41
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
hepatocellular carcinoma 4 | 547
pancreatic carcinoma 4 | 562
spina bifida 4 | 1,074

Tissue

Endocrine System 118 | 18,159
Blood and immune system 117 | 16,909
Digestive Tract 117 | 17,369
Female tissues 117 | 17,400
Liver and Pancreas 117 | 16,750
Male tissues 117 | 17,142
Nervous System 117 | 16,725
Respiratory system 117 | 16,393
Skin and soft tissues 117 | 17,230
Urinary Tract 117 | 16,678
Cardiovascular System 114 | 15,192

Target Family

Non-IDG 91 | 12,091
Enzyme 21 | 4,145
Kinase 6 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

RHO GTPases Activate Formins 119 | 119
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Formin-like protein 2 FMNL2 Tbio Non-IDG -1.22907 18.1 74
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Centromere protein O CENPO Tbio Non-IDG -0.67552 5.22 124
Centromere/kinetochore protein zw10 homolog ZW10 Tbio Non-IDG -1.64269 41.5 124
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Histone H3-like centromeric protein A CENPA Tbio Non-IDG -2.73322 567.0 386
Polyamine-modulated factor 1 PMF1 Tbio Non-IDG -0.62754 4.93 133
Mitotic checkpoint serine/threonine-protein kinase BUB1 BUB1 Tchem Kinase -2.31533 200.0 373
Mitotic checkpoint protein BUB3 BUB3 Tbio Non-IDG -1.93368 76.1 256