Development Level

Tbio 192 | 11,651
Tchem 40 | 1,388
Tdark 17 | 6,593
Tclin 8 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 37 | 979
preweaning lethality, incomple... 10 | 499
embryonic lethality prior to t... 8 | 278
abnormal behavior 7 | 298
embryonic lethality prior to o... 6 | 239
abnormal embryo size 5 | 220
decreased circulating serum al... 5 | 82
decreased total body fat amoun... 5 | 207
edema 5 | 59
embryonic growth retardation 5 | 106
abnormal bone structure 4 | 187
cataract 4 | 92
decreased body weight 4 | 161
decreased grip strength 4 | 116
hypoactivity 4 | 132
increased fasted circulating g... 4 | 76
increased mean corpuscular vol... 4 | 92
prenatal lethality prior to he... 4 | 87
short tibia 4 | 97
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
abnormal skin coloration 3 | 25
decreased bone mineral content 3 | 151
decreased circulating choleste... 3 | 93
decreased neutrophil cell numb... 3 | 42
improved glucose tolerance 3 | 79
increased circulating HDL chol... 3 | 80
increased total body fat amoun... 3 | 134
small testis 3 | 58
abnormal coat-hair pigmentatio... 2 | 64
abnormal cornea morphology 2 | 31
abnormal heart morphology 2 | 162
abnormal pericardium morpholog... 2 | 26
abnormal placenta size 2 | 20
abnormal skin morphology 2 | 50
abnormal tail morphology 2 | 25
abnormal testis morphology 2 | 43
decreased blood urea nitrogen ... 2 | 51
decreased circulating amylase ... 2 | 28
decreased circulating bilirubi... 2 | 19
decreased circulating free fat... 2 | 31
decreased circulating fructosa... 2 | 30
decreased circulating iron lev... 2 | 32
decreased circulating triglyce... 2 | 79
decreased heart left ventricle... 2 | 28
decreased mean corpuscular vol... 2 | 79
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating amylase ... 2 | 25
increased circulating chloride... 2 | 41
increased circulating iron lev... 2 | 30
increased lean body mass 2 | 172
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
increased startle reflex 2 | 112
long tibia 2 | 25
pallor 2 | 34
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal startle reflex 1 | 15
absent pinna reflex 1 | 23
decreased caudal vertebrae num... 1 | 53
decreased circulating chloride... 1 | 30
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
small kidney 1 | 16
small spleen 1 | 19
stereotypic behavior 1 | 3
syndactyly 1 | 23
tremors 1 | 39
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 169 | 11,493
ovarian cancer 166 | 8,520
osteosarcoma 133 | 7,950
glioblastoma 131 | 5,792
psoriasis 129 | 6,694
medulloblastoma, large-cell 126 | 6,241
atypical teratoid / rhabdoid tumor 123 | 5,112
lung cancer 111 | 4,740
Breast cancer 99 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 85 | 3,291
group 3 medulloblastoma 84 | 4,104
adult high grade glioma 81 | 3,801
ependymoma 81 | 4,679
primitive neuroectodermal tumor 79 | 3,035
non-small cell lung cancer 78 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 76 | 2,989
invasive ductal carcinoma 73 | 2,951
Cancer 70 | 2,499
malignant mesothelioma 70 | 3,232
lung adenocarcinoma 65 | 2,716
pancreatic cancer 61 | 2,398
Kidney cancer 56 | 2,613
Astrocytoma, Pilocytic 53 | 3,081
adrenocortical carcinoma 51 | 1,428
breast carcinoma 51 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 49 | 2,955
ductal carcinoma in situ 47 | 1,745
subependymal giant cell astrocytoma 46 | 2,287
oligodendroglioma 43 | 2,850
colon cancer 42 | 1,478
lung carcinoma 37 | 2,843
astrocytic glioma 36 | 2,597
Multiple myeloma 35 | 1,332
Pick disease 35 | 1,894
group 4 medulloblastoma 33 | 1,855
Endometriosis 32 | 540
Waldenstrons macroglobulinemia 32 | 765
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,962
interstitial cystitis 31 | 2,312
Atopic dermatitis 28 | 952
tuberculosis 28 | 2,010
ulcerative colitis 28 | 1,819
juvenile dermatomyositis 27 | 1,187
pediatric high grade glioma 27 | 1,064
astrocytoma 26 | 1,146
cystic fibrosis 26 | 1,696
dermatomyositis 26 | 966
nasopharyngeal carcinoma 26 | 1,058
Rheumatoid arthritis 25 | 1,191
diabetes mellitus 25 | 1,728
Schizophrenia 24 | 1,160
acute quadriplegic myopathy 24 | 1,158
primary pancreatic ductal adenocarcinoma 24 | 1,109
Intellectual disability 23 | 1,016
cutaneous lupus erythematosus 23 | 1,057
pituitary cancer 21 | 1,972
Breast Neoplasms 20 | 445
medulloblastoma 20 | 720
Liver Cirrhosis, Experimental 19 | 769
primary Sjogren syndrome 19 | 735
Mammary Neoplasms 18 | 425
spina bifida 18 | 1,074
Small head 16 | 374
Cognitive delay 15 | 608
Dull intelligence 15 | 645
Epilepsy 15 | 792
Global developmental delay 15 | 608
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental and motor retardation 15 | 608
Mental deficiency 15 | 645
Poor school performance 15 | 645
Neoplasm Invasiveness 14 | 161
hereditary spastic paraplegia 14 | 318
Alzheimer's disease 13 | 658
Autosomal recessive predisposition 13 | 1,442
Bipolar Disorder 13 | 666
Duchenne muscular dystrophy 13 | 601
Seizures 13 | 596
acute myeloid leukemia 13 | 783
gastric carcinoma 13 | 807
pancreatic carcinoma 13 | 562
Kidney disease 12 | 430
Short stature 12 | 531
Wiskott-Aldrich syndrome 12 | 30
posterior fossa group A ependymoma 12 | 468
Liver cancer 11 | 604
Stomach Neoplasms 11 | 300
active Crohn's disease 11 | 922
esophageal adenocarcinoma 11 | 737
hepatocellular carcinoma 11 | 547
non-small cell lung carcinoma 11 | 317
Carcinoma, Hepatocellular 10 | 228
Endometrial cancer 10 | 311
Hypertension 10 | 396
Lissencephaly 10 | 69
Liver carcinoma 10 | 240
Prostatic Neoplasms 10 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 510
progressive supranuclear palsy 10 | 676

Tissue

Endocrine System 255 | 18,159
Digestive Tract 252 | 17,369
Female tissues 252 | 17,400
Skin and soft tissues 252 | 17,230
Blood and immune system 251 | 16,909
Male tissues 251 | 17,142
Nervous System 251 | 16,725
Liver and Pancreas 250 | 16,750
Respiratory system 250 | 16,393
Urinary Tract 250 | 16,678
Cardiovascular System 242 | 15,192

Target Family

Non-IDG 186 | 12,091
Enzyme 39 | 4,145
Kinase 26 | 634
Epigenetic 2 | 242
Ion Channel 2 | 344
Nuclear Receptor 1 | 48
Transcription Factor 1 | 1,400

Reactome Pathway

RHO GTPase Effectors 257 | 257
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Formin-like protein 2 FMNL2 Tbio Non-IDG -1.22907 18.1 74
LIM domain kinase 2 LIMK2 Tchem Kinase -1.65006 41.3 405
NADPH oxidase 1 NOX1 Tchem Enzyme -2.59188 397.6 233
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Centromere protein O CENPO Tbio Non-IDG -0.67552 5.22 124
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482