Development Level

Tbio 168 | 10,625
Tchem 51 | 1,890
Tdark 22 | 7,003
Tclin 8 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 19 | 633
decreased body weight 6 | 174
embryonic lethality prior to t... 6 | 187
abnormal retina morphology 5 | 100
decreased total body fat amoun... 5 | 186
increased fasted circulating g... 5 | 68
preweaning lethality, incomple... 5 | 260
abnormal behavior 4 | 226
embryonic lethality prior to o... 4 | 148
abnormal coat/hair pigmentatio... 3 | 54
decreased bone mineral content 3 | 157
decreased circulating fructosa... 3 | 31
decreased circulating iron lev... 3 | 25
decreased circulating serum al... 3 | 79
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
improved glucose tolerance 3 | 56
increased or absent threshold ... 3 | 128
abnormal embryo size 2 | 112
abnormal lens morphology 2 | 73
abnormal placenta size 2 | 10
abnormal skin coloration 2 | 18
decreased blood urea nitrogen ... 2 | 31
decreased circulating bilirubi... 2 | 14
decreased circulating free fat... 2 | 39
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased hematocrit 2 | 25
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
embryonic growth retardation 2 | 28
hydrops fetalis 2 | 22
hypoactivity 2 | 89
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased circulating iron lev... 2 | 25
increased leukocyte cell numbe... 2 | 37
prenatal lethality prior to he... 2 | 64
abnormal bone structure 1 | 131
abnormal craniofacial morpholo... 1 | 12
abnormal embryo turning 1 | 15
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal locomotor activation 1 | 26
abnormal optic disc morphology 1 | 10
abnormal placenta morphology 1 | 4
abnormal placenta vasculature 1 | 2
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
cataract 1 | 26
decreased NK cell number 1 | 16
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased fasted circulating g... 1 | 49
decreased hemoglobin content 1 | 53
edema 1 | 11
enlarged lymph nodes 1 | 27
hemorrhage 1 | 12
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased B cell number 1 | 23
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 32
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
increased spleen weight 1 | 3
increased total body fat amoun... 1 | 57
long tibia 1 | 13
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
small kidney 1 | 10
small spleen 1 | 11
small testis 1 | 37
stereotypic behavior 1 | 3
tremors 1 | 34
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 161 | 8,484
osteosarcoma 127 | 7,933
psoriasis 127 | 6,685
glioblastoma 124 | 5,572
medulloblastoma, large-cell 123 | 6,234
lung cancer 104 | 4,466
atypical teratoid / rhabdoid tumor 98 | 4,369
Breast cancer 86 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 83 | 3,289
primitive neuroectodermal tumor 77 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 75 | 2,988
non-small cell lung cancer 74 | 2,798
pediatric high grade glioma 71 | 2,712
invasive ductal carcinoma 70 | 2,950
Cancer 69 | 2,346
malignant mesothelioma 66 | 3,162
lung adenocarcinoma 65 | 2,713
pancreatic cancer 57 | 2,300
group 3 medulloblastoma 54 | 2,254
pilocytic astrocytoma 51 | 3,086
Carcinoma 50 | 2,147
adrenocortical carcinoma 48 | 1,427
intraductal papillary-mucinous adenoma (IPMA) 48 | 2,956
breast carcinoma 47 | 1,614
ductal carcinoma in situ 46 | 1,745
subependymal giant cell astrocytoma 44 | 2,287
oligodendroglioma 42 | 2,849
colon cancer 41 | 1,475
posterior fossa group A ependymoma 40 | 1,511
ependymoma 37 | 2,514
lung carcinoma 36 | 2,844
Multiple myeloma 35 | 1,327
Pick disease 33 | 1,893
adult high grade glioma 33 | 2,148
astrocytic glioma 33 | 2,241
Waldenstrons macroglobulinemia 32 | 765
ulcerative colitis 32 | 2,087
interstitial cystitis 31 | 2,299
Endometriosis 30 | 535
IGA Glomerulonephritis 30 | 454
medulloblastoma 30 | 1,524
sonic hedgehog group medulloblastoma 30 | 1,482
primary pancreatic ductal adenocarcinoma 28 | 1,271
dermatomyositis 27 | 933
Atopic dermatitis 26 | 944
astrocytoma 26 | 1,493
cystic fibrosis 26 | 1,665
group 4 medulloblastoma 26 | 1,875
nasopharyngeal carcinoma 25 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
Rheumatoid Arthritis 24 | 1,160
atypical teratoid/rhabdoid tumor 24 | 1,095
juvenile dermatomyositis 24 | 1,189
tuberculosis 24 | 1,557
diabetes mellitus 23 | 1,663
acute quadriplegic myopathy 22 | 1,157
cutaneous lupus erythematosus 22 | 1,056
pituitary cancer 21 | 1,972
primary Sjogren syndrome 20 | 789
spina bifida 17 | 1,064
Mammary Neoplasms 16 | 410
Intellectual disability 14 | 573
hereditary spastic paraplegia 14 | 313
posterior fossa group B ependymoma 14 | 1,530
gastric carcinoma 13 | 832
inflammatory breast cancer 13 | 404
non-small cell lung carcinoma 13 | 413
pancreatic carcinoma 13 | 567
Duchenne muscular dystrophy 12 | 602
Kidney disease 12 | 396
acute myeloid leukemia 12 | 780
Neoplasm Invasiveness 11 | 127
active Crohn's disease 11 | 918
esophageal adenocarcinoma 11 | 737
Liver carcinoma 10 | 217
Prostatic Neoplasms 10 | 471
Schizophrenia 10 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
progressive supranuclear palsy 10 | 674
Alzheimer's disease 9 | 644
Down syndrome 9 | 548
Wiskott-Aldrich syndrome 9 | 27
gastric cancer 9 | 430
tuberculosis and treatment for 6 months 9 | 686
Colorectal Neoplasms 8 | 217
Hypertension 8 | 287
Lissencephaly 8 | 61
Parkinson's disease 8 | 364
Stomach Neoplasms 8 | 282
hepatocellular carcinoma 8 | 532
Bipolar Disorder 7 | 266
Lung Neoplasms 7 | 171
Neoplasm Metastasis 7 | 138
Neurodegenerative disease 7 | 383
Renal Cell Carcinoma 7 | 199
aldosterone-producing adenoma 7 | 664
non primary Sjogren syndrome sicca 7 | 840
ovarian neoplasm 7 | 97
Crohn's disease 6 | 304
Obesity 6 | 616

Tissue

Blood and immune system 248 | 17,995
Digestive Tract 248 | 18,473
Endocrine System 248 | 18,512
Female tissues 248 | 18,647
Male tissues 248 | 17,969
Nervous System 248 | 18,561
Liver and Pancreas 247 | 18,136
Urinary Tract 247 | 18,444
Cardiovascular System 246 | 17,958
Respiratory system 245 | 17,484
Skin and soft tissues 238 | 18,115

Target Family

Non-IDG 178 | 11,971
Enzyme 39 | 4,146
Kinase 26 | 634
Epigenetic 2 | 242
Ion Channel 2 | 341
Nuclear Receptor 1 | 48
Transcription Factor 1 | 1,400

Reactome Pathway

RHO GTPase Effectors 249 | 249
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Wiskott-Aldrich syndrome protein family member 3 WASF3 Tbio Non-IDG -2.43045 280.1 123
Kinetochore protein Nuf2 NUF2 Tbio Non-IDG -1.66072 48.8 98
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56294 358.8 154
Serine/threonine-protein kinase N3 PKN3 Tchem Kinase -1.11681 14.4 104
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
Centromere protein F CENPF Tbio Non-IDG -1.98596 103.0 180
Histone H3-like centromeric protein A CENPA Tbio Non-IDG -2.68837 532.8 347
Protein ELYS AHCTF1 Tbio Non-IDG -1.30356 22.8 57