Development Level

Tbio 155 | 11,651
Tclin 41 | 612
Tchem 34 | 1,388
Tdark 8 | 6,593

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 22 | 979
decreased body weight 8 | 161
abnormal bone structure 7 | 187
abnormal behavior 6 | 298
decreased total body fat amoun... 6 | 207
short tibia 6 | 97
decreased circulating choleste... 5 | 93
embryonic lethality prior to t... 5 | 278
decreased bone mineral content 4 | 151
decreased circulating HDL chol... 4 | 68
hypoactivity 4 | 132
male infertility 4 | 123
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
cataract 3 | 92
decreased circulating LDL chol... 3 | 38
decreased circulating alanine ... 3 | 47
decreased circulating total pr... 3 | 49
decreased heart weight 3 | 27
enlarged heart 3 | 210
female infertility 3 | 60
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased startle reflex 3 | 112
abnormal coat-hair pigmentatio... 2 | 64
abnormal lens morphology 2 | 81
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
decreased caudal vertebrae num... 2 | 53
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased lactate dehydrogenas... 2 | 16
embryonic lethality prior to o... 2 | 239
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
impaired pupillary reflex 2 | 26
increased bone mineral content 2 | 108
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal locomotor behavior 1 | 24
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
corneal opacity 1 | 32
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased exploration in new e... 1 | 11
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased exploration in new e... 1 | 8
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
iris synechia 1 | 3
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 156 | 11,493
ovarian cancer 133 | 8,520
osteosarcoma 123 | 7,950
glioblastoma 104 | 5,792
lung cancer 101 | 4,740
Cancer 99 | 2,499
psoriasis 96 | 6,694
medulloblastoma, large-cell 92 | 6,241
atypical teratoid / rhabdoid tumor 80 | 5,112
Breast cancer 76 | 3,578
ependymoma 73 | 4,679
malignant mesothelioma 67 | 3,232
Kidney cancer 59 | 2,613
adult high grade glioma 59 | 3,801
group 3 medulloblastoma 57 | 4,104
oligodendroglioma 56 | 2,850
Astrocytoma, Pilocytic 53 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,291
astrocytic glioma 52 | 2,597
invasive ductal carcinoma 52 | 2,951
Schizophrenia 49 | 1,160
lung adenocarcinoma 48 | 2,716
Multiple myeloma 47 | 1,332
non-small cell lung cancer 46 | 2,890
interstitial cystitis 45 | 2,312
lung carcinoma 45 | 2,843
subependymal giant cell astrocytoma 45 | 2,287
pancreatic cancer 43 | 2,398
tuberculosis 42 | 2,010
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
primitive neuroectodermal tumor 37 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
ulcerative colitis 35 | 1,819
diabetes mellitus 33 | 1,728
Autosomal recessive predisposition 31 | 1,442
cystic fibrosis 31 | 1,696
pituitary cancer 31 | 1,972
group 4 medulloblastoma 30 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
Rheumatoid arthritis 29 | 1,191
breast carcinoma 29 | 1,638
Bipolar Disorder 28 | 666
Pick disease 28 | 1,894
ductal carcinoma in situ 28 | 1,745
Liver Cirrhosis, Experimental 26 | 769
astrocytoma 26 | 1,146
Intellectual disability 23 | 1,016
Melanoma 23 | 711
colon cancer 23 | 1,478
Depressive disorder 22 | 409
Breast Neoplasms 21 | 445
Epilepsy 21 | 792
Mammary Neoplasms 21 | 425
primary pancreatic ductal adenocarcinoma 21 | 1,109
Downward slant of palpebral fissure 20 | 158
Osteoporosis 19 | 363
Skin cancer 19 | 469
Stomach Neoplasms 19 | 300
Waldenstrons macroglobulinemia 19 | 765
juvenile dermatomyositis 19 | 1,187
Cryptorchidism 18 | 296
Dull intelligence 18 | 645
Low intelligence 18 | 645
Lung Neoplasms 18 | 232
Major Depressive Disorder 18 | 301
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Orbital separation excessive 18 | 244
Parkinson's disease 18 | 392
Poor school performance 18 | 645
Seizures 18 | 596
Short stature 18 | 531
dermatomyositis 18 | 966
Anemia 17 | 365
Cognitive delay 17 | 608
Global developmental delay 17 | 608
HIV Infections 17 | 102
Mental Depression 17 | 333
Mental and motor retardation 17 | 608
Muscle hypotonia 17 | 571
Renal Cell Carcinoma 17 | 214
adrenocortical carcinoma 17 | 1,428
cutaneous lupus erythematosus 17 | 1,057
spina bifida 17 | 1,074
Blepharoptosis 16 | 231
Carcinoma, Hepatocellular 16 | 228
Liver carcinoma 16 | 240
Strabismus 16 | 270
Unipolar Depression 16 | 250
esophageal adenocarcinoma 16 | 737
gastric carcinoma 16 | 807
Alzheimer's disease 15 | 658
Hepatomegaly 15 | 285
Prostatic Neoplasms 15 | 495
non primary Sjogren syndrome sicca 15 | 891
Cleft Palate 14 | 271
Hypoplastic mandible condyle 14 | 275
Mandibular hypoplasia 14 | 275
Micrognathism 14 | 275
Vascular disease 14 | 319

Tissue

Endocrine System 235 | 18,159
Blood and immune system 231 | 16,909
Digestive Tract 231 | 17,369
Female tissues 230 | 17,400
Male tissues 230 | 17,142
Skin and soft tissues 230 | 17,230
Liver and Pancreas 229 | 16,750
Urinary Tract 228 | 16,678
Nervous System 227 | 16,725
Respiratory system 224 | 16,393
Cardiovascular System 214 | 15,192

Target Family

Non-IDG 118 | 12,091
Enzyme 79 | 4,145
Kinase 36 | 634
Ion Channel 5 | 344

Reactome Pathway

RAF/MAP kinase cascade 238 | 238
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Spectrin beta chain, non-erythrocytic 5 SPTBN5 Tbio Non-IDG -0.41365 2.99 32
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
A-kinase anchor protein 9 AKAP9 Tbio Enzyme -2.22554 169.7 142
Kelch repeat and BTB domain-containing protein 7 KBTBD7 Tdark Non-IDG 0.14 0.94 89
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482
WD repeat domain-containing protein 83 WDR83 Tbio Non-IDG -1.17544 17.4 162