Development Level

Tbio 55 | 11,651
Tdark 9 | 6,593
Tchem 1 | 1,388

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased mean corpuscular hem... 3 | 50
preweaning lethality, incomple... 3 | 499
abnormal body wall morphology 2 | 9
abnormal craniofacial morpholo... 2 | 33
abnormal facial morphology 2 | 17
abnormal limb bud morphology 2 | 17
abnormal limb morphology 2 | 13
abnormal sleep behavior 2 | 70
anophthalmia 2 | 33
cleft palate 2 | 8
edema 2 | 59
facial cleft 2 | 3
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
limb grasping 2 | 41
polydactyly 2 | 7
prenatal lethality 2 | 28
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
brachydactyly 1 | 19
cataract 1 | 92
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased large unstained cell... 1 | 11
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased circulating alkaline... 1 | 122
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased circulating thyroxin... 1 | 7
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
syndactyly 1 | 23

Disease

medulloblastoma, large-cell 32 | 6,241
osteosarcoma 30 | 7,950
ovarian cancer 30 | 8,520
glioblastoma 28 | 5,792
atypical teratoid / rhabdoid tumor 26 | 5,112
psoriasis 25 | 6,694
ependymoma 20 | 4,679
lung cancer 20 | 4,740
adult high grade glioma 19 | 3,801
Astrocytoma, Pilocytic 18 | 3,081
Pick disease 18 | 1,894
Carcinoma 17 | 11,493
malignant mesothelioma 17 | 3,232
astrocytic glioma 14 | 2,597
group 3 medulloblastoma 14 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
invasive ductal carcinoma 12 | 2,951
lung carcinoma 12 | 2,843
Griscelli syndrome 11 | 24
Multiple myeloma 11 | 1,332
interstitial cystitis 11 | 2,312
oligodendroglioma 11 | 2,850
pancreatic cancer 11 | 2,398
pituitary cancer 11 | 1,972
subependymal giant cell astrocytoma 11 | 2,287
Breast cancer 10 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 9 | 2,890
primary pancreatic ductal adenocarcinoma 9 | 1,109
primitive neuroectodermal tumor 9 | 3,035
tuberculosis 9 | 2,010
astrocytoma 8 | 1,146
ductal carcinoma in situ 8 | 1,745
gastric carcinoma 8 | 807
lung adenocarcinoma 8 | 2,716
Choroideremia 7 | 16
group 4 medulloblastoma 7 | 1,855
primary Sjogren syndrome 7 | 735
ulcerative colitis 7 | 1,819
Rheumatoid arthritis 6 | 1,191
acute quadriplegic myopathy 6 | 1,158
spina bifida 6 | 1,074
Hermansky-Pudlak syndrome 5 | 42
Liver Cirrhosis, Experimental 5 | 769
Oculocerebrorenal syndrome 5 | 29
Parkinson's disease 5 | 392
adrenocortical carcinoma 5 | 1,428
aldosterone-producing adenoma 5 | 665
cutaneous lupus erythematosus 5 | 1,057
Alzheimer's disease 4 | 658
Cancer 4 | 2,499
Myocardial Ischemia 4 | 169
Warburg micro syndrome 4 | 18
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
sonic hedgehog group medulloblastoma 4 | 467
Autosomal recessive predisposition 3 | 1,442
Epilepsy 3 | 792
Hemophagocytic lymphohistiocytosis 3 | 30
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
esophageal adenocarcinoma 3 | 737
facioscapulohumeral dystrophy 3 | 288
hepatocellular carcinoma 3 | 547
hereditary spastic paraplegia 3 | 318
juvenile dermatomyositis 3 | 1,187
medulloblastoma 3 | 720
non primary Sjogren syndrome sicca 3 | 891
pediatric high grade glioma 3 | 1,064
posterior fossa group A ependymoma 3 | 468
Acquired scoliosis 2 | 281
Amyotrophic lateral sclerosis 2 | 451
Becker muscular dystrophy 2 | 191
Bilateral fifth finger clinodactyly 2 | 110
Brachycephaly 2 | 88
Broad cranium shape 2 | 88
Byzanthine arch palate 2 | 194
Cerebral atrophy 2 | 178
Chronic obstructive pulmonary disease 2 | 184
Curvature of little finger 2 | 110
Curvature of spine 2 | 282
Down syndrome 2 | 499
Duchenne muscular dystrophy 2 | 601
Muscle Spasticity 2 | 195
Neurodegenerative disease 2 | 414
Polycystic ovary syndrome 2 | 360
Seizures 2 | 596
Waldenstrons macroglobulinemia 2 | 765
head and neck cancer 2 | 271
limb girdle muscular dystrophy 2A 2 | 213
mucosa-associated lymphoid tissue lymphoma 2 | 484
nasopharyngeal carcinoma 2 | 1,058
substance-related disorder 2 | 162
tuberculosis and treatment for 3 months 2 | 179

Tissue

Blood and immune system 64 | 16,909
Digestive Tract 64 | 17,369
Endocrine System 64 | 18,159
Female tissues 64 | 17,400
Liver and Pancreas 64 | 16,750
Male tissues 64 | 17,142
Respiratory system 64 | 16,393
Skin and soft tissues 64 | 17,230
Urinary Tract 64 | 16,678
Nervous System 62 | 16,725
Cardiovascular System 58 | 15,192

Target Family

Enzyme 61 | 4,145
Non-IDG 4 | 12,091

Reactome Pathway

RAB geranylgeranylation 65 | 65
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Geranylgeranyl transferase type-2 subunit beta RABGGTB Tbio Enzyme -0.69980 4.51 47
Ras-related protein Rab-40A RAB40A Tdark Non-IDG -0.72564 4.56 104
Ras-related protein Rab-23 RAB23 Tbio Enzyme -1.63391 45.2 211
Ras-related protein Rab-32 RAB32 Tbio Enzyme -1.46660 33.4 127
Ras-related protein Rab-31 RAB31 Tbio Enzyme -1.12978 14.8 109
Ras-related protein Rab-26 RAB26 Tbio Enzyme -0.62141 6.10 119
Ras-related protein Rab-34, isoform NARR RAB34 Tbio Non-IDG -1.77250 102.9 0
Ras-related protein Rab-43 RAB43 Tbio Enzyme -1.58430 37.0 70