Development Level

Tbio 53 | 10,625
Tdark 11 | 7,003
Tchem 2 | 1,890

IMPC Phenotype

preweaning lethality, complete... 7 | 633
abnormal body wall morphology 2 | 7
abnormal craniofacial morpholo... 2 | 12
abnormal facial morphology 2 | 9
abnormal limb bud morphology 2 | 15
abnormal limb morphology 2 | 7
anophthalmia 2 | 20
cleft palate 2 | 6
decreased circulating triglyce... 2 | 83
decreased mean corpuscular hem... 2 | 34
edema 2 | 11
facial cleft 2 | 3
increased circulating alkaline... 2 | 119
increased circulating sodium l... 2 | 71
increased hemoglobin content 2 | 45
limb grasping 2 | 35
polydactyly 2 | 22
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal head morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
corneal opacity 1 | 25
decreased NK T cell number 1 | 28
decreased anxiety-related resp... 1 | 12
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 85
decreased effector memory CD8-... 1 | 24
decreased granulocyte number 1 | 8
decreased grip strength 1 | 123
decreased large unstained cell... 1 | 3
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
decreased mean platelet volume 1 | 12
decreased pre-pro B cell numbe... 1 | 2
decreased rib number 1 | 59
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
hydrometra 1 | 13
impaired pupillary reflex 1 | 14
increased B cell number 1 | 23
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased plasma cell number 1 | 5
increased sacral vertebrae num... 1 | 62
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64

Disease

medulloblastoma, large-cell 33 | 6,234
osteosarcoma 31 | 7,933
ovarian cancer 30 | 8,491
glioblastoma 26 | 5,572
psoriasis 25 | 6,685
atypical teratoid / rhabdoid tumor 23 | 4,369
lung cancer 21 | 4,473
pilocytic astrocytoma 19 | 3,086
Pick disease 18 | 1,893
malignant mesothelioma 17 | 3,163
pediatric high grade glioma 15 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
lung carcinoma 13 | 2,844
astrocytoma 12 | 1,493
ependymoma 12 | 2,514
invasive ductal carcinoma 12 | 2,950
medulloblastoma 12 | 1,524
oligodendroglioma 12 | 2,849
Multiple myeloma 11 | 1,327
astrocytic glioma 11 | 2,241
interstitial cystitis 11 | 2,299
pancreatic cancer 11 | 2,300
pituitary cancer 11 | 1,972
subependymal giant cell astrocytoma 11 | 2,287
Breast cancer 10 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
primitive neuroectodermal tumor 10 | 3,031
non-small cell lung cancer 9 | 2,798
primary pancreatic ductal adenocarcinoma 9 | 1,271
ulcerative colitis 9 | 2,087
Choroideremia 8 | 13
adult high grade glioma 8 | 2,148
ductal carcinoma in situ 8 | 1,745
gastric carcinoma 8 | 832
lung adenocarcinoma 8 | 2,714
posterior fossa group A ependymoma 7 | 1,511
primary Sjogren syndrome 7 | 788
Hermansky-Pudlak syndrome 6 | 43
Rheumatoid Arthritis 6 | 1,170
acute quadriplegic myopathy 6 | 1,157
group 3 medulloblastoma 6 | 2,254
sonic hedgehog group medulloblastoma 6 | 1,482
spina bifida 6 | 1,064
Oculocerebrorenal syndrome 5 | 24
Parkinson's disease 5 | 364
adrenocortical carcinoma 5 | 1,427
aldosterone-producing adenoma 5 | 664
cutaneous lupus erythematosus 5 | 1,056
group 4 medulloblastoma 5 | 1,875
posterior fossa group B ependymoma 5 | 1,530
tuberculosis 5 | 1,563
tuberculosis and treatment for 3 months 5 | 327
Alzheimer's disease 4 | 644
Cancer 4 | 2,346
Myocardial Ischemia 4 | 169
Warburg micro syndrome 4 | 19
atypical teratoid/rhabdoid tumor 4 | 1,095
breast carcinoma 4 | 1,614
colon cancer 4 | 1,475
cystic fibrosis 4 | 1,670
dermatomyositis 4 | 966
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Gaucher disease type 1 3 | 171
Hemophagocytic lymphohistiocytosis 3 | 30
IGA Glomerulonephritis 3 | 454
active Crohn's disease 3 | 918
acute myeloid leukemia 3 | 785
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
esophageal adenocarcinoma 3 | 737
facioscapulohumeral dystrophy 3 | 286
glioblastoma multiforme 3 | 347
hepatocellular carcinoma 3 | 550
hereditary spastic paraplegia 3 | 313
juvenile dermatomyositis 3 | 1,189
non primary Sjogren syndrome sicca 3 | 840
ARC syndrome 2 | 14
Becker muscular dystrophy 2 | 187
Cervical cancer 2 | 23
Chronic obstructive pulmonary disease 2 | 147
Down syndrome 2 | 548
Duchenne muscular dystrophy 2 | 602
HIV Infections 2 | 99
Legionnaires' disease 2 | 20
Low compliance bladder 2 | 11
Neurodegenerative disease 2 | 383
Oculocutaneous albinism 2 | 28
Platelet storage pool deficiency 2 | 21
Polycystic Ovary Syndrome 2 | 334
Rectum cancer 2 | 12
Waldenstrons macroglobulinemia 2 | 764
gastric cancer 2 | 436
head and neck cancer 2 | 270
head and neck cancer and chronic obstructive pulmonary disease 2 | 237
limb girdle muscular dystrophy 2A 2 | 156
mucosa-associated lymphoid tissue lymphoma 2 | 480
nasopharyngeal carcinoma 2 | 1,056
substance-related disorder 2 | 104
tuberculosis and treatment for 6 months 2 | 686
Epilepsy 1 | 346

Tissue

Digestive Tract 66 | 18,472
Nervous System 66 | 18,560
Urinary Tract 66 | 18,443
Blood and immune system 65 | 17,994
Cardiovascular System 65 | 17,957
Endocrine System 65 | 18,511
Female tissues 65 | 18,646
Liver and Pancreas 65 | 18,135
Male tissues 65 | 17,968
Respiratory system 65 | 17,483
Skin and soft tissues 64 | 18,114

Target Family

Enzyme 62 | 4,146
Non-IDG 4 | 11,969

Reactome Pathway

RAB geranylgeranylation 66 | 66
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-34, isoform NARR RAB34 Tdark Non-IDG -1.72269 96.1 0
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.62399 398.9 288
Ras-related protein Rab-9A RAB9A Tchem Enzyme -0.85278 7.48 172
Ras-related protein Rab-13 RAB13 Tbio Enzyme -1.38773 26.2 55
Ras-related protein Rab-27A RAB27A Tbio Enzyme -2.26523 184.9 247
Ras-related protein Rab-43 RAB43 Tbio Enzyme -1.56568 35.9 63
Ras-related protein Rab-5C RAB5C Tbio Enzyme -1.13690 11.1 135
Ras-related protein Rab-7a RAB7A Tbio Enzyme -2.63101 403.7 216
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.43730 28.2 91
Ras-related protein Rab-26 RAB26 Tbio Enzyme -0.55617 5.20 111