Development Level

Tbio 34 | 10,625
Tchem 12 | 1,890
Tclin 1 | 602
Tdark 1 | 7,003

IMPC Phenotype

preweaning lethality, complete... 5 | 633
decreased circulating HDL chol... 2 | 77
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal kidney morphology 1 | 30
abnormal testis morphology 1 | 30
decreased IgM level 1 | 1
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased lactate dehydrogenas... 1 | 14
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased lean body mass 1 | 107
small testis 1 | 37

Disease

ovarian cancer 33 | 8,491
osteosarcoma 24 | 7,933
medulloblastoma, large-cell 21 | 6,234
psoriasis 18 | 6,685
Multiple myeloma 15 | 1,327
lung cancer 15 | 4,473
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
glioblastoma 14 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
atypical teratoid / rhabdoid tumor 11 | 4,369
invasive ductal carcinoma 11 | 2,950
Cancer 10 | 2,346
astrocytic glioma 10 | 2,241
non-small cell lung cancer 10 | 2,798
ulcerative colitis 10 | 2,087
Breast cancer 9 | 3,098
Pick disease 9 | 1,893
ependymoma 9 | 2,514
lung adenocarcinoma 9 | 2,714
Leigh disease 8 | 81
malignant mesothelioma 8 | 3,163
adult high grade glioma 7 | 2,148
colon cancer 7 | 1,475
group 4 medulloblastoma 7 | 1,875
medulloblastoma 7 | 1,524
pancreatic cancer 7 | 2,300
Lactic acidosis 6 | 43
dermatomyositis 6 | 966
ductal carcinoma in situ 6 | 1,745
hereditary spastic paraplegia 6 | 313
oligodendroglioma 6 | 2,849
Neoplastic Syndromes, Hereditary 5 | 48
Obesity 5 | 616
Pyruvate decarboxylase deficiency 5 | 15
acute quadriplegic myopathy 5 | 1,157
gastric carcinoma 5 | 832
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
non primary Sjogren syndrome sicca 5 | 840
pilocytic astrocytoma 5 | 3,086
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,271
primitive neuroectodermal tumor 5 | 3,031
Cardiomyopathies 4 | 90
D-2-hydroxyglutaric aciduria 4 | 9
Degenerative polyarthritis 4 | 93
Down syndrome 4 | 548
Endometriosis 4 | 535
Gastrointestinal stromal tumor 4 | 61
Hemangioma 4 | 35
Persistent generalized lymphadenopathy 4 | 15
Phaeochromocytoma 4 | 20
active Crohn's disease 4 | 918
adrenocortical carcinoma 4 | 1,427
astrocytoma 4 | 1,493
breast carcinoma 4 | 1,614
group 3 medulloblastoma 4 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
juvenile dermatomyositis 4 | 1,189
lung carcinoma 4 | 2,844
pancreatic carcinoma 4 | 567
posterior fossa group A ependymoma 4 | 1,511
2-hydroxyglutaric aciduria 3 | 5
Atopic dermatitis 3 | 944
Carney Triad 3 | 3
Chondroma 3 | 12
Combined D-2- and L-2-hydroxyglutaric aciduria 3 | 4
Cowden disease 3 | 20
Disease Progression 3 | 125
Gastrointestinal Stromal Tumors 3 | 8
Hamartoma Syndrome, Multiple 3 | 9
Methylmalonic acidemia 3 | 39
Mitochondrial complex II deficiency 3 | 5
Myocardial Infarction 3 | 126
Myocardial Ischemia 3 | 169
Neurofibromatosis 3 | 37
Paraganglioma 3 | 12
Paraganglioma and gastric stromal sarcoma 3 | 3
Prostatic Neoplasms 3 | 471
Renal Cell Carcinoma 3 | 199
Stomach Neoplasms 3 | 282
Waldenstrons macroglobulinemia 3 | 764
atypical teratoid/rhabdoid tumor 3 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
diabetes mellitus 3 | 1,663
extra-adrenal pheochromocytoma 3 | 7
glioblastoma multiforme 3 | 347
interstitial cystitis 3 | 2,299
mucosa-associated lymphoid tissue lymphoma 3 | 480
pediatric high grade glioma 3 | 2,712
Duchenne muscular dystrophy 2 | 602
IGA Glomerulonephritis 2 | 454
Neurodegenerative disease 2 | 383
Peripheral Neuropathy 2 | 303
aldosterone-producing adenoma 2 | 664
cutaneous lupus erythematosus 2 | 1,056
inflammatory breast cancer 2 | 404
sonic hedgehog group medulloblastoma 2 | 1,482
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,563
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 48 | 17,994
Cardiovascular System 48 | 17,957
Digestive Tract 48 | 18,472
Endocrine System 48 | 18,511
Female tissues 48 | 18,646
Liver and Pancreas 48 | 18,135
Male tissues 48 | 17,968
Nervous System 48 | 18,560
Respiratory system 48 | 17,483
Skin and soft tissues 48 | 18,114
Urinary Tract 48 | 18,443

Target Family

Enzyme 36 | 4,146
Kinase 4 | 634
Non-IDG 3 | 11,969
Transporter 3 | 473
Nuclear Receptor 2 | 48

Reactome Pathway

Pyruvate metabolism and Citric... 48 | 48
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Monocarboxylate transporter 1 SLC16A1 Tchem Transporter -2.42636 263.7 235
L-lactate dehydrogenase A-like 6A LDHAL6A Tdark Enzyme -0.31243 2.01 90
Retinoic acid receptor RXR-alpha RXRA Tclin Nuclear Receptor -2.47322 228.6 266
Fumarate hydratase, mitochondrial FH Tbio Enzyme -2.38028 230.7 307
L-lactate dehydrogenase C chain LDHC Tbio Enzyme -2.70941 505.5 151
Basigin BSG Tchem Non-IDG -3.03729 1224.4 997
Citrate synthase, mitochondrial CS Tbio Enzyme -2.59718 316.0 182
Isocitrate dehydrogenase [NADP], mitochondrial IDH2 Tbio Enzyme -2.87026 700.9 270
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial DLST Tbio Enzyme -1.75775 38.4 112
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB Tbio Enzyme -1.68544 44.6 137