Development Level

Tbio 34 | 10,625
Tchem 12 | 1,890
Tclin 1 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 5 | 633
decreased circulating HDL chol... 2 | 77
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal kidney morphology 1 | 30
abnormal testis morphology 1 | 30
decreased IgM level 1 | 1
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased lactate dehydrogenas... 1 | 14
embryonic lethality prior to t... 1 | 187
increased bone mineral content 1 | 92
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased lean body mass 1 | 107
small testis 1 | 37

Disease

ovarian cancer 33 | 8,484
osteosarcoma 24 | 7,933
medulloblastoma, large-cell 21 | 6,234
psoriasis 18 | 6,685
Multiple myeloma 15 | 1,327
lung cancer 15 | 4,466
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
glioblastoma 14 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
atypical teratoid / rhabdoid tumor 11 | 4,369
invasive ductal carcinoma 11 | 2,950
Cancer 10 | 2,346
astrocytic glioma 10 | 2,241
non-small cell lung cancer 10 | 2,798
ulcerative colitis 10 | 2,087
Breast cancer 9 | 3,094
Pick disease 9 | 1,893
ependymoma 9 | 2,514
lung adenocarcinoma 9 | 2,713
Leigh disease 8 | 81
malignant mesothelioma 8 | 3,162
adult high grade glioma 7 | 2,148
colon cancer 7 | 1,475
group 4 medulloblastoma 7 | 1,875
medulloblastoma 7 | 1,524
pancreatic cancer 7 | 2,300
Lactic acidosis 6 | 42
dermatomyositis 6 | 933
ductal carcinoma in situ 6 | 1,745
hereditary spastic paraplegia 6 | 313
oligodendroglioma 6 | 2,849
Neoplastic Syndromes, Hereditary 5 | 48
Obesity 5 | 616
Pyruvate decarboxylase deficiency 5 | 15
acute quadriplegic myopathy 5 | 1,157
gastric carcinoma 5 | 832
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
non primary Sjogren syndrome sicca 5 | 840
pilocytic astrocytoma 5 | 3,086
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,271
primitive neuroectodermal tumor 5 | 3,031
Cardiomyopathies 4 | 90
D-2-hydroxyglutaric aciduria 4 | 9
Degenerative polyarthritis 4 | 93
Down syndrome 4 | 548
Endometriosis 4 | 535
Gastrointestinal stromal tumor 4 | 61
Hemangioma 4 | 35
Persistent generalized lymphadenopathy 4 | 15
Phaeochromocytoma 4 | 20
active Crohn's disease 4 | 918
adrenocortical carcinoma 4 | 1,427
astrocytoma 4 | 1,493
breast carcinoma 4 | 1,614
group 3 medulloblastoma 4 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
juvenile dermatomyositis 4 | 1,189
lung carcinoma 4 | 2,844
pancreatic carcinoma 4 | 567
posterior fossa group A ependymoma 4 | 1,511
2-hydroxyglutaric aciduria 3 | 5
Atopic dermatitis 3 | 944
Carney Triad 3 | 3
Chondroma 3 | 12
Combined D-2- and L-2-hydroxyglutaric aciduria 3 | 4
Disease Progression 3 | 125
Gastrointestinal Stromal Tumors 3 | 8
Hamartoma Syndrome, Multiple 3 | 9
Methylmalonic acidemia 3 | 39
Mitochondrial complex II deficiency 3 | 5
Myocardial Infarction 3 | 126
Myocardial Ischemia 3 | 169
Neurofibromatosis 3 | 37
PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA 3 | 3
Paraganglioma 3 | 12
Prostatic Neoplasms 3 | 471
Renal Cell Carcinoma 3 | 199
Stomach Neoplasms 3 | 282
Waldenstrons macroglobulinemia 3 | 765
atypical teratoid/rhabdoid tumor 3 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
diabetes mellitus 3 | 1,663
extra-adrenal pheochromocytoma 3 | 7
glioblastoma multiforme 3 | 347
interstitial cystitis 3 | 2,299
mucosa-associated lymphoid tissue lymphoma 3 | 480
pediatric high grade glioma 3 | 2,712
Duchenne muscular dystrophy 2 | 602
IGA Glomerulonephritis 2 | 454
Neurodegenerative disease 2 | 383
Peripheral Neuropathy 2 | 303
aldosterone-producing adenoma 2 | 664
cutaneous lupus erythematosus 2 | 1,056
cystic fibrosis and chronic rhinosinusitis 2 | 213
inflammatory breast cancer 2 | 404
sonic hedgehog group medulloblastoma 2 | 1,482
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,557
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 48 | 17,995
Cardiovascular System 48 | 17,958
Digestive Tract 48 | 18,473
Endocrine System 48 | 18,512
Female tissues 48 | 18,647
Liver and Pancreas 48 | 18,136
Male tissues 48 | 17,969
Nervous System 48 | 18,561
Respiratory system 48 | 17,484
Skin and soft tissues 48 | 18,115
Urinary Tract 48 | 18,444

Target Family

Enzyme 36 | 4,146
Kinase 4 | 634
Non-IDG 3 | 11,971
Transporter 3 | 473
Nuclear Receptor 2 | 48

Reactome Pathway

Pyruvate metabolism and Citric... 48 | 48
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
L-lactate dehydrogenase A chain LDHA Tchem Enzyme -2.99664 983.0 487
Monocarboxylate transporter 4 SLC16A3 Tchem Transporter -1.28824 17.3 145
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial PDPR Tbio Enzyme -1.14194 15.5 46
Hydroxyacid-oxoacid transhydrogenase, mitochondrial ADHFE1 Tchem Enzyme -1.31482 23.4 62
Monocarboxylate transporter 3 SLC16A8 Tbio Transporter -1.49770 31.5 85
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G Tbio Enzyme -0.19018 0.67 161
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A Tbio Enzyme -1.40593 22.4 131
L-lactate dehydrogenase A-like 6B LDHAL6B Tbio Enzyme -1.69820 49.9 87