Development Level

Tbio 64 | 10,625
Tchem 16 | 1,890
Tdark 13 | 7,003
Tclin 8 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 4 | 633
preweaning lethality, incomple... 4 | 260
abnormal behavior 2 | 226
abnormal spleen morphology 2 | 36
impaired righting response 2 | 19
abnormal lumbar vertebrae morp... 1 | 6
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent lymph nodes 1 | 3
absent spleen 1 | 1
anophthalmia 1 | 20
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased bone mineral content 1 | 157
decreased cardiac muscle contr... 1 | 5
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
enlarged spleen 1 | 26
hyperactivity 1 | 108
increased CD4-positive, alpha ... 1 | 15
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased exploration in new e... 1 | 56
increased mean corpuscular hem... 1 | 93
increased total body fat amoun... 1 | 57
prenatal lethality prior to he... 1 | 64
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

ovarian cancer 55 | 8,484
medulloblastoma, large-cell 41 | 6,234
osteosarcoma 41 | 7,933
glioblastoma 38 | 5,572
psoriasis 36 | 6,685
lung cancer 29 | 4,466
atypical teratoid / rhabdoid tumor 26 | 4,369
Breast cancer 22 | 3,094
primitive neuroectodermal tumor 22 | 3,031
pilocytic astrocytoma 21 | 3,086
non-small cell lung cancer 20 | 2,798
Multiple myeloma 19 | 1,327
ependymoma 19 | 2,514
pediatric high grade glioma 18 | 2,712
group 3 medulloblastoma 16 | 2,254
malignant mesothelioma 16 | 3,162
oligodendroglioma 16 | 2,849
astrocytic glioma 15 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
invasive ductal carcinoma 15 | 2,950
lung carcinoma 15 | 2,844
pancreatic cancer 15 | 2,300
subependymal giant cell astrocytoma 15 | 2,287
breast carcinoma 14 | 1,614
colon cancer 14 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
lung adenocarcinoma 13 | 2,713
ulcerative colitis 13 | 2,087
Pick disease 12 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
Cancer 11 | 2,346
astrocytoma 11 | 1,493
diabetes mellitus 11 | 1,663
posterior fossa group A ependymoma 11 | 1,511
sonic hedgehog group medulloblastoma 11 | 1,482
Rheumatoid Arthritis 10 | 1,160
adult high grade glioma 10 | 2,148
dermatomyositis 10 | 933
Waldenstrons macroglobulinemia 9 | 765
group 4 medulloblastoma 9 | 1,875
juvenile dermatomyositis 9 | 1,189
primary pancreatic ductal adenocarcinoma 9 | 1,271
Duchenne muscular dystrophy 8 | 602
active Crohn's disease 8 | 918
acute quadriplegic myopathy 8 | 1,157
interstitial cystitis 8 | 2,299
nasopharyngeal carcinoma 8 | 1,056
Acute lymphoid leukemia 7 | 25
Anaplastic large T-cell systemic malignant lymphoma 7 | 10
Burkitt's lymphoma 7 | 15
Carcinoma of breast 7 | 11
Carcinoma of female breast 7 | 20
Diffuse non-Hodgkin's lymphoma, large cell 7 | 12
Follicular non-Hodgkin's lymphoma 7 | 17
Gestational trophoblastic neoplasia 7 | 14
HER2-positive carcinoma of breast 7 | 10
Hodgkin's disease 7 | 18
Hypertensive disorder 7 | 58
Kaposi's sarcoma 7 | 20
Langerhans cell histiocytosis, disseminated 7 | 10
Liposarcoma 7 | 20
Malignant tumor of head and/or neck 7 | 15
Malignant tumor of ovary 7 | 25
Malignant tumor of prostate 7 | 11
Malignant tumor of stomach 7 | 12
Malignant tumor of testis 7 | 11
Mammary Neoplasms 7 | 410
Metastatic Breast Carcinoma 7 | 21
Metastatic Prostate Carcinoma 7 | 18
Mycosis fungoides 7 | 28
Nephroblastoma 7 | 45
Neuroblastoma 7 | 78
Non-Hodgkin's lymphoma 7 | 22
Ocular hypertension 7 | 27
Open-angle glaucoma 7 | 26
Rhabdomyosarcoma 7 | 29
Secondary malignant neoplasm of pancreas 7 | 10
Transitional cell carcinoma 7 | 18
atypical teratoid/rhabdoid tumor 7 | 1,095
ductal carcinoma in situ 7 | 1,745
medulloblastoma 7 | 1,524
pituitary cancer 7 | 1,972
posterior fossa group B ependymoma 7 | 1,530
tuberculosis 7 | 1,557
Condyloma acuminatum 6 | 7
Intellectual disability 6 | 573
Lissencephaly 6 | 61
Neurodegenerative disease 6 | 383
cystic fibrosis 6 | 1,665
hypoparathyroidism-retardation-dysmorphism syndrome 6 | 7
Amyotrophic Lateral Sclerosis 5 | 431
Microcephaly 5 | 149
Squamous cell carcinoma 5 | 94
Stomach Neoplasms 5 | 282
adrenocortical carcinoma 5 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
pancreatic carcinoma 5 | 567
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Obesity 4 | 616
cutaneous lupus erythematosus 4 | 1,056

Tissue

Blood and immune system 101 | 17,995
Digestive Tract 101 | 18,473
Endocrine System 101 | 18,512
Female tissues 101 | 18,647
Liver and Pancreas 101 | 18,136
Male tissues 101 | 17,969
Nervous System 101 | 18,561
Skin and soft tissues 101 | 18,115
Urinary Tract 101 | 18,444
Cardiovascular System 100 | 17,958
Respiratory system 99 | 17,484

Target Family

Non-IDG 85 | 11,971
Enzyme 9 | 4,146
Kinase 4 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Protein folding 101 | 101
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 11 USP11 Tbio Enzyme -1.06624 14.9 210
Kinesin-like protein KIFC3 KIFC3 Tchem Non-IDG -1.08696 12.5 48
Tubulin beta-2A chain TUBB2A Tclin Non-IDG -1.58651 36.1 215
T-complex protein 1 subunit delta CCT4 Tbio Non-IDG -1.76354 56.6 151
F-box/WD repeat-containing protein 10 FBXW10 Tdark Non-IDG -0.81410 6.42 42
T-complex protein 1 subunit theta CCT8 Tbio Non-IDG -1.45966 29.4 180
T-complex protein 1 subunit epsilon CCT5 Tbio Non-IDG -1.39059 24.5 183
Regulator of G-protein signaling 7 RGS7 Tbio Non-IDG -1.66114 49.5 132
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 GNB2 Tbio Non-IDG -0.43889 2.98 102
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 Tbio Non-IDG -1.15715 18.1 144