Development Level

Tbio 70 | 11,445
Tchem 13 | 1,598
Tdark 9 | 6,588
Tclin 8 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 5 | 499
abnormal behavior 2 | 298
abnormal spleen morphology 2 | 55
decreased circulating aspartat... 2 | 34
enlarged spleen 2 | 41
impaired righting response 2 | 26
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal lens morphology 1 | 81
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent lymph nodes 1 | 3
absent spleen 1 | 3
anophthalmia 1 | 33
cataract 1 | 92
decreased basophil cell number 1 | 16
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased red blood cell distr... 1 | 34
prenatal lethality prior to he... 1 | 87
small kidney 1 | 16
small superior vagus ganglion 1 | 74

Disease

Carcinoma 60 | 11,493
ovarian cancer 54 | 8,520
medulloblastoma, large-cell 40 | 6,241
osteosarcoma 40 | 7,950
glioblastoma 39 | 5,792
psoriasis 36 | 6,694
ependymoma 34 | 4,679
atypical teratoid / rhabdoid tumor 30 | 5,112
lung cancer 30 | 4,740
group 3 medulloblastoma 28 | 4,104
Breast cancer 27 | 3,578
primitive neuroectodermal tumor 21 | 3,035
Astrocytoma, Pilocytic 20 | 3,081
astrocytic glioma 20 | 2,597
non-small cell lung cancer 20 | 2,890
Multiple myeloma 19 | 1,332
adult high grade glioma 19 | 3,801
malignant mesothelioma 16 | 3,232
oligodendroglioma 16 | 2,850
breast carcinoma 15 | 1,638
invasive ductal carcinoma 15 | 2,951
lung carcinoma 15 | 2,843
pancreatic cancer 15 | 2,398
subependymal giant cell astrocytoma 15 | 2,287
colon cancer 14 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Pick disease 12 | 1,894
diabetes mellitus 12 | 1,728
lung adenocarcinoma 12 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
ulcerative colitis 11 | 1,819
Autosomal recessive predisposition 10 | 1,442
Cancer 10 | 2,499
Rheumatoid arthritis 9 | 1,191
Waldenstrons macroglobulinemia 9 | 765
dermatomyositis 9 | 966
juvenile dermatomyositis 9 | 1,187
Duchenne muscular dystrophy 8 | 601
Epilepsy 8 | 792
Intellectual disability 8 | 1,016
Liposarcoma 8 | 20
Nephroblastoma 8 | 51
Seizures 8 | 596
active Crohn's disease 8 | 922
acute quadriplegic myopathy 8 | 1,158
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
nasopharyngeal carcinoma 8 | 1,058
pediatric high grade glioma 8 | 1,064
primary pancreatic ductal adenocarcinoma 8 | 1,109
tuberculosis 8 | 2,010
Acute lymphoid leukemia 7 | 25
Anaplastic large T-cell systemic malignant lymphoma 7 | 10
Breast Neoplasms 7 | 445
Burkitt's lymphoma 7 | 15
Carcinoma of breast 7 | 11
Carcinoma of female breast 7 | 20
Cognitive delay 7 | 608
Diffuse non-Hodgkin's lymphoma, large cell 7 | 12
Follicular non-Hodgkin's lymphoma 7 | 17
Gestational trophoblastic neoplasia 7 | 14
Global developmental delay 7 | 608
HER2-positive carcinoma of breast 7 | 21
Hodgkin's disease 7 | 18
Hypertensive disorder 7 | 56
Kaposi's sarcoma 7 | 22
Langerhans cell histiocytosis, disseminated 7 | 10
Malignant tumor of head and/or neck 7 | 15
Malignant tumor of ovary 7 | 25
Malignant tumor of prostate 7 | 26
Malignant tumor of stomach 7 | 12
Malignant tumor of testis 7 | 11
Mammary Neoplasms 7 | 425
Mental and motor retardation 7 | 608
Metastatic Breast Carcinoma 7 | 21
Metastatic Prostate Carcinoma 7 | 18
Mycosis fungoides 7 | 29
Neuroblastoma 7 | 80
Neurodegenerative disease 7 | 414
Non-Hodgkin's lymphoma 7 | 22
Ocular hypertension 7 | 42
Open-angle glaucoma 7 | 27
Rhabdomyosarcoma 7 | 39
Schizophrenia 7 | 1,160
Secondary malignant neoplasm of pancreas 7 | 10
ductal carcinoma in situ 7 | 1,745
pituitary cancer 7 | 1,972
transitional cell carcinoma 7 | 22
Condyloma acuminatum 6 | 7
Kidney cancer 6 | 2,613
Lissencephaly 6 | 69
Small head 6 | 374
Squamous cell carcinoma 6 | 129
cystic fibrosis 6 | 1,696
hypoparathyroidism-retardation-dysmorphism syndrome 6 | 7
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962

Tissue

Endocrine System 100 | 18,159
Digestive Tract 99 | 17,369
Skin and soft tissues 98 | 17,230
Female tissues 97 | 17,400
Male tissues 97 | 17,142
Nervous System 97 | 16,725
Blood and immune system 96 | 16,909
Urinary Tract 95 | 16,678
Liver and Pancreas 94 | 16,750
Respiratory system 94 | 16,393
Cardiovascular System 92 | 15,192

Target Family

Non-IDG 84 | 12,091
Enzyme 9 | 4,145
Kinase 4 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Protein folding 100 | 100
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 GNG10 Tdark Non-IDG 0.16 0.62 18
T-complex protein 1 subunit alpha TCP1 Tbio Non-IDG -2.26984 173.7 468
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Tubulin-specific chaperone D TBCD Tbio Non-IDG -1.71996 50.5 50
Tubulin alpha-8 chain TUBA8 Tbio Non-IDG -0.87821 7.61 118
Tubulin beta-6 chain TUBB6 Tclin Non-IDG -0.94163 8.01 85
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 ARFGEF2 Tbio Non-IDG -1.15371 14.4 81
Lon protease homolog 2, peroxisomal LONP2 Tbio Enzyme -1.00177 8.20 100