Development Level

Tbio 4 | 11,445

IMPC Phenotype

embryonic lethality prior to t... 1 | 278
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 4 | 11,493
Propionic acidemia 4 | 16
ovarian cancer 4 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Autosomal recessive predisposition 3 | 1,442
Cardiomyopathies 3 | 110
Cognitive delay 3 | 608
Comatose 3 | 56
Decreased platelet count 3 | 111
Dehydration 3 | 40
Dull intelligence 3 | 645
Dystonia 3 | 164
Dystonic disease 3 | 106
Failure to gain weight 3 | 365
Global developmental delay 3 | 608
Hepatomegaly 3 | 285
Hyperammonemia 3 | 30
Hyperglycinemia 3 | 6
Intellectual disability 3 | 1,016
Lethargy 3 | 77
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Metabolic acidosis 3 | 90
Methylmalonic acidemia 3 | 37
Pancreatitis 3 | 123
Pediatric failure to thrive 3 | 365
Poor school performance 3 | 645
Thrombocytopenia 3 | 197
Vomiting 3 | 116
lung cancer 3 | 4,740
Abnormality of immune system physiology 2 | 16
Acidosis, Lactic 2 | 97
Acute encephalopathy 2 | 4
Anemia 2 | 365
Apnea 2 | 45
Axial hypotonia 2 | 46
Cardiac Arrhythmia 2 | 103
Cardiac conduction abnormalities 2 | 78
Cerebral atrophy 2 | 178
Conduction disorder of the heart 2 | 79
Constipation 2 | 181
Decrease in appetite 2 | 8
Degenerative brain disorder 2 | 100
Dyschezia 2 | 135
EKG abnormalities 2 | 78
Eczema 2 | 45
Electrocardiogram abnormal 2 | 81
Electrocardiogram change 2 | 78
Epilepsy 2 | 792
Feeding difficulties in infancy 2 | 175
Glycinuria 2 | 10
HYPERGLYCINURIA (disorder) 2 | 12
Hemoglobin low 2 | 124
Homocystinuria 2 | 21
Hypoglycemia 2 | 152
Lactic acidemia 2 | 95
Limb hypertonia 2 | 5
Neutrophil count decreased 2 | 47
Organic aciduria 2 | 6
Osteoporosis 2 | 363
Pancytopenia 2 | 45
Propionic acidemia, type II 2 | 2
Seizures 2 | 596
Short stature 2 | 531
Supratentorial atrophy 2 | 94
Tachypnea 2 | 20
Vitamin B12 deficiency 2 | 20
glioblastoma 2 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
medulloblastoma, large-cell 2 | 6,241
non primary Sjogren syndrome sicca 2 | 891
osteosarcoma 2 | 7,950
3-Methylcrotonyl-CoA carboxylase deficiency 1 | 11
Atherosclerosis 1 | 291
Breast cancer 1 | 3,578
Disease of metabolism 1 | 18
Dysarthria 1 | 192
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Isovaleric acidemia 1 | 15
Kidney cancer 1 | 2,613
Leukopenia 1 | 72
Liver cancer 1 | 604
Nausea and vomiting 1 | 97
Poor growth 1 | 114
Refractive error 1 | 50
Respiratory distress 1 | 43
Very poor growth 1 | 114
adrenocortical carcinoma 1 | 1,428
cystic fibrosis 1 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
lung adenocarcinoma 1 | 2,716
non-small cell lung cancer 1 | 2,890
psoriasis 1 | 6,694
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 2,010
ulcerative colitis 1 | 1,819

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Enzyme 3 | 4,145
Non-IDG 1 | 12,091

Reactome Pathway

Propionyl-CoA catabolism 4 | 4
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylmalonic aciduria type A protein, mitochondrial MMAA Tbio Non-IDG -2.22747 160.8 90
Methylmalonyl-CoA mutase, mitochondrial MUT Tbio Enzyme -2.51690 305.3 99
Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA Tbio Enzyme -2.12940 126.6 118
Propionyl-CoA carboxylase beta chain, mitochondrial PCCB Tbio Enzyme -1.77648 58.9 136