Development Level

Tbio 5 | 11,445
Tchem 4 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased threshold for audito... 1 | 26
embryonic lethality prior to t... 1 | 278

Disease

Cancer 8 | 2,499
Carcinoma 7 | 11,493
osteosarcoma 6 | 7,950
ependymoma 5 | 4,679
medulloblastoma, large-cell 5 | 6,241
ovarian cancer 5 | 8,520
Intellectual disability 4 | 1,016
astrocytic glioma 4 | 2,597
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
psoriasis 4 | 6,694
Parkinson's disease 3 | 392
adult high grade glioma 3 | 3,801
group 4 medulloblastoma 3 | 1,855
juvenile dermatomyositis 3 | 1,187
lung cancer 3 | 4,740
oligodendroglioma 3 | 2,850
Absence of pain sensation 2 | 5
Acral ulceration and osteomyelitis leading to autoamputation 2 | 4
Alzheimer's disease 2 | 658
Anhidrosis 2 | 23
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Bowed and upward slanting eyebrows 2 | 41
Breast cancer 2 | 3,578
Cognitive delay 2 | 608
Congenital Pain Insensitivity 2 | 6
Corneal Ulcer 2 | 21
Dull intelligence 2 | 645
Global developmental delay 2 | 608
Hereditary Sensory Autonomic Neuropathy, Type 5 2 | 5
Hereditary Sensory and Autonomic Neuropathies 2 | 4
Hyperactive behavior 2 | 91
Infantile onset 2 | 238
Lewy Body Disease 2 | 21
Low intelligence 2 | 645
Lung Injury 2 | 20
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Poor school performance 2 | 645
Schizophrenia 2 | 1,160
Self Mutilation 2 | 14
Short stature 2 | 531
Skin Ulcer 2 | 48
Small head 2 | 374
Thick, flared eyebrows 2 | 41
Toxic encephalopathy 2 | 141
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
hereditary spastic paraplegia 2 | 318
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
non primary Sjogren syndrome sicca 2 | 891
Abnormality of earlobe 1 | 5
Acquired flat foot 1 | 72
Anal fistula 1 | 6
Cloudy cornea 1 | 33
Congenital hemivertebra 1 | 25
Corneal stromal opacities 1 | 33
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
DiGeorge syndrome 1 | 47
Esophageal atresia 1 | 43
Flatfoot 1 | 73
Glomerulonephritis 1 | 46
HSAN Type IV 1 | 1
Hemangiosarcoma 1 | 18
Hemolytic-Uremic Syndrome 1 | 30
Hereditary spherocytosis type 1 1 | 23
Hyperkinesis 1 | 32
Imperforate anus 1 | 25
Infarction, Middle Cerebral Artery 1 | 33
Irritation - emotion 1 | 68
Kidney Failure, Chronic 1 | 46
Lymphoma, T-Cell, Cutaneous 1 | 22
Microdontia (disorder) 1 | 59
Neurogenic arthropathy 1 | 2
Neurogenic bladder 1 | 16
Neurogenic bowel 1 | 6
Papillary thyroid carcinoma 1 | 43
Parkinsonian Disorders 1 | 56
Peripheral Neuropathy 1 | 134
Phaeochromocytoma 1 | 20
Rectal prolapse 1 | 19
Rhabdomyosarcoma 1 | 39
Sarcoma 1 | 62
Self-Injurious Behavior 1 | 12
Sezary Syndrome 1 | 27
Tetanus 1 | 68
Tethered spinal cord syndrome 1 | 11
Urethral diverticulum 1 | 3
VACTERL association 1 | 26
Velocardiofacial syndrome 1 | 46

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Non-IDG 6 | 12,091
Enzyme 3 | 4,145
Kinase 1 | 634

Reactome Pathway

Prolonged ERK activation event... 10 | 10
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Fibroblast growth factor receptor substrate 2 FRS2 Tbio Non-IDG -2.37203 224.0 344
Kinase D-interacting substrate of 220 kDa KIDINS220 Tbio Enzyme -2.42897 262.3 191
Ras-related protein Rap-1A RAP1A Tchem Enzyme -2.40799 294.7 329
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482
Crk-like protein CRKL Tbio Non-IDG -2.20025 160.0 521
Adapter molecule crk CRK Tbio Non-IDG -2.55195 357.0 432
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 PLCG1 Tchem Enzyme -2.90339 786.2 846