Development Level

Tbio 12 | 11,445
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal sensory capabilities-... 1 | 8
absent vibrissae 1 | 12
decreased cardiac stroke volum... 1 | 6
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
enlarged testis 1 | 6
impaired righting response 1 | 26
increased fasted circulating g... 1 | 76
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
long tibia 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10

Disease

ovarian cancer 12 | 8,520
Carcinoma 9 | 11,493
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
osteosarcoma 5 | 7,950
Multiple myeloma 4 | 1,332
adult high grade glioma 4 | 3,801
glioblastoma 4 | 5,792
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
psoriasis 4 | 6,694
Autosomal recessive predisposition 3 | 1,442
ependymoma 3 | 4,679
lung cancer 3 | 4,740
medulloblastoma, large-cell 3 | 6,241
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Acquired scoliosis 2 | 281
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Cerebellar Ataxia 2 | 304
Curvature of spine 2 | 282
Dysarthria 2 | 192
Hyperreflexia 2 | 209
Neurodegenerative disease 2 | 414
Nystagmus 2 | 317
Optic Atrophy 2 | 242
Paraplegia 2 | 74
Pick disease 2 | 1,894
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Waldenstrons macroglobulinemia 2 | 765
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
atypical teratoid/rhabdoid tumor 2 | 357
breast carcinoma 2 | 1,638
diabetes mellitus 2 | 1,728
hereditary spastic paraplegia 2 | 318
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
tuberculosis 2 | 2,010
Abnormal coordination 1 | 15
Abnormality of the retinal vasculature 1 | 59
Adenocarcinoma 1 | 122
Adult onset 1 | 82
Animal Mammary Neoplasms 1 | 136
Ankylosing spondylitis 1 | 140
Atrophy of cerebellum 1 | 103
Babinski Reflex 1 | 100
Breast Neoplasms 1 | 445
Cerebellar degeneration 1 | 103
Cerebral atrophy 1 | 178
Chagas disease 1 | 39
Chronic progressive external ophthalmoplegia 1 | 26
Congenital pes cavus 1 | 88
Decreased lower limb vibratory sense 1 | 13
Degeneration of the lateral corticospinal tracts 1 | 6
Deglutition Disorders 1 | 132
Diarrhea 1 | 253
Enterobiasis 1 | 5
Esophageal Neoplasms 1 | 69
Forgetful 1 | 40
Gait Ataxia 1 | 51
Hydronephrosis 1 | 89
Infantile onset 1 | 238
Infratentorial atrophy 1 | 103
Lower limb spasticity 1 | 10
Macular degeneration 1 | 65
Malabsorption 1 | 82
Mammary Neoplasms 1 | 425
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Memory Loss 1 | 40
Memory impairment 1 | 40
Monoparesis - leg 1 | 27
Muscular Diseases 1 | 27
Nephrotic Syndrome 1 | 78
Neuropathy 1 | 261
Optic nerve disease 1 | 10
Osteoarthritis 1 | 184
Osteogenesis imperfecta 1 | 34
Overactive bladder syndrome 1 | 14
Proteinuria 1 | 144
Retinitis pigmentosa 3 1 | 16
Salmonellosis 1 | 42
Spastic Paraplegia 1 | 42
Spastic gait 1 | 23
Sphincter disturbances 1 | 16
Urethral diverticulum 1 | 3
Urethritis 1 | 10
Urgency frequency syndrome 1 | 14
Urgency of micturition 1 | 14
Urinary Incontinence 1 | 50
Uveitis 1 | 103
Weakness of lower limb 1 | 27
inflammatory breast cancer 1 | 286

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Non-IDG 8 | 12,091
Enzyme 5 | 4,145
Ion Channel 1 | 344

Reactome Pathway

Processing of SMDT1 14 | 14
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calcium uniporter protein, mitochondrial MCU Tbio Ion Channel -2.67075 458.1 25
Calcium uniporter regulatory subunit MCUb, mitochondrial MCUB Tdark Non-IDG -0.76467 3.88 57
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
ATP-dependent zinc metalloprotease YME1L1 YME1L1 Tbio Enzyme -2.42377 268.0 75
Prohibitin-2 PHB2 Tbio Non-IDG -2.95347 911.7 370
Stomatin-like protein 2, mitochondrial STOML2 Tbio Non-IDG -0.84987 9.04 154
Calcium uptake protein 2, mitochondrial MICU2 Tbio Non-IDG -0.94183 7.15 63
Mitochondrial-processing peptidase subunit alpha PMPCA Tbio Enzyme -1.94074 84.0 88
Paraplegin SPG7 Tbio Enzyme -2.81408 647.5 238
Essential MCU regulator, mitochondrial SMDT1 Tbio Non-IDG -1.60735 39.4 11