Development Level

Tbio 14 | 10,625
Tdark 6 | 7,003
Tclin 1 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
decreased circulating insulin ... 1 | 75
decreased lean body mass 1 | 195
enlarged spleen 1 | 26
hypoactivity 1 | 89
increased total body fat amoun... 1 | 57
male infertility 1 | 62
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

medulloblastoma, large-cell 11 | 6,234
glioblastoma 10 | 5,572
osteosarcoma 10 | 7,933
lung carcinoma 9 | 2,844
ovarian cancer 9 | 8,484
pilocytic astrocytoma 8 | 3,086
psoriasis 8 | 6,685
atypical teratoid / rhabdoid tumor 7 | 4,369
primitive neuroectodermal tumor 7 | 3,031
subependymal giant cell astrocytoma 7 | 2,287
Pick disease 6 | 1,893
Breast cancer 5 | 3,094
ependymoma 5 | 2,514
group 3 medulloblastoma 5 | 2,254
invasive ductal carcinoma 5 | 2,950
malignant mesothelioma 5 | 3,162
non-small cell lung cancer 5 | 2,798
pediatric high grade glioma 5 | 2,712
active Crohn's disease 4 | 918
astrocytic glioma 4 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
lung cancer 4 | 4,466
ulcerative colitis 4 | 2,087
Duchenne muscular dystrophy 3 | 602
Schizophrenia 3 | 501
breast carcinoma 3 | 1,614
cystic fibrosis 3 | 1,665
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,875
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
juvenile dermatomyositis 3 | 1,189
lung adenocarcinoma 3 | 2,713
oligodendroglioma 3 | 2,849
pancreatic cancer 3 | 2,300
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
Carcinoma 2 | 2,147
Multiple myeloma 2 | 1,327
Rheumatoid Arthritis 2 | 1,160
astrocytoma 2 | 1,493
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
medulloblastoma 2 | 1,524
non primary Sjogren syndrome sicca 2 | 840
non-inflammatory breast cancer 2 | 208
posterior fossa group A ependymoma 2 | 1,511
primary Sjogren syndrome 2 | 789
primary pancreatic ductal adenocarcinoma 2 | 1,271
sarcoidosis 2 | 358
Alcohol dependence 1 | 107
Becker muscular dystrophy 1 | 187
Bipolar Disorder 1 | 266
Charcot-Marie-Tooth disease 1 | 74
Colonic Neoplasms 1 | 126
Colorectal Neoplasms 1 | 217
Congenital stationary night blindness 1 | 27
Coronary artery disease 1 | 240
Depressive disorder 1 | 48
Diabetes Mellitus, Non-Insulin-Dependent 1 | 157
Dyspepsia 1 | 34
Epilepsy 1 | 346
Epilepsy characterized by intractable complex partial seizures 1 | 28
Esophageal Neoplasms 1 | 67
Essential Hypertension 1 | 82
Hypertension 1 | 287
Hypertensive disease 1 | 193
IGA Glomerulonephritis 1 | 454
Irritable bowel syndrome 1 | 59
Juvenile arthritis 1 | 124
Lennox-Gastaut syndrome 1 | 34
Liver diseases 1 | 66
Lymphoma 1 | 56
MYELODYSPLASTIC SYNDROME 1 | 36
Neurodegenerative disease 1 | 383
Neuropathy 1 | 210
Osteoporosis 1 | 257
Prostatic Neoplasms 1 | 471
Seizures 1 | 95
Simple partial seizure 1 | 26
Tonic-clonic epilepsy 1 | 47
Weight Gain 1 | 87
West Syndrome 1 | 23
active ulcerative colitis 1 | 477
acute quadriplegic myopathy 1 | 1,157
adrenocortical carcinoma 1 | 1,427
adult high grade glioma 1 | 2,148
atypical teratoid/rhabdoid tumor 1 | 1,095
chronic lymphosyte leukemia 1 | 232
colon cancer 1 | 1,475
diabetes mellitus 1 | 1,663
glioblastoma multiforme 1 | 347
head and neck cancer 1 | 270
hepatocellular carcinoma 1 | 532
mucosa-associated lymphoid tissue lymphoma 1 | 480
pancreatic carcinoma 1 | 567
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,795
severe Alzheimer's disease 1 | 49
tuberculosis 1 | 1,557
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 21 | 17,995
Digestive Tract 21 | 18,473
Endocrine System 21 | 18,512
Female tissues 21 | 18,647
Liver and Pancreas 21 | 18,136
Male tissues 21 | 17,969
Nervous System 21 | 18,561
Skin and soft tissues 21 | 18,115
Urinary Tract 21 | 18,444
Cardiovascular System 20 | 17,958
Respiratory system 19 | 17,484

Target Family

Non-IDG 17 | 11,971
Enzyme 3 | 4,146
Ion Channel 1 | 341

Reactome Pathway

Presynaptic function of Kainat... 21 | 21
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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