Development Level

Tbio 14 | 10,625
Tdark 6 | 7,003
Tclin 1 | 602

Collection

Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
decreased circulating insulin ... 1 | 75
decreased lean body mass 1 | 195
enlarged spleen 1 | 26
hypoactivity 1 | 89
increased total body fat amoun... 1 | 57
male infertility 1 | 62
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

medulloblastoma, large-cell 11 | 6,234
glioblastoma 10 | 5,572
osteosarcoma 10 | 7,933
lung carcinoma 9 | 2,844
ovarian cancer 9 | 8,491
pilocytic astrocytoma 8 | 3,086
psoriasis 8 | 6,685
atypical teratoid / rhabdoid tumor 7 | 4,369
primitive neuroectodermal tumor 7 | 3,031
subependymal giant cell astrocytoma 7 | 2,287
Pick disease 6 | 1,893
Breast cancer 5 | 3,098
ependymoma 5 | 2,514
group 3 medulloblastoma 5 | 2,254
invasive ductal carcinoma 5 | 2,950
malignant mesothelioma 5 | 3,163
non-small cell lung cancer 5 | 2,798
pediatric high grade glioma 5 | 2,712
active Crohn's disease 4 | 918
astrocytic glioma 4 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
lung cancer 4 | 4,473
ulcerative colitis 4 | 2,087
Duchenne muscular dystrophy 3 | 602
Schizophrenia 3 | 503
breast carcinoma 3 | 1,614
cystic fibrosis 3 | 1,670
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,875
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
juvenile dermatomyositis 3 | 1,189
lung adenocarcinoma 3 | 2,714
oligodendroglioma 3 | 2,849
pancreatic cancer 3 | 2,300
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
Carcinoma 2 | 2,147
MYELODYSPLASTIC SYNDROME 2 | 39
Multiple myeloma 2 | 1,327
Rheumatoid Arthritis 2 | 1,170
astrocytoma 2 | 1,493
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
medulloblastoma 2 | 1,524
non primary Sjogren syndrome sicca 2 | 840
non-inflammatory breast cancer 2 | 208
posterior fossa group A ependymoma 2 | 1,511
primary Sjogren syndrome 2 | 788
primary pancreatic ductal adenocarcinoma 2 | 1,271
sarcoidosis 2 | 368
Alcohol dependence 1 | 107
Becker muscular dystrophy 1 | 187
Bipolar Disorder 1 | 266
Charcot-Marie-Tooth disease 1 | 74
Colonic Neoplasms 1 | 126
Colorectal Neoplasms 1 | 217
Congenital stationary night blindness 1 | 28
Coronary artery disease 1 | 240
Depressive disorder 1 | 48
Diabetes Mellitus, Non-Insulin-Dependent 1 | 161
Dyspepsia 1 | 34
Epilepsy 1 | 346
Epilepsy characterized by intractable complex partial seizures 1 | 28
Esophageal Neoplasms 1 | 67
Essential Hypertension 1 | 82
Hypertension 1 | 293
Hypertensive disease 1 | 193
IGA Glomerulonephritis 1 | 454
Irritable bowel syndrome 1 | 59
Juvenile arthritis 1 | 124
Lennox-Gastaut syndrome 1 | 34
Liver diseases 1 | 66
Lymphoma 1 | 57
Neurodegenerative disease 1 | 383
Neuropathy 1 | 210
Osteoporosis 1 | 259
Prostatic Neoplasms 1 | 471
Seizures 1 | 95
Simple partial seizure 1 | 26
Tonic-clonic epilepsy 1 | 47
Weight Gain 1 | 87
West Syndrome 1 | 24
active ulcerative colitis 1 | 477
acute quadriplegic myopathy 1 | 1,157
adrenocortical carcinoma 1 | 1,427
adult high grade glioma 1 | 2,148
atypical teratoid/rhabdoid tumor 1 | 1,095
chronic lymphosyte leukemia 1 | 232
colon cancer 1 | 1,475
diabetes mellitus 1 | 1,663
glioblastoma multiforme 1 | 347
head and neck cancer 1 | 270
hepatocellular carcinoma 1 | 550
mucosa-associated lymphoid tissue lymphoma 1 | 480
pancreatic carcinoma 1 | 567
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,795
severe Alzheimer's disease 1 | 49
tuberculosis 1 | 1,563
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 21 | 17,994
Digestive Tract 21 | 18,472
Endocrine System 21 | 18,511
Female tissues 21 | 18,646
Liver and Pancreas 21 | 18,135
Male tissues 21 | 17,968
Nervous System 21 | 18,560
Skin and soft tissues 21 | 18,114
Urinary Tract 21 | 18,443
Cardiovascular System 20 | 17,957
Respiratory system 19 | 17,483

Target Family

Non-IDG 17 | 11,969
Enzyme 3 | 4,146
Ion Channel 1 | 341

Reactome Pathway

Presynaptic function of Kainat... 21 | 21
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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