Development Level

Tbio 32 | 11,445
Tchem 13 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased eosinophil cell numb... 2 | 24
decreased prepulse inhibition 2 | 82
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal kidney morphology 1 | 65
abnormal sensory capabilities-... 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased respiratory quotient 1 | 16
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged kidney 1 | 14
improved glucose tolerance 1 | 79
increased grip strength 1 | 41
increased lean body mass 1 | 172
preweaning lethality, incomple... 1 | 499
vertebral fusion 1 | 23

Disease

Carcinoma 36 | 11,493
osteosarcoma 30 | 7,950
ovarian cancer 29 | 8,520
medulloblastoma, large-cell 24 | 6,241
psoriasis 23 | 6,694
Cancer 20 | 2,499
glioblastoma 20 | 5,792
lung cancer 20 | 4,740
Breast cancer 19 | 3,578
atypical teratoid / rhabdoid tumor 17 | 5,112
group 3 medulloblastoma 14 | 4,104
Kidney cancer 13 | 2,613
astrocytic glioma 13 | 2,597
malignant mesothelioma 13 | 3,232
oligodendroglioma 13 | 2,850
ependymoma 12 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Pick disease 11 | 1,894
Rheumatoid arthritis 11 | 1,191
adult high grade glioma 11 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
invasive ductal carcinoma 10 | 2,951
lung carcinoma 10 | 2,843
non-small cell lung cancer 10 | 2,890
pancreatic cancer 10 | 2,398
primitive neuroectodermal tumor 10 | 3,035
tuberculosis 10 | 2,010
Astrocytoma, Pilocytic 9 | 3,081
Breast Neoplasms 9 | 445
Mammary Neoplasms 9 | 425
interstitial cystitis 9 | 2,312
Alzheimer's disease 8 | 658
Carcinoma, Squamous Cell 8 | 110
ductal carcinoma in situ 8 | 1,745
group 4 medulloblastoma 8 | 1,855
lung adenocarcinoma 8 | 2,716
subependymal giant cell astrocytoma 8 | 2,287
Adenoid Cystic Carcinoma 7 | 99
Carcinoma, Adenoid Cystic 7 | 99
Esophageal Squamous Cell Carcinoma 7 | 77
Liver cancer 7 | 604
Schizophrenia 7 | 1,160
Squamous cell carcinoma of esophagus 7 | 77
colon cancer 7 | 1,478
juvenile dermatomyositis 7 | 1,187
pituitary cancer 7 | 1,972
Epilepsy 6 | 792
Immune system cancer 6 | 140
Lymphoid leukemia 6 | 160
acute quadriplegic myopathy 6 | 1,158
astrocytoma 6 | 1,146
breast carcinoma 6 | 1,638
Acquired scoliosis 5 | 281
Amyotrophic lateral sclerosis 5 | 451
Bipolar Disorder 5 | 666
Curvature of spine 5 | 282
Failure to gain weight 5 | 365
Hydrocephalus 5 | 152
Hypertension 5 | 396
Lung Neoplasms 5 | 232
Multiple myeloma 5 | 1,332
Pediatric failure to thrive 5 | 365
Seizures 5 | 596
Short stature 5 | 531
Skin Neoplasms 5 | 69
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
nasopharyngeal carcinoma 5 | 1,058
pediatric high grade glioma 5 | 1,064
Autosomal recessive predisposition 4 | 1,442
Byzanthine arch palate 4 | 194
Carcinoma, Hepatocellular 4 | 228
Carcinoma, Transitional Cell 4 | 32
Cataract 4 | 297
Cerebrovascular disease 4 | 238
Colonic Neoplasms 4 | 142
Down syndrome 4 | 499
Endometrial cancer 4 | 311
Heart disease 4 | 306
Hypoplastic mandible condyle 4 | 275
Kidney disease 4 | 430
Lens Opacities 4 | 231
Liver carcinoma 4 | 240
Low set ears 4 | 181
Mandibular hypoplasia 4 | 275
Melanoma 4 | 711
Micrognathism 4 | 275
Muscle hypotonia 4 | 571
Skin cancer 4 | 469
Stomach Neoplasms 4 | 300
Strabismus 4 | 270
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
diabetes mellitus 4 | 1,728
pancreatic carcinoma 4 | 562
primary pancreatic ductal adenocarcinoma 4 | 1,109
progressive supranuclear palsy 4 | 676
spina bifida 4 | 1,074
ulcerative colitis 4 | 1,819

Tissue

Blood and immune system 46 | 16,909
Cardiovascular System 46 | 15,192
Digestive Tract 46 | 17,369
Endocrine System 46 | 18,159
Female tissues 46 | 17,400
Liver and Pancreas 46 | 16,750
Male tissues 46 | 17,142
Respiratory system 46 | 16,393
Skin and soft tissues 46 | 17,230
Urinary Tract 46 | 16,678
Nervous System 45 | 16,725

Target Family

Non-IDG 18 | 12,091
Enzyme 12 | 4,145
Transcription Factor 8 | 1,400
Epigenetic 4 | 242
Transporter 3 | 473
Kinase 1 | 634

Reactome Pathway

Pre-NOTCH Expression and Proce... 46 | 46
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Beta-1,3-N-acetylglucosaminyltransferase radical fringe RFNG Tdark Enzyme -0.37913 1.57 92
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.55297 38.5 121
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
ETS-related transcription factor Elf-3 ELF3 Tbio Transcription Factor -2.42034 268.3 328
Mastermind-like domain-containing protein 1 MAMLD1 Tbio Non-IDG -1.97732 91.2 52
Beta-1,3-N-acetylglucosaminyltransferase manic fringe MFNG Tbio Enzyme -0.83827 6.67 114
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 ATP2A3 Tbio Transporter -1.94217 94.1 100
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe LFNG Tbio Enzyme -1.50535 29.8 220