Development Level

Tclin 54 | 613
Tbio 26 | 11,445
Tchem 12 | 1,598
Tdark 6 | 6,588

Collection

Ion Channel: IDG Consortium (T... 23 | 99
RFA-RM-18-021 23 | 328

IMPC Phenotype

abnormal behavior 6 | 298
hyperactivity 5 | 148
increased bone mineral content 3 | 108
increased mean corpuscular vol... 3 | 92
abnormal behavioral response t... 2 | 66
abnormal epididymis morphology 2 | 42
enlarged epididymis 2 | 31
impaired glucose tolerance 2 | 75
increased mean platelet volume 2 | 45
preweaning lethality, complete... 2 | 979
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal locomotor behavior 1 | 24
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 36
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac stroke volum... 1 | 6
decreased circulating creatini... 1 | 39
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean platelet volume 1 | 25
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydroencephaly 1 | 14
increased body length 1 | 32
increased circulating serum al... 1 | 22
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased startle reflex 1 | 112
increased vertical activity 1 | 24
kyphosis 1 | 5
limb grasping 1 | 41
short tibia 1 | 97
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened QT interval 1 | 4
shortened ST segment 1 | 10
tremors 1 | 39

Disease

Carcinoma 72 | 11,493
ependymoma 51 | 4,679
medulloblastoma, large-cell 50 | 6,241
glioblastoma 46 | 5,792
atypical teratoid / rhabdoid tumor 43 | 5,112
Multiple Sclerosis 42 | 540
adult high grade glioma 42 | 3,801
Eaton-Lambert syndrome 40 | 40
group 3 medulloblastoma 39 | 4,104
primitive neuroectodermal tumor 38 | 3,035
Astrocytoma, Pilocytic 36 | 3,081
osteosarcoma 34 | 7,950
psoriasis 33 | 6,694
oligodendroglioma 30 | 2,850
astrocytic glioma 28 | 2,597
lung cancer 27 | 4,740
ovarian cancer 27 | 8,520
Kidney cancer 26 | 2,613
subependymal giant cell astrocytoma 24 | 2,287
lung carcinoma 22 | 2,843
malignant mesothelioma 21 | 3,232
pituitary cancer 21 | 1,972
Epilepsy 19 | 792
Breast cancer 17 | 3,578
interstitial cystitis 15 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Atrial Fibrillation 14 | 124
Pick disease 14 | 1,894
Intellectual disability 13 | 1,016
Long QT syndrome 12 | 39
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
lung adenocarcinoma 12 | 2,716
non-small cell lung cancer 12 | 2,890
Schizophrenia 11 | 1,160
Seizures 11 | 596
cystic fibrosis 11 | 1,696
invasive ductal carcinoma 11 | 2,951
pancreatic cancer 11 | 2,398
adrenocortical carcinoma 10 | 1,428
colon cancer 10 | 1,478
ductal carcinoma in situ 9 | 1,745
group 4 medulloblastoma 9 | 1,855
Heart disease 8 | 306
Muscle hypotonia 8 | 571
Paroxysmal atrial fibrillation 8 | 14
Bipolar Disorder 7 | 666
Cognitive delay 7 | 608
Dull intelligence 7 | 645
Episodic ataxia 7 | 22
Global developmental delay 7 | 608
Low intelligence 7 | 645
Melanoma 7 | 711
Mental Retardation 7 | 645
Mental and motor retardation 7 | 608
Mental deficiency 7 | 645
Poor school performance 7 | 645
Skin cancer 7 | 469
Birk-Barel syndrome 6 | 8
Depressive disorder 6 | 409
Hypertension 6 | 396
Hypokalemia 6 | 52
Mental Depression 6 | 333
Schnyder Corneal Dystrophy 6 | 23
active ulcerative colitis 6 | 764
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
tuberculosis 6 | 2,010
Autosomal recessive predisposition 5 | 1,442
Brugada syndrome 5 | 29
Cerebellar Ataxia 5 | 304
Failure to gain weight 5 | 365
Familial atrial fibrillation 5 | 23
General anesthesia 5 | 53
Hyperaldosteronism 5 | 35
Infantile onset 5 | 238
Liver cancer 5 | 604
Long philtrum 5 | 137
Myoclonus 5 | 74
Osteoporosis 5 | 363
Pediatric failure to thrive 5 | 365
Type 2 diabetes mellitus 5 | 272
astrocytoma 5 | 1,146
breast carcinoma 5 | 1,638
diabetes mellitus 5 | 1,728
gastric carcinoma 5 | 807
progressive supranuclear palsy 5 | 676
sonic hedgehog group medulloblastoma 5 | 467
ulcerative colitis 5 | 1,819
Byzanthine arch palate 4 | 194
Congenital Epicanthus 4 | 177
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Down syndrome 4 | 499
Duchenne muscular dystrophy 4 | 601
Hepatomegaly 4 | 285
Vascular disease 4 | 319
acute quadriplegic myopathy 4 | 1,158
chronic rhinosinusitis 4 | 512
pediatric high grade glioma 4 | 1,064
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Endocrine System 97 | 18,159
Nervous System 93 | 16,725
Digestive Tract 90 | 17,369
Female tissues 89 | 17,400
Male tissues 87 | 17,142
Skin and soft tissues 86 | 17,230
Liver and Pancreas 83 | 16,750
Urinary Tract 81 | 16,678
Respiratory system 79 | 16,393
Blood and immune system 78 | 16,909
Cardiovascular System 68 | 15,192

Target Family

Ion Channel 82 | 344
Non-IDG 13 | 12,091
GPCR 2 | 408
Transporter 1 | 473

Reactome Pathway

Potassium Channels 98 | 98
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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