Development Level

Tclin 7 | 613
Tchem 4 | 1,598
Tbio 1 | 11,445

Collection

Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

abnormal epididymis morphology 1 | 42
decreased body weight 1 | 161
enlarged heart 1 | 210
increased lean body mass 1 | 172
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 11 | 11,493
Nicotine dependence 10 | 54
Frontal lobe epilepsy 6 | 10
Seizures 6 | 596
psoriasis 6 | 6,694
Alcohol dependence 5 | 107
Alcoholic Intoxication, Chronic 5 | 289
Cocaine Dependence 5 | 51
Niacin deficiency 5 | 5
Nicotine Withdrawal Symptoms 5 | 5
Pellagra 5 | 26
Smoking cessation assistance 5 | 8
TOBACCO ADDICTION, SUSCEPTIBILITY TO 5 | 12
TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) 5 | 12
Depressive disorder 4 | 409
Lung Neoplasms 4 | 232
Mental Depression 4 | 333
Schizophrenia 4 | 1,160
Substance Withdrawal Syndrome 4 | 55
glioblastoma 4 | 5,792
substance-related disorder 4 | 162
Autosomal dominant nocturnal frontal lobe epilepsy 3 | 4
Autosomal recessive predisposition 3 | 1,442
Bipolar Disorder 3 | 666
Blepharoptosis 3 | 231
Byzanthine arch palate 3 | 194
Chronic obstructive pulmonary disease 3 | 184
Epilepsy 3 | 792
General anesthesia 3 | 53
Hypertensive disorder 3 | 56
Multiple pterygium syndrome 3 | 18
Muscle relaxation, function 3 | 8
Skeletal Muscle Relaxation for Endotracheal Intubation 3 | 5
Skeletal Muscle Relaxation for Endotracheal Intubation in C-Section 3 | 5
adult high grade glioma 3 | 3,801
atypical teratoid / rhabdoid tumor 3 | 5,112
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
osteosarcoma 3 | 7,950
Abnormal behavior 2 | 52
Akinesia 2 | 13
Alcoholism 2 | 45
Alzheimer's disease 2 | 658
Anxiety Disorders 2 | 38
Arthrogryposis 2 | 54
Attention Deficit Disorder with Hyperactivity 2 | 21
Autistic Disorder 2 | 364
Bell Palsy 2 | 58
Congenital Epicanthus 2 | 177
Congenital Myasthenic Syndromes, Postsynaptic 2 | 11
Congenital anomaly of face 2 | 56
Congenital myasthenic syndrome 2 | 25
Contracture 2 | 96
Contracture of joint 2 | 93
Controlled Hypotension 2 | 6
Cystic lymphangioma 2 | 19
Deglutition Disorders 2 | 132
Distortion of face 2 | 46
Dysmorphic facies 2 | 46
Early severe fetal akinesia sequence 2 | 11
Easy fatigability 2 | 18
Edema 2 | 81
Epilepsy, Frontal Lobe 2 | 4
Facial Paresis 2 | 59
Facial muscle weakness of muscles innervated by CN VII 2 | 58
Flexion contracture 2 | 93
Flexion contractures of joints 2 | 93
Funny looking face 2 | 46
Fused vertebrae 2 | 25
Hypertensive Emergencies 2 | 10
Hypoplastic finger 2 | 17
Increased susceptibility to fractures 2 | 21
Infantile onset 2 | 238
Inflammation 2 | 120
Lymphangioma, Cystic 2 | 21
MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE 2 | 5
Malignant hyperpyrexia due to anesthesia 2 | 10
Neck muscle weakness 2 | 17
Neonatal Hypotonia 2 | 64
Neuropathy 2 | 261
Ophthalmoplegia 2 | 106
Pena-Shokeir syndrome type I 2 | 12
Polyhydramnios 2 | 108
Prenatal onset 2 | 139
Pulmonary edema 2 | 17
Reduced fetal movement 2 | 51
Refractive error 2 | 50
Respiratory Insufficiency 2 | 132
Respiratory function loss 2 | 121
Scoliosis 2 | 44
Short finger 2 | 17
Sleep Wake Disorders 2 | 7
Spinal fusion 2 | 25
Sudden infant death syndrome 2 | 32
Thin rib 2 | 21
Tires quickly 2 | 18
Vertebral body fusion 2 | 25
cocaine use 2 | 11
facial deformity 2 | 46
pterygium 2 | 76

Tissue

Endocrine System 11 | 18,159
Nervous System 10 | 16,725
Blood and immune system 9 | 16,909
Female tissues 9 | 17,400
Male tissues 9 | 17,142
Skin and soft tissues 9 | 17,230
Digestive Tract 8 | 17,369
Liver and Pancreas 8 | 16,750
Urinary Tract 7 | 16,678
Respiratory system 6 | 16,393
Cardiovascular System 3 | 15,192

Target Family

Ion Channel 12 | 344

Reactome Pathway

Postsynaptic nicotinic acetylc... 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuronal acetylcholine receptor subunit beta-2 CHRNB2 Tclin Ion Channel -1.62448 37.6 174
Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 Tchem Ion Channel -1.31722 18.3 117
Neuronal acetylcholine receptor subunit beta-4 CHRNB4 Tclin Ion Channel -1.57182 33.7 130
Acetylcholine receptor subunit delta CHRND Tclin Ion Channel -1.30154 18.9 155
Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 Tbio Ion Channel -2.15575 143.1 237
Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 Tchem Ion Channel -1.19275 14.0 83
Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 Tclin Ion Channel -3.62589 4263.7 202
Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Tclin Ion Channel -1.99577 92.1 193
Acetylcholine receptor subunit epsilon CHRNE Tclin Ion Channel -1.66048 45.3 117
Neuronal acetylcholine receptor subunit beta-3 CHRNB3 Tchem Ion Channel -1.27029 20.2 103