Development Level

Tbio 1,052 | 11,651
Tdark 192 | 6,593
Tchem 120 | 1,388
Tclin 34 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 136 | 979
preweaning lethality, incomple... 48 | 499
embryonic lethality prior to t... 29 | 278
embryonic lethality prior to o... 28 | 239
decreased total body fat amoun... 23 | 207
enlarged heart 20 | 210
abnormal behavior 19 | 298
abnormal embryo size 19 | 220
decreased body weight 18 | 161
abnormal seminal vesicle morph... 17 | 114
abnormal heart morphology 16 | 162
decreased circulating choleste... 16 | 93
decreased bone mineral content 15 | 151
decreased vertical activity 15 | 208
decreased lean body mass 14 | 135
decreased circulating glucose ... 13 | 126
increased mean corpuscular vol... 13 | 92
decreased hemoglobin content 12 | 68
increased mean corpuscular hem... 12 | 96
hypoactivity 11 | 132
increased circulating alkaline... 11 | 122
increased lean body mass 11 | 172
increased total body fat amoun... 11 | 134
decreased circulating HDL chol... 10 | 68
decreased circulating serum al... 10 | 82
decreased mean corpuscular hem... 10 | 50
embryonic growth retardation 10 | 106
short tibia 10 | 97
abnormal bone structure 9 | 187
cataract 9 | 92
decreased circulating alanine ... 9 | 47
increased blood urea nitrogen ... 9 | 48
prenatal lethality prior to he... 9 | 87
anophthalmia 8 | 33
decreased body length 8 | 101
decreased circulating LDL chol... 8 | 38
decreased circulating aspartat... 8 | 34
decreased circulating total pr... 8 | 49
increased circulating HDL chol... 8 | 80
increased circulating triglyce... 8 | 42
male infertility 8 | 123
abnormal lens morphology 7 | 81
decreased circulating creatini... 7 | 39
decreased circulating fructosa... 7 | 30
decreased erythrocyte cell num... 7 | 62
edema 7 | 59
impaired glucose tolerance 7 | 75
increased mean platelet volume 7 | 45
abnormal coat-hair pigmentatio... 6 | 64
abnormal craniofacial morpholo... 6 | 33
abnormal kidney morphology 6 | 65
abnormal neural tube closure 6 | 46
decreased blood urea nitrogen ... 6 | 51
decreased bone mineral density 6 | 126
decreased caudal vertebrae num... 6 | 53
decreased circulating insulin ... 6 | 76
decreased circulating triglyce... 6 | 79
decreased grip strength 6 | 116
decreased hematocrit 6 | 46
decreased red blood cell distr... 6 | 41
decreased startle reflex 6 | 75
hyperactivity 6 | 148
increased bone mineral content 6 | 108
increased circulating chloride... 6 | 41
increased circulating choleste... 6 | 66
increased heart weight 6 | 62
increased hematocrit 6 | 46
increased hemoglobin content 6 | 45
increased mean corpuscular hem... 6 | 36
increased or absent threshold ... 6 | 101
increased startle reflex 6 | 112
prolonged ST segment 6 | 36
syndactyly 6 | 23
thrombocytopenia 6 | 56
thrombocytosis 6 | 27
abnormal cranium morphology 5 | 36
abnormal eye morphology 5 | 68
abnormal facial morphology 5 | 17
abnormal limb bud morphology 5 | 17
abnormal limb morphology 5 | 13
abnormal sleep behavior 5 | 70
abnormal tooth morphology 5 | 24
brachydactyly 5 | 19
cardiovascular system phenotyp... 5 | 36
decreased leukocyte cell numbe... 5 | 73
decreased mean corpuscular vol... 5 | 79
decreased prepulse inhibition 5 | 82
hydrometra 5 | 53
increased circulating creatini... 5 | 38
increased circulating sodium l... 5 | 71
increased fasted circulating g... 5 | 76
increased red blood cell distr... 5 | 34
long tibia 5 | 25
prolonged QT interval 5 | 38
vertebral fusion 5 | 23
corneal opacity 4 | 32
decreased circulating free fat... 4 | 31
increased circulating total pr... 4 | 28
pale yolk sac 4 | 25
small testis 4 | 58

Disease

Carcinoma 861 | 11,493
ovarian cancer 781 | 8,520
osteosarcoma 623 | 7,950
psoriasis 531 | 6,694
glioblastoma 487 | 5,792
medulloblastoma, large-cell 462 | 6,241
atypical teratoid / rhabdoid tumor 421 | 5,112
lung cancer 413 | 4,740
ependymoma 344 | 4,679
Breast cancer 315 | 3,578
Cancer 307 | 2,499
adult high grade glioma 282 | 3,801
malignant mesothelioma 275 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 267 | 3,291
group 3 medulloblastoma 264 | 4,104
non-small cell lung cancer 252 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 247 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 239 | 2,989
lung adenocarcinoma 237 | 2,716
Astrocytoma, Pilocytic 225 | 3,081
invasive ductal carcinoma 225 | 2,951
primitive neuroectodermal tumor 222 | 3,035
oligodendroglioma 217 | 2,850
pancreatic cancer 217 | 2,398
diabetes mellitus 211 | 1,728
Kidney cancer 208 | 2,613
astrocytic glioma 206 | 2,597
lung carcinoma 193 | 2,843
tuberculosis 190 | 2,010
Multiple myeloma 185 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 169 | 1,962
subependymal giant cell astrocytoma 156 | 2,287
Rheumatoid arthritis 148 | 1,191
group 4 medulloblastoma 148 | 1,855
cystic fibrosis 146 | 1,696
Pick disease 143 | 1,894
pituitary cancer 142 | 1,972
dermatomyositis 140 | 966
Autosomal recessive predisposition 136 | 1,442
breast carcinoma 133 | 1,638
interstitial cystitis 131 | 2,312
ulcerative colitis 130 | 1,819
juvenile dermatomyositis 121 | 1,187
acute quadriplegic myopathy 117 | 1,158
ductal carcinoma in situ 115 | 1,745
adrenocortical carcinoma 110 | 1,428
astrocytoma 106 | 1,146
colon cancer 100 | 1,478
Intellectual disability 99 | 1,016
primary pancreatic ductal adenocarcinoma 90 | 1,109
pediatric high grade glioma 88 | 1,064
Epilepsy 85 | 792
nasopharyngeal carcinoma 83 | 1,058
Waldenstrons macroglobulinemia 82 | 765
active Crohn's disease 80 | 922
Arthritis 79 | 290
spina bifida 79 | 1,074
Schizophrenia 76 | 1,160
cutaneous lupus erythematosus 76 | 1,057
Hypersensitivity reaction type II disease 75 | 253
Seizures 74 | 596
non primary Sjogren syndrome sicca 74 | 891
Muscle hypotonia 72 | 571
esophageal adenocarcinoma 68 | 737
gastric carcinoma 67 | 807
Acquired immunodeficiency syndrome 66 | 197
Atopic dermatitis 66 | 952
acute myeloid leukemia 66 | 783
Cognitive delay 65 | 608
Global developmental delay 65 | 608
Kidney disease 65 | 430
Mental and motor retardation 65 | 608
hepatocellular carcinoma 63 | 547
Ankylosing spondylitis 61 | 140
Duchenne muscular dystrophy 61 | 601
Juvenile rheumatoid arthritis 60 | 111
Uveitis 60 | 103
active ulcerative colitis 60 | 764
Dull intelligence 59 | 645
Low intelligence 59 | 645
Melanoma 59 | 711
Mental Retardation 59 | 645
Mental deficiency 59 | 645
Poor school performance 59 | 645
Prostatic Neoplasms 59 | 495
Short stature 58 | 531
Anemia 57 | 365
Behcet's disease 56 | 89
Herpes zoster 56 | 68
autosomal dominant Emery-Dreifuss muscular dystrophy 56 | 510
Alzheimer's disease 55 | 658
Liver disease 55 | 237
medulloblastoma 54 | 720
Liver Cirrhosis, Experimental 53 | 769
primary Sjogren syndrome 51 | 735
Small head 50 | 374
pancreatic carcinoma 50 | 562
Stevens-Johnson syndrome 49 | 92
posterior fossa group A ependymoma 49 | 468
Endometriosis 48 | 540

Tissue

Endocrine System 1,306 | 18,159
Female tissues 1,292 | 17,400
Skin and soft tissues 1,289 | 17,230
Digestive Tract 1,288 | 17,369
Male tissues 1,276 | 17,142
Liver and Pancreas 1,273 | 16,750
Urinary Tract 1,268 | 16,678
Blood and immune system 1,266 | 16,909
Nervous System 1,262 | 16,725
Respiratory system 1,252 | 16,393
Cardiovascular System 1,206 | 15,192

Target Family

Non-IDG 791 | 12,091
Enzyme 527 | 4,145
Transcription Factor 33 | 1,400
Epigenetic 21 | 242
Kinase 17 | 634
Transporter 3 | 473
Ion Channel 2 | 344
Nuclear Receptor 2 | 48
GPCR 1 | 408
TF/Epigenetic 1 | 38

Reactome Pathway

Post-translational protein mod... 1,398 | 1,398
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Amelogenin, X isoform AMELX Tbio Non-IDG -2.84702 695.0 136
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0