Development Level

Tbio 717 | 10,625
Tdark 137 | 7,003
Tchem 131 | 1,890
Tclin 20 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 85 | 633
embryonic lethality prior to t... 20 | 187
decreased lean body mass 15 | 195
preweaning lethality, incomple... 15 | 260
decreased body weight 13 | 174
embryonic lethality prior to o... 13 | 148
increased circulating alkaline... 13 | 119
decreased circulating choleste... 12 | 85
decreased total body fat amoun... 12 | 186
abnormal behavior 11 | 226
enlarged heart 10 | 111
increased sacral vertebrae num... 10 | 62
decreased bone mineral content 9 | 157
increased mean corpuscular vol... 9 | 91
decreased circulating glucose ... 8 | 121
decreased circulating triglyce... 8 | 83
decreased grip strength 8 | 123
decreased lumbar vertebrae num... 8 | 62
increased mean corpuscular hem... 8 | 93
decreased body length 7 | 108
decreased caudal vertebrae num... 7 | 49
decreased circulating HDL chol... 7 | 77
decreased hemoglobin content 7 | 53
increased or absent threshold ... 7 | 128
prenatal lethality prior to he... 7 | 64
abnormal lens morphology 6 | 73
abnormal retinal pigmentation 6 | 61
decreased circulating LDL chol... 6 | 37
decreased circulating alanine ... 6 | 53
increased exploration in new e... 6 | 56
increased grip strength 6 | 83
short tibia 6 | 82
abnormal heart morphology 5 | 51
decreased B cell number 5 | 30
decreased T cell number 5 | 31
decreased circulating fructosa... 5 | 31
decreased circulating insulin ... 5 | 75
decreased circulating total pr... 5 | 41
decreased effector memory CD8-... 5 | 24
decreased mean corpuscular hem... 5 | 34
decreased rib number 5 | 59
decreased startle reflex 5 | 48
increased CD4-positive, alpha ... 5 | 15
increased circulating sodium l... 5 | 71
increased heart weight 5 | 37
thrombocytopenia 5 | 46
thrombocytosis 5 | 23
abnormal bone mineralization 4 | 55
abnormal coat/hair pigmentatio... 4 | 54
abnormal embryo size 4 | 112
abnormal gait 4 | 51
abnormal seminal vesicle morph... 4 | 47
anophthalmia 4 | 20
cataract 4 | 26
decreased CD4-positive, CD25-p... 4 | 24
decreased CD8-positive, alpha-... 4 | 26
decreased KLRG1-positive NK ce... 4 | 9
decreased Ly6C low monocyte nu... 4 | 23
decreased bone mineral density 4 | 126
decreased circulating aspartat... 4 | 27
decreased circulating free fat... 4 | 39
decreased circulating serum al... 4 | 79
decreased eosinophil cell numb... 4 | 41
decreased mean corpuscular vol... 4 | 50
hypoactivity 4 | 89
increased blood urea nitrogen ... 4 | 44
increased circulating chloride... 4 | 43
increased circulating triglyce... 4 | 24
increased fasted circulating g... 4 | 68
increased monocyte cell number 4 | 27
polydactyly 4 | 22
vertebral fusion 4 | 23
abnormal bone structure 3 | 131
abnormal cranium morphology 3 | 32
abnormal retina morphology 3 | 100
abnormal testis morphology 3 | 30
cardiovascular system phenotyp... 3 | 35
corneal opacity 3 | 25
decreased NK T cell number 3 | 28
decreased blood urea nitrogen ... 3 | 31
decreased circulating alkaline... 3 | 41
decreased circulating calcium ... 3 | 33
decreased fasted circulating g... 3 | 49
decreased gamma-delta T cell n... 3 | 18
decreased hematocrit 3 | 25
decreased lactate dehydrogenas... 3 | 14
hydrometra 3 | 13
increased B cell number 3 | 23
increased NK cell number 3 | 19
increased T cell number 3 | 15
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased effector memory CD4-... 3 | 15
increased granulocyte number 3 | 8
increased hematocrit 3 | 36
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 25
increased total body fat amoun... 3 | 57
limb grasping 3 | 35
small testis 3 | 37

Disease

ovarian cancer 577 | 8,484
osteosarcoma 477 | 7,933
psoriasis 368 | 6,685
glioblastoma 350 | 5,572
medulloblastoma, large-cell 328 | 6,234
lung cancer 298 | 4,466
atypical teratoid / rhabdoid tumor 272 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 209 | 3,289
Breast cancer 202 | 3,094
malignant mesothelioma 191 | 3,162
lung adenocarcinoma 189 | 2,713
non-small cell lung cancer 183 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 179 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 178 | 2,988
Cancer 170 | 2,346
pilocytic astrocytoma 166 | 3,086
invasive ductal carcinoma 160 | 2,950
oligodendroglioma 158 | 2,849
pediatric high grade glioma 155 | 2,712
primitive neuroectodermal tumor 155 | 3,031
pancreatic cancer 149 | 2,300
Multiple myeloma 147 | 1,327
lung carcinoma 135 | 2,844
ependymoma 133 | 2,514
group 3 medulloblastoma 131 | 2,254
Carcinoma 127 | 2,147
astrocytic glioma 127 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 122 | 1,795
subependymal giant cell astrocytoma 109 | 2,287
ulcerative colitis 109 | 2,087
Pick disease 108 | 1,893
cystic fibrosis 106 | 1,665
adult high grade glioma 104 | 2,148
astrocytoma 100 | 1,493
diabetes mellitus 99 | 1,663
interstitial cystitis 97 | 2,299
pituitary cancer 97 | 1,972
posterior fossa group A ependymoma 97 | 1,511
medulloblastoma 89 | 1,524
breast carcinoma 88 | 1,614
group 4 medulloblastoma 87 | 1,875
tuberculosis 87 | 1,557
ductal carcinoma in situ 86 | 1,745
Rheumatoid Arthritis 84 | 1,160
juvenile dermatomyositis 79 | 1,189
dermatomyositis 78 | 933
acute quadriplegic myopathy 77 | 1,157
adrenocortical carcinoma 74 | 1,427
colon cancer 69 | 1,475
active Crohn's disease 63 | 918
posterior fossa group B ependymoma 63 | 1,530
primary pancreatic ductal adenocarcinoma 63 | 1,271
Waldenstrons macroglobulinemia 61 | 765
cutaneous lupus erythematosus 61 | 1,056
sonic hedgehog group medulloblastoma 61 | 1,482
spina bifida 61 | 1,064
nasopharyngeal carcinoma 58 | 1,056
acute myeloid leukemia 55 | 780
atypical teratoid/rhabdoid tumor 53 | 1,095
non primary Sjogren syndrome sicca 52 | 840
tuberculosis and treatment for 6 months 52 | 686
esophageal adenocarcinoma 51 | 737
Atopic dermatitis 48 | 944
Intellectual disability 47 | 573
hepatocellular carcinoma 43 | 532
pancreatic carcinoma 42 | 567
primary Sjogren syndrome 42 | 789
Prostatic Neoplasms 41 | 471
Congenital disorder of glycosylation 39 | 53
IGA Glomerulonephritis 39 | 454
gastric carcinoma 39 | 832
non-small cell lung carcinoma 37 | 413
Alzheimer's disease 35 | 644
Endometriosis 32 | 535
aldosterone-producing adenoma 31 | 664
gastric cancer 30 | 430
inflammatory breast cancer 29 | 404
Amyotrophic Lateral Sclerosis 28 | 431
Duchenne muscular dystrophy 28 | 602
Mammary Neoplasms 28 | 410
Parkinson's disease 28 | 364
Schizophrenia 28 | 501
active ulcerative colitis 28 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 499
Vascular disease 27 | 281
Stomach Neoplasms 26 | 282
fibroadenoma 25 | 557
Down syndrome 23 | 548
HIV Infections 23 | 100
Melanoma 23 | 261
Neurodegenerative disease 23 | 383
Obesity 23 | 616
mucosa-associated lymphoid tissue lymphoma 23 | 480
progressive supranuclear palsy 23 | 674
Asthma 21 | 349
Crohn's disease 21 | 304
Kidney disease 21 | 396
Liver carcinoma 21 | 217
tuberculosis and treatment for 3 months 21 | 327
Autistic Disorder 20 | 320

Tissue

Nervous System 994 | 18,561
Female tissues 992 | 18,647
Blood and immune system 987 | 17,995
Digestive Tract 982 | 18,473
Urinary Tract 982 | 18,444
Endocrine System 979 | 18,512
Liver and Pancreas 978 | 18,136
Male tissues 976 | 17,969
Cardiovascular System 969 | 17,958
Skin and soft tissues 965 | 18,115
Respiratory system 962 | 17,484

Target Family

Enzyme 486 | 4,146
Non-IDG 453 | 11,971
Transcription Factor 26 | 1,400
Kinase 16 | 634
Epigenetic 15 | 242
Transporter 3 | 473
Ion Channel 2 | 341
Nuclear Receptor 2 | 48
GPCR 1 | 406
TF/Epigenetic 1 | 38

Reactome Pathway

Post-translational protein mod... 1,005 | 1,005
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
Properdin CFP Tbio Non-IDG -3.16935 1491.5 297
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
Xaa-Pro aminopeptidase 2 XPNPEP2 Tchem Enzyme -1.55651 32.2 97
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
N-acylglucosamine 2-epimerase RENBP Tbio Enzyme -1.52686 33.5 80
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A MGAT5 Tchem Enzyme -2.07315 133.7 104