Development Level

Tbio 49 | 10,625
Tdark 14 | 7,003
Tchem 5 | 1,890
Tclin 3 | 602

IMPC Phenotype

preweaning lethality, complete... 4 | 633
decreased body weight 3 | 174
abnormal behavior 2 | 226
decreased lumbar vertebrae num... 2 | 62
embryonic lethality prior to o... 2 | 148
increased sacral vertebrae num... 2 | 62
abnormal bone mineralization 1 | 55
abnormal maxilla morphology 1 | 16
abnormal tooth morphology 1 | 24
decreased Ly6C low monocyte nu... 1 | 23
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased heart left ventricle... 1 | 2
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased rib number 1 | 59
embryonic lethality prior to t... 1 | 187
hypoactivity 1 | 89
increased circulating alkaline... 1 | 119
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased plasma cell number 1 | 5
thick ventricular wall 1 | 7
thin ventricular wall 1 | 5
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

ovarian cancer 42 | 8,491
osteosarcoma 30 | 7,933
psoriasis 28 | 6,685
lung cancer 27 | 4,473
Cancer 19 | 2,346
glioblastoma 19 | 5,572
lung adenocarcinoma 18 | 2,714
medulloblastoma, large-cell 18 | 6,234
Breast cancer 17 | 3,098
Multiple myeloma 17 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
primitive neuroectodermal tumor 14 | 3,031
invasive ductal carcinoma 13 | 2,950
atypical teratoid / rhabdoid tumor 11 | 4,369
ductal carcinoma in situ 11 | 1,745
ependymoma 11 | 2,514
group 3 medulloblastoma 11 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
non-small cell lung cancer 11 | 2,798
breast carcinoma 10 | 1,614
pediatric high grade glioma 10 | 2,712
astrocytoma 9 | 1,493
group 4 medulloblastoma 9 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
malignant mesothelioma 9 | 3,163
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
sonic hedgehog group medulloblastoma 9 | 1,482
Rheumatoid Arthritis 8 | 1,170
Waldenstrons macroglobulinemia 8 | 764
colon cancer 8 | 1,475
oligodendroglioma 8 | 2,849
pancreatic cancer 8 | 2,300
Carcinoma 7 | 2,147
atypical teratoid/rhabdoid tumor 7 | 1,095
dermatomyositis 7 | 966
diabetes mellitus 7 | 1,663
subependymal giant cell astrocytoma 7 | 2,287
Endometriosis 6 | 535
acute myeloid leukemia 6 | 785
astrocytic glioma 6 | 2,241
spina bifida 6 | 1,064
Intellectual disability 5 | 573
Pick disease 5 | 1,893
acute quadriplegic myopathy 5 | 1,157
adult high grade glioma 5 | 2,148
cutaneous lupus erythematosus 5 | 1,056
cystic fibrosis 5 | 1,670
medulloblastoma 5 | 1,524
nasopharyngeal carcinoma 5 | 1,056
non-small cell lung carcinoma 5 | 413
pilocytic astrocytoma 5 | 3,086
posterior fossa group A ependymoma 5 | 1,511
Mammary Neoplasms 4 | 410
primary pancreatic ductal adenocarcinoma 4 | 1,271
Bipolar Disorder 3 | 266
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Dementia 3 | 129
Down syndrome 3 | 548
Leishmaniasis 3 | 49
Lung Neoplasms 3 | 171
Lupus erythematosus 3 | 80
Melanoma 3 | 261
Schizophrenia 3 | 503
Treacher Collins syndrome 3 | 29
active Crohn's disease 3 | 918
gastric cancer 3 | 436
gastric carcinoma 3 | 832
juvenile dermatomyositis 3 | 1,189
lung carcinoma 3 | 2,844
pancreatic carcinoma 3 | 567
pituitary cancer 3 | 1,972
tuberculosis 3 | 1,563
Alzheimer's disease 2 | 644
Attention deficit hyperactivity disorder 2 | 156
Autistic Disorder 2 | 320
Cardiomegaly 2 | 66
Craniofacial Abnormalities 2 | 147
Dystonia 2 | 77
Endometrial Neoplasms 2 | 50
Juvenile rheumatoid arthritis 2 | 105
Neoplasm Invasiveness 2 | 127
Neurodegenerative disease 2 | 383
Peripheral T-cell lymphoma 2 | 24
Primary cutaneous T-cell lymphoma 2 | 29
Squamous cell carcinoma 2 | 96
Squamous cell carcinoma of esophagus 2 | 82
Vaccinia 2 | 37
Vascular disease 2 | 281
Williams-Beuren syndrome 2 | 45
adrenocortical carcinoma 2 | 1,427
chronic lymphocytic leukemia 2 | 244
glioblastoma multiforme 2 | 347
hepatocellular carcinoma 2 | 550
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299
mucosa-associated lymphoid tissue lymphoma 2 | 480
primary Sjogren syndrome 2 | 788
tuberculosis and treatment for 3 months 2 | 327
ulcerative colitis 2 | 2,087

Tissue

Female tissues 71 | 18,646
Male tissues 71 | 17,968
Blood and immune system 70 | 17,994
Cardiovascular System 70 | 17,957
Digestive Tract 70 | 18,472
Endocrine System 70 | 18,511
Nervous System 70 | 18,560
Urinary Tract 70 | 18,443
Liver and Pancreas 69 | 18,135
Respiratory system 69 | 17,483
Skin and soft tissues 63 | 18,114

Target Family

Non-IDG 36 | 11,969
Enzyme 18 | 4,146
Epigenetic 10 | 242
Transcription Factor 6 | 1,400
Kinase 1 | 634

Reactome Pathway

Positive epigenetic regulation... 71 | 71
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.14104 13.5 159
Transcriptional repressor p66-alpha GATAD2A Tbio Non-IDG -0.83060 7.11 142
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.89072 7.36 47
Histone-binding protein RBBP4 RBBP4 Tbio Non-IDG -1.68453 51.8 276
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -1.95009 79.5 294