Development Level

Tbio 55 | 11,651
Tdark 11 | 6,593
Tchem 4 | 1,388
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to o... 3 | 239
abnormal behavior 2 | 298
decreased body weight 2 | 161
embryonic lethality prior to t... 2 | 278
abnormal bone mineralization 1 | 38
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal posture 1 | 2
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lumbar vertebrae num... 1 | 2
decreased sacral vertebrae num... 1 | 1
hemorrhage 1 | 23
hypoactivity 1 | 132
increased body temperature 1 | 9
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased lumbar vertebrae num... 1 | 1
increased sacral vertebrae num... 1 | 1
increased total body fat amoun... 1 | 134
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

ovarian cancer 42 | 8,520
Carcinoma 40 | 11,493
osteosarcoma 30 | 7,950
lung cancer 29 | 4,740
psoriasis 28 | 6,694
Breast cancer 20 | 3,578
Cancer 20 | 2,499
glioblastoma 19 | 5,792
group 3 medulloblastoma 18 | 4,104
lung adenocarcinoma 18 | 2,716
medulloblastoma, large-cell 18 | 6,241
Multiple myeloma 17 | 1,332
atypical teratoid / rhabdoid tumor 15 | 5,112
ependymoma 14 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
primitive neuroectodermal tumor 14 | 3,035
invasive ductal carcinoma 13 | 2,951
Kidney cancer 12 | 2,613
non-small cell lung cancer 12 | 2,890
ductal carcinoma in situ 11 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
breast carcinoma 10 | 1,638
group 4 medulloblastoma 10 | 1,855
malignant mesothelioma 10 | 3,232
Schizophrenia 9 | 1,160
astrocytoma 9 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
pancreatic cancer 9 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Intellectual disability 8 | 1,016
Rheumatoid arthritis 8 | 1,191
Waldenstrons macroglobulinemia 8 | 765
colon cancer 8 | 1,478
dermatomyositis 8 | 966
oligodendroglioma 8 | 2,850
pediatric high grade glioma 8 | 1,064
Cleft Palate 7 | 271
adult high grade glioma 7 | 3,801
diabetes mellitus 7 | 1,728
subependymal giant cell astrocytoma 7 | 2,287
Broad flat nasal bridge 6 | 236
Endometriosis 6 | 540
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Nasal bridge wide 6 | 236
acute myeloid leukemia 6 | 783
astrocytic glioma 6 | 2,597
spina bifida 6 | 1,074
Astrocytoma, Pilocytic 5 | 3,081
Breast Neoplasms 5 | 445
Dull intelligence 5 | 645
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Pick disease 5 | 1,894
Poor school performance 5 | 645
Small head 5 | 374
Strabismus 5 | 270
acute quadriplegic myopathy 5 | 1,158
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
nasopharyngeal carcinoma 5 | 1,058
Adenocarcinoma of lung 4 | 142
Autistic Disorder 4 | 364
Bipolar Disorder 4 | 666
Cataract 4 | 297
Decreased projection of maxilla 4 | 66
Deficiency of upper jaw bones 4 | 66
Downward slant of palpebral fissure 4 | 158
Epilepsy 4 | 792
Hypoplasia of the maxilla 4 | 66
Hypotrophic maxilla 4 | 66
Low Vision 4 | 174
Mammary Neoplasms 4 | 425
Maxillary retrognathia 4 | 66
Mood Disorders 4 | 184
Muscle hypotonia 4 | 571
Retrusion of upper jaw bones 4 | 66
Seizures 4 | 596
Short stature 4 | 531
Treacher Collins syndrome 4 | 27
Uranostaphyloschisis 4 | 167
Visual Impairment 4 | 174
non-small cell lung carcinoma 4 | 317
primary pancreatic ductal adenocarcinoma 4 | 1,109
sonic hedgehog group medulloblastoma 4 | 467
Attention deficit hyperactivity disorder 3 | 278
Cockayne syndrome 3 | 60
Depressive disorder 3 | 409
Down syndrome 3 | 499
Long philtrum 3 | 137
Mental Depression 3 | 333
active Crohn's disease 3 | 922
atypical teratoid/rhabdoid tumor 3 | 357
gastric carcinoma 3 | 807
juvenile dermatomyositis 3 | 1,187
pancreatic carcinoma 3 | 562
pituitary cancer 3 | 1,972
tuberculosis 3 | 2,010

Tissue

Endocrine System 71 | 18,159
Blood and immune system 70 | 16,909
Digestive Tract 70 | 17,369
Female tissues 70 | 17,400
Skin and soft tissues 70 | 17,230
Cardiovascular System 69 | 15,192
Liver and Pancreas 69 | 16,750
Male tissues 69 | 17,142
Nervous System 69 | 16,725
Respiratory system 69 | 16,393
Urinary Tract 69 | 16,678

Target Family

Non-IDG 38 | 12,091
Enzyme 18 | 4,145
Epigenetic 10 | 242
Transcription Factor 6 | 1,400
Kinase 1 | 634

Reactome Pathway

Positive epigenetic regulation... 73 | 73
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Transcriptional repressor p66-beta GATAD2B Tbio Transcription Factor -1.00210 9.37 215
DNA-directed RNA polymerase I subunit RPA43 TWISTNB Tdark Enzyme -0.05799 1.13 69
Transcriptional repressor p66-alpha GATAD2A Tbio Non-IDG -0.85553 8.21 159
Histone-binding protein RBBP4 RBBP4 Tbio Non-IDG -1.71209 53.9 310
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955
DNA-directed RNA polymerases I and III subunit RPAC1 POLR1C Tbio Enzyme -1.58188 37.0 209
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775
Actin, cytoplasmic 1 ACTB Tbio Non-IDG -3.52930 2830.7 1251