Development Level

Tbio 49 | 10,625
Tdark 14 | 7,003
Tchem 5 | 1,890
Tclin 3 | 602

IMPC Term

preweaning lethality, complete... 4 | 633
decreased body weight 3 | 174
abnormal behavior 2 | 226
decreased lumbar vertebrae num... 2 | 62
embryonic lethality prior to o... 2 | 148
increased sacral vertebrae num... 2 | 62
abnormal bone mineralization 1 | 55
abnormal maxilla morphology 1 | 16
abnormal tooth morphology 1 | 24
decreased Ly6C low monocyte nu... 1 | 23
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased heart left ventricle... 1 | 2
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased rib number 1 | 59
embryonic lethality prior to t... 1 | 187
hypoactivity 1 | 89
increased circulating alkaline... 1 | 119
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased plasma cell number 1 | 5
thick ventricular wall 1 | 7
thin ventricular wall 1 | 5
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

ovarian cancer 42 | 8,484
osteosarcoma 30 | 7,933
psoriasis 28 | 6,685
lung cancer 26 | 4,466
Cancer 19 | 2,346
glioblastoma 19 | 5,572
lung adenocarcinoma 18 | 2,713
medulloblastoma, large-cell 18 | 6,234
Breast cancer 17 | 3,094
Multiple myeloma 17 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
primitive neuroectodermal tumor 14 | 3,031
invasive ductal carcinoma 13 | 2,950
atypical teratoid / rhabdoid tumor 11 | 4,369
ductal carcinoma in situ 11 | 1,745
ependymoma 11 | 2,514
group 3 medulloblastoma 11 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
non-small cell lung cancer 11 | 2,798
breast carcinoma 10 | 1,614
pediatric high grade glioma 10 | 2,712
astrocytoma 9 | 1,493
group 4 medulloblastoma 9 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
malignant mesothelioma 9 | 3,162
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
sonic hedgehog group medulloblastoma 9 | 1,482
Rheumatoid Arthritis 8 | 1,160
Waldenstrons macroglobulinemia 8 | 765
colon cancer 8 | 1,475
oligodendroglioma 8 | 2,849
pancreatic cancer 8 | 2,300
Carcinoma 7 | 2,147
atypical teratoid/rhabdoid tumor 7 | 1,095
dermatomyositis 7 | 933
diabetes mellitus 7 | 1,663
subependymal giant cell astrocytoma 7 | 2,287
Endometriosis 6 | 535
acute myeloid leukemia 6 | 780
astrocytic glioma 6 | 2,241
spina bifida 6 | 1,064
Intellectual disability 5 | 573
Pick disease 5 | 1,893
acute quadriplegic myopathy 5 | 1,157
adult high grade glioma 5 | 2,148
cutaneous lupus erythematosus 5 | 1,056
cystic fibrosis 5 | 1,665
medulloblastoma 5 | 1,524
nasopharyngeal carcinoma 5 | 1,056
non-small cell lung carcinoma 5 | 413
pilocytic astrocytoma 5 | 3,086
posterior fossa group A ependymoma 5 | 1,511
Mammary Neoplasms 4 | 410
primary pancreatic ductal adenocarcinoma 4 | 1,271
Bipolar Disorder 3 | 266
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Dementia 3 | 129
Down syndrome 3 | 548
Leishmaniasis 3 | 49
Lung Neoplasms 3 | 171
Lupus erythematosus 3 | 80
Melanoma 3 | 261
Schizophrenia 3 | 501
Treacher Collins syndrome 3 | 29
active Crohn's disease 3 | 918
gastric cancer 3 | 430
gastric carcinoma 3 | 832
juvenile dermatomyositis 3 | 1,189
lung carcinoma 3 | 2,844
pancreatic carcinoma 3 | 567
pituitary cancer 3 | 1,972
tuberculosis 3 | 1,557
Alzheimer's disease 2 | 644
Attention deficit hyperactivity disorder 2 | 156
Autistic Disorder 2 | 320
Cardiomegaly 2 | 66
Chronic Lymphocytic Leukemia 2 | 242
Craniofacial Abnormalities 2 | 147
Dystonia 2 | 77
Endometrial Neoplasms 2 | 50
Juvenile rheumatoid arthritis 2 | 104
Neoplasm Invasiveness 2 | 127
Neurodegenerative disease 2 | 383
Peripheral T-cell lymphoma 2 | 24
Primary cutaneous T-cell lymphoma 2 | 24
Squamous cell carcinoma 2 | 94
Squamous cell carcinoma of esophagus 2 | 82
Vaccinia 2 | 37
Vascular disease 2 | 281
Williams-Beuren syndrome 2 | 45
adrenocortical carcinoma 2 | 1,427
glioblastoma multiforme 2 | 347
hepatocellular carcinoma 2 | 532
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299
mucosa-associated lymphoid tissue lymphoma 2 | 480
primary Sjogren syndrome 2 | 789
tuberculosis and treatment for 3 months 2 | 327
ulcerative colitis 2 | 2,087

Tissue

Female tissues 71 | 18,647
Male tissues 71 | 17,969
Blood and immune system 70 | 17,995
Cardiovascular System 70 | 17,958
Digestive Tract 70 | 18,473
Endocrine System 70 | 18,512
Nervous System 70 | 18,561
Urinary Tract 70 | 18,444
Liver and Pancreas 69 | 18,136
Respiratory system 69 | 17,484
Skin and soft tissues 63 | 18,115

Target Family

Non-IDG 36 | 11,971
Enzyme 18 | 4,146
Epigenetic 10 | 242
Transcription Factor 6 | 1,400
Kinase 1 | 634

Reactome Pathway

Positive epigenetic regulation... 71 | 71
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcriptional repressor p66-alpha GATAD2A Tbio Non-IDG -0.79314 7.11 142
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
DNA-directed RNA polymerase I subunit RPA34 CD3EAP Tbio Enzyme -1.07100 12.5 182
DNA-directed RNA polymerases I, II, and III subunit RPABC5 POLR2L Tbio Enzyme -0.98287 10.2 60
DNA-directed RNA polymerases I and III subunit RPAC1 POLR1C Tbio Enzyme -1.58939 36.9 190
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.89136 7.36 47
DNA-directed RNA polymerase I subunit RPA43 TWISTNB Tdark Enzyme 0.41 0.64 59
Transcriptional repressor p66-beta GATAD2B Tbio Transcription Factor -0.86137 7.48 174
Methyl-CpG-binding domain protein 3 MBD3 Tbio Transcription Factor -0.80239 7.92 283