Development Level

Tchem 7 | 1,885
Tbio 6 | 11,178
Tdark 2 | 6,569

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased vertical activity 1 | 208
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46

Disease

Carcinoma 12 | 11,192
Breast cancer 11 | 3,469
Cancer 10 | 2,388
medulloblastoma, large-cell 10 | 6,086
psoriasis 10 | 6,514
group 3 medulloblastoma 9 | 4,002
ovarian cancer 9 | 8,297
malignant mesothelioma 8 | 3,135
non-small cell lung cancer 8 | 2,799
atypical teratoid / rhabdoid tumor 7 | 4,971
glioblastoma 7 | 5,635
lung adenocarcinoma 7 | 2,627
osteosarcoma 7 | 7,766
adult high grade glioma 6 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,204
lung cancer 6 | 4,607
primitive neuroectodermal tumor 6 | 2,957
adrenocortical carcinoma 5 | 1,385
breast carcinoma 5 | 1,589
ductal carcinoma in situ 5 | 1,686
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,902
invasive ductal carcinoma 5 | 2,867
Endometriosis 4 | 521
ependymoma 4 | 4,559
Atopic dermatitis 3 | 915
Breast Neoplasms 3 | 423
Kidney cancer 3 | 2,548
Mammary Neoplasms 3 | 403
Retinoblastoma 3 | 18
colon cancer 3 | 1,428
pancreatic cancer 3 | 2,322
Agenesis of corpus callosum 2 | 79
Ataxia telangiectasia 2 | 33
Broad flat nasal bridge 2 | 232
Central pontine myelinolysis 2 | 5
Hypoplastic mandible condyle 2 | 273
Leukemia 2 | 103
Low set ears 2 | 178
Lymphoid leukemia 2 | 156
Mandibular hypoplasia 2 | 273
Melanoma 2 | 689
Micrognathism 2 | 273
Nasal bridge wide 2 | 232
Pleural empyema 2 | 12
Schizophrenia 2 | 1,136
Small head 2 | 366
Waldenstrons macroglobulinemia 2 | 742
Western equine encephalitis 2 | 12
interstitial cystitis 2 | 2,237
nasopharyngeal carcinoma 2 | 1,024
tuberculosis 2 | 1,963
Achondroplasia 1 | 21
Acquired flat foot 1 | 70
Adenocarcinoma of lung (disorder) 1 | 59
Angle class 2 malocclusion 1 | 57
Angle class 3 malocclusion 1 | 57
Bifid uterus 1 | 3
Birthmark 1 | 35
Bowed and upward slanting eyebrows 1 | 39
Bushy eyebrows 1 | 48
Cafe-au-Lait Spots 1 | 37
Carcinoma, squamous cell of head and neck 1 | 30
Cervical vertebral abnormalities 1 | 6
Chorioretinal dystrophy 1 | 4
Complex regional pain syndrome 1 | 12
Congenital anomaly of the kidney 1 | 12
Conversion disorder 1 | 6
Dens evaginatus 1 | 3
Extra cusp on inside of front tooth 1 | 3
Flatfoot 1 | 71
Gait, Unsteady 1 | 29
Hemoglobin E disease 1 | 3
Hereditary nonpolyposis colorectal carcinoma 1 | 18
Hyperglycemia 1 | 134
Increased gastric cancer 1 | 21
Joint laxity 1 | 52
Keloid 1 | 37
Lacrimal Duct Obstruction 1 | 16
Laryngomalacia 1 | 13
Leiomyosarcoma of uterus 1 | 13
Liver Neoplasms, Experimental 1 | 58
Lymphoma, T-Cell 1 | 13
Malocclusion 1 | 57
Mild Mental Retardation 1 | 68
Obesity, Abdominal 1 | 23
Obstruction of nasolacrimal duct 1 | 9
Papillary cystadenoma of the epididymis 1 | 3
Phonophobia 1 | 11
Postnatal growth retardation 1 | 56
Sleep Apnea, Obstructive 1 | 10
Small Cell Lung Carcinoma 1 | 39
Small cell carcinoma of lung 1 | 43
Strawberry nevus of skin 1 | 10
Substance abuse 1 | 58
T-Cell Lymphoma 1 | 13
Talon cusp 1 | 3
Thick, flared eyebrows 1 | 39
Transitional cell carcinoma of bladder 1 | 17
locked-in syndrome 1 | 14
maturity-onset diabetes of the young 1 | 32

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Non-IDG 7 | 12,091
Kinase 3 | 634
Enzyme 2 | 4,145
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Polo-like kinase mediated even... 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.27237 19.2 364
Centromere protein F CENPF Tbio Non-IDG -2.02939 109.1 186
Protein lin-52 homolog LIN52 Tbio Non-IDG -0.97901 7.87 61
Myb-related protein B MYBL2 Tbio Transcription Factor -2.19738 169.0 289
Protein lin-54 homolog LIN54 Tdark Non-IDG -1.29119 19.5 45
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.15430 1384.8 332
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775
Serine/threonine-protein kinase PLK1 PLK1 Tchem Kinase -3.09610 1271.1 856
Histone-binding protein RBBP4 RBBP4 Tbio Non-IDG -1.71209 53.9 310
Protein lin-9 homolog LIN9 Tbio Non-IDG -1.92491 83.2 101