Development Level

Tchem 8 | 1,890
Tbio 5 | 10,625
Tdark 3 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 4 | 187
preweaning lethality, complete... 3 | 633
decreased circulating serum al... 1 | 79
urinary bladder obstruction 1 | 2

Disease

medulloblastoma, large-cell 11 | 6,234
psoriasis 11 | 6,685
Cancer 10 | 2,346
ovarian cancer 10 | 8,484
Breast cancer 9 | 3,094
non-small cell lung cancer 9 | 2,798
glioblastoma 8 | 5,572
lung adenocarcinoma 8 | 2,713
malignant mesothelioma 8 | 3,162
group 3 medulloblastoma 7 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
osteosarcoma 7 | 7,933
pediatric high grade glioma 7 | 2,712
primitive neuroectodermal tumor 7 | 3,031
adrenocortical carcinoma 6 | 1,427
breast carcinoma 6 | 1,614
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
invasive ductal carcinoma 6 | 2,950
lung cancer 6 | 4,466
Endometriosis 5 | 535
atypical teratoid / rhabdoid tumor 5 | 4,369
posterior fossa group A ependymoma 5 | 1,511
Atopic dermatitis 4 | 944
IGA Glomerulonephritis 4 | 454
colon cancer 4 | 1,475
pancreatic cancer 4 | 2,300
sonic hedgehog group medulloblastoma 4 | 1,482
Mammary Neoplasms 3 | 410
atypical teratoid/rhabdoid tumor 3 | 1,095
nasopharyngeal carcinoma 3 | 1,056
Carcinoma 2 | 2,147
Central pontine myelinolysis 2 | 5
Melanoma 2 | 261
Retinoblastoma 2 | 14
Waldenstrons macroglobulinemia 2 | 765
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299
tuberculosis 2 | 1,557
Achondroplasia 1 | 20
Adenoid Cystic Carcinoma 1 | 99
Adenoma 1 | 165
Alcohol dependence 1 | 107
Amnestic disorder 1 | 37
Asphyxiating thoracic dystrophy 1 | 32
Ataxia telangiectasia 1 | 31
Attention deficit hyperactivity disorder 1 | 156
Bipolar Disorder 1 | 266
Bladder Neoplasm 1 | 109
Brain disease 1 | 83
Carcinoma, Transitional Cell 1 | 31
Cerebrovascular disease 1 | 231
Colon Carcinoma 1 | 25
Colorectal Neoplasms 1 | 217
Complex regional pain syndrome 1 | 12
Conversion disorder 1 | 7
Crohn's disease 1 | 304
Dementia 1 | 129
Dental fluorosis 1 | 16
Dyslexia 1 | 36
Endometrial Neoplasms 1 | 50
Glioma 1 | 65
Hyperglycemia 1 | 120
Kidney cancer 1 | 118
Leukemia 1 | 88
Liver Neoplasms, Experimental 1 | 48
Liver carcinoma 1 | 217
Lung Neoplasms 1 | 171
Major Depressive Disorder 1 | 106
Neurodegenerative disease 1 | 383
Neutropenia 1 | 78
Pick disease 1 | 1,893
Polycystic Ovary Syndrome 1 | 332
Precancerous Conditions 1 | 69
Primary ciliary dyskinesia 1 | 73
Prostate cancer 1 | 172
Rubinstein-Taybi syndrome 1 | 11
Schizophrenia 1 | 501
Small cell carcinoma of lung 1 | 45
Squamous cell carcinoma of esophagus 1 | 82
Stevens-Johnson syndrome 1 | 78
T-Cell Lymphoma 1 | 11
X-linked cerebral adrenoleukodystrophy 1 | 115
acute myeloid leukemia 1 | 780
adult high grade glioma 1 | 2,148
astrocytic glioma 1 | 2,241
astrocytoma 1 | 1,493
cartilage-hair hypoplasia 1 | 7
chronic rhinosinusitis 1 | 512
cutaneous lupus erythematosus 1 | 1,056
diabetes mellitus 1 | 1,663
facioscapulohumeral dystrophy 1 | 286
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,956
locked-in syndrome 1 | 10
maturity-onset diabetes of the young 1 | 28
non-small cell lung carcinoma 1 | 413
oligodendroglioma 1 | 2,849
pilocytic astrocytoma 1 | 3,086
pituitary cancer 1 | 1,972
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Blood and immune system 16 | 17,995
Cardiovascular System 16 | 17,958
Digestive Tract 16 | 18,473
Endocrine System 16 | 18,512
Female tissues 16 | 18,647
Liver and Pancreas 16 | 18,136
Male tissues 16 | 17,969
Nervous System 16 | 18,561
Respiratory system 16 | 17,484
Skin and soft tissues 16 | 18,115
Urinary Tract 16 | 18,444

Target Family

Non-IDG 8 | 11,971
Kinase 3 | 634
Enzyme 2 | 4,146
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Polo-like kinase mediated even... 16 | 16
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Centromere protein F CENPF Tbio Non-IDG -1.98596 103.0 180
Protein lin-9 homolog LIN9 Tbio Non-IDG -1.88736 79.3 89
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.75838 5701.8 723
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.21083 17.2 317
Serine/threonine-protein kinase PLK1 PLK1 Tchem Kinase -3.03730 1176.3 707
Histone-binding protein RBBP4 RBBP4 Tbio Non-IDG -1.66776 51.8 276
Myb-related protein B MYBL2 Tbio Transcription Factor -2.15851 159.3 268
Protein lin-54 homolog LIN54 Tdark Non-IDG -1.23050 17.5 44