Development Level

Tbio 40 | 10,625
Tchem 31 | 1,890
Tclin 13 | 602
Tdark 7 | 7,003

Collection

Ion Channel: IDG Consortium (Targets) 2 | 102

IMPC Phenotype

abnormal bone mineralization 4 | 55
abnormal bone structure 4 | 131
increased heart weight 4 | 37
preweaning lethality, incomple... 4 | 260
preweaning lethality, complete... 3 | 633
decreased circulating amylase ... 2 | 24
decreased circulating glycerol... 2 | 19
decreased lean body mass 2 | 195
embryonic lethality prior to t... 2 | 187
abnormal behavior 1 | 226
abnormal clavicle morphology 1 | 5
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal forebrain development 1 | 18
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal response to new envir... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal sensory capabilities-... 1 | 3
abnormal vibrissa morphology 1 | 17
absent vibrissae 1 | 14
corneal vascularization 1 | 5
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
enlarged epididymis 1 | 27
hyperactivity 1 | 108
increased caudal vertebrae num... 1 | 8
increased circulating choleste... 1 | 53
increased circulating sodium l... 1 | 71
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
male infertility 1 | 62
short tibia 1 | 82
small epididymis 1 | 3
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

medulloblastoma, large-cell 51 | 6,234
osteosarcoma 50 | 7,933
glioblastoma 47 | 5,572
ovarian cancer 45 | 8,491
atypical teratoid / rhabdoid tumor 36 | 4,369
psoriasis 34 | 6,685
lung cancer 30 | 4,473
Carcinoma 27 | 2,147
pilocytic astrocytoma 27 | 3,086
oligodendroglioma 26 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
astrocytic glioma 24 | 2,241
pituitary cancer 24 | 1,972
Pick disease 23 | 1,893
lung adenocarcinoma 23 | 2,714
lung carcinoma 23 | 2,844
pediatric high grade glioma 23 | 2,712
primitive neuroectodermal tumor 23 | 3,031
subependymal giant cell astrocytoma 23 | 2,287
ulcerative colitis 23 | 2,087
ependymoma 22 | 2,514
interstitial cystitis 22 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
invasive ductal carcinoma 22 | 2,950
Breast cancer 21 | 3,098
malignant mesothelioma 19 | 3,163
non-small cell lung cancer 19 | 2,798
Cancer 17 | 2,346
colon cancer 17 | 1,475
group 4 medulloblastoma 17 | 1,875
pancreatic cancer 17 | 2,300
adult high grade glioma 16 | 2,148
breast carcinoma 15 | 1,614
cystic fibrosis 15 | 1,670
Obesity 14 | 616
posterior fossa group B ependymoma 14 | 1,530
ductal carcinoma in situ 13 | 1,745
group 3 medulloblastoma 13 | 2,254
Chronic heart failure 12 | 46
Hypertension 12 | 293
tuberculosis 12 | 1,563
Hypertensive disease 11 | 193
Rheumatoid Arthritis 10 | 1,170
medulloblastoma 10 | 1,524
Atrial Fibrillation 9 | 110
Kidney disease 9 | 397
Pulmonary hypertension 9 | 52
astrocytoma 9 | 1,493
primary Sjogren syndrome 9 | 788
sonic hedgehog group medulloblastoma 9 | 1,482
Impotence 8 | 45
Myocardial Perfusion Imaging Adjunct 8 | 25
Platelet Aggregation Inhibition 8 | 22
Prevention of Cerebral Thrombosis 8 | 29
cutaneous lupus erythematosus 8 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Adenoma 7 | 165
Coronary artery disease 7 | 240
active Crohn's disease 7 | 918
atypical teratoid/rhabdoid tumor 7 | 1,095
diabetes mellitus 7 | 1,663
posterior fossa group A ependymoma 7 | 1,511
progressive supranuclear palsy 7 | 674
Autistic Disorder 6 | 320
Brain Ischemia 6 | 87
Kidney cancer 6 | 121
Multiple myeloma 6 | 1,327
Neurodegenerative disease 6 | 383
Status Epilepticus 6 | 85
Waldenstrons macroglobulinemia 6 | 764
adrenocortical carcinoma 6 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
gastric carcinoma 6 | 832
pancreatic carcinoma 6 | 567
Bipolar Disorder 5 | 266
Brachydactyly 5 | 52
Carney complex 5 | 23
Cushing's syndrome 5 | 47
Decompensated cardiac failure 5 | 9
Diabetes Mellitus, Non-Insulin-Dependent 5 | 161
Duchenne muscular dystrophy 5 | 602
Epilepsy 5 | 346
Essential Hypertension 5 | 82
Heart disease 5 | 279
Hypothyroidism 5 | 89
Intellectual disability 5 | 573
Mammary Neoplasms 5 | 410
Multiple Endocrine Neoplasia Type 1 5 | 30
Multiple Sclerosis 5 | 498
Polycystic Ovary Syndrome 5 | 334
Primary pigmented nodular adrenocortical disease 5 | 13
Schnyder Corneal Dystrophy 5 | 24
Seizures 5 | 95
Substance Withdrawal Syndrome 5 | 55
acute myeloid leukemia 5 | 785
chronic lymphocytic leukemia 5 | 244
dermatomyositis 5 | 966
juvenile dermatomyositis 5 | 1,189
primary pancreatic ductal adenocarcinoma 5 | 1,271

Tissue

Female tissues 89 | 18,646
Liver and Pancreas 89 | 18,135
Male tissues 89 | 17,968
Nervous System 89 | 18,560
Blood and immune system 88 | 17,994
Cardiovascular System 88 | 17,957
Digestive Tract 88 | 18,472
Endocrine System 88 | 18,511
Urinary Tract 88 | 18,443
Respiratory system 85 | 17,483
Skin and soft tissues 85 | 18,114

Target Family

Enzyme 29 | 4,146
Non-IDG 28 | 11,969
Ion Channel 19 | 341
Transporter 10 | 473
Kinase 4 | 634
GPCR 1 | 408

Reactome Pathway

Platelet homeostasis 91 | 91
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.85874 681.4 264
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.67695 418.8 220
Calcium-activated potassium channel subunit alpha-1 KCNMA1 Tclin Ion Channel -3.08349 1170.6 213