Development Level

Tbio 48 | 11,651
Tchem 25 | 1,388
Tclin 11 | 612
Tdark 4 | 6,593

Collection

Ion Channel: IDG Consortium (T... 2 | 99
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, incomple... 7 | 499
increased startle reflex 6 | 112
abnormal bone structure 5 | 187
increased heart weight 4 | 62
preweaning lethality, complete... 4 | 979
abnormal embryo size 3 | 220
abnormal gait 2 | 69
decreased circulating amylase ... 2 | 28
decreased circulating glycerol... 2 | 16
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
decreased mean platelet volume 2 | 25
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
enlarged spleen 2 | 41
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal clavicle morphology 1 | 6
abnormal duodenum morphology 1 | 4
abnormal epididymis morphology 1 | 42
abnormal forelimb morphology 1 | 2
abnormal locomotor activation 1 | 16
abnormal locomotor behavior 1 | 24
abnormal response to new envir... 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal vibrissa morphology 1 | 25
absent vibrissae 1 | 12
cataract 1 | 92
corneal vascularization 1 | 6
decreased body weight 1 | 161
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
hyperactivity 1 | 148
hypoactivity 1 | 132
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
limb grasping 1 | 41
male infertility 1 | 123
mammalian phenotype 1 | 17
short tibia 1 | 97
small epididymis 1 | 3
small kidney 1 | 16
small superior vagus ganglion 1 | 74

Disease

Carcinoma 60 | 11,493
medulloblastoma, large-cell 49 | 6,241
osteosarcoma 48 | 7,950
glioblastoma 46 | 5,792
ovarian cancer 46 | 8,520
atypical teratoid / rhabdoid tumor 38 | 5,112
ependymoma 38 | 4,679
lung cancer 33 | 4,740
psoriasis 33 | 6,694
adult high grade glioma 31 | 3,801
group 3 medulloblastoma 28 | 4,104
Kidney cancer 26 | 2,613
astrocytic glioma 26 | 2,597
Astrocytoma, Pilocytic 25 | 3,081
Breast cancer 25 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
oligodendroglioma 25 | 2,850
pituitary cancer 24 | 1,972
lung adenocarcinoma 23 | 2,716
lung carcinoma 23 | 2,843
subependymal giant cell astrocytoma 23 | 2,287
primitive neuroectodermal tumor 22 | 3,035
Pick disease 21 | 1,894
invasive ductal carcinoma 21 | 2,951
interstitial cystitis 20 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
non-small cell lung cancer 20 | 2,890
malignant mesothelioma 18 | 3,232
ulcerative colitis 18 | 1,819
Cancer 17 | 2,499
Hypertension 16 | 396
colon cancer 15 | 1,478
pancreatic cancer 15 | 2,398
breast carcinoma 14 | 1,638
cystic fibrosis 14 | 1,696
group 4 medulloblastoma 14 | 1,855
Hypertensive disease 13 | 292
Bipolar Disorder 12 | 666
ductal carcinoma in situ 12 | 1,745
tuberculosis 12 | 2,010
Depressive disorder 11 | 409
Obesity 11 | 678
Chronic heart failure 10 | 46
Atrial Fibrillation 9 | 124
Epilepsy 9 | 792
Rheumatoid arthritis 9 | 1,191
Schizophrenia 9 | 1,160
Seizures 9 | 596
diabetes mellitus 9 | 1,728
Impotence 8 | 46
Kidney disease 8 | 430
Myocardial Perfusion Imaging Adjunct 8 | 25
Platelet Aggregation Inhibition 8 | 22
Prevention of Cerebral Thrombosis 8 | 29
cutaneous lupus erythematosus 8 | 1,057
primary Sjogren syndrome 8 | 735
Adenoma 7 | 167
Coronary artery disease 7 | 268
Mental Depression 7 | 333
Pulmonary hypertension 7 | 86
active Crohn's disease 7 | 922
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Asthma 6 | 385
Autistic Disorder 6 | 364
Autosomal recessive predisposition 6 | 1,442
Brachydactyly 6 | 156
Brain Ischemia 6 | 110
Intellectual disability 6 | 1,016
Liver Cirrhosis, Experimental 6 | 769
Liver cancer 6 | 604
Major Depressive Disorder 6 | 301
Multiple myeloma 6 | 1,332
Neurodegenerative disease 6 | 414
Status Epilepticus 6 | 98
Waldenstrons macroglobulinemia 6 | 765
adrenocortical carcinoma 6 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
pediatric high grade glioma 6 | 1,064
progressive supranuclear palsy 6 | 676
Breast Neoplasms 5 | 445
Carney complex 5 | 25
Chronic Lymphocytic Leukemia 5 | 262
Cushing's syndrome 5 | 48
Diabetes Mellitus, Non-Insulin-Dependent 5 | 145
Diabetes Mellitus, Type 2 5 | 142
Duchenne muscular dystrophy 5 | 601
Mammary Neoplasms 5 | 425
Multiple Endocrine Neoplasia Type 1 5 | 29
Multiple Sclerosis 5 | 540
Myocardial Infarction 5 | 151
Polycystic ovary syndrome 5 | 360
Primary pigmented nodular adrenocortical disease 5 | 13
Schnyder Corneal Dystrophy 5 | 23
Short stature 5 | 531
Substance Withdrawal Syndrome 5 | 55
astrocytoma 5 | 1,146
dermatomyositis 5 | 966
juvenile dermatomyositis 5 | 1,187
substance-related disorder 5 | 162

Tissue

Digestive Tract 83 | 17,369
Endocrine System 83 | 18,159
Female tissues 81 | 17,400
Male tissues 81 | 17,142
Nervous System 81 | 16,725
Skin and soft tissues 81 | 17,230
Urinary Tract 81 | 16,678
Blood and immune system 79 | 16,909
Liver and Pancreas 79 | 16,750
Respiratory system 76 | 16,393
Cardiovascular System 75 | 15,192

Target Family

Enzyme 27 | 4,145
Non-IDG 27 | 12,091
Ion Channel 19 | 344
Transporter 10 | 473
Kinase 4 | 634
GPCR 1 | 408

Reactome Pathway

Platelet homeostasis 88 | 88
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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