Development Level

Tbio 40 | 10,625
Tchem 31 | 1,890
Tclin 13 | 602
Tdark 7 | 7,003

Collection

Eligible Ion Channel Proteins 3 | 117

IMPC Term

abnormal bone mineralization 4 | 55
abnormal bone structure 4 | 131
increased heart weight 4 | 37
preweaning lethality, incomple... 4 | 260
preweaning lethality, complete... 3 | 633
decreased circulating amylase ... 2 | 24
decreased circulating glycerol... 2 | 19
decreased lean body mass 2 | 195
embryonic lethality prior to t... 2 | 187
abnormal behavior 1 | 226
abnormal clavicle morphology 1 | 5
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal forebrain development 1 | 18
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal response to new envir... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal sensory capabilities/... 1 | 3
abnormal vibrissa morphology 1 | 17
absent vibrissae 1 | 14
corneal vascularization 1 | 5
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
enlarged epididymis 1 | 27
hyperactivity 1 | 108
increased caudal vertebrae num... 1 | 8
increased circulating choleste... 1 | 53
increased circulating sodium l... 1 | 71
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
male infertility 1 | 62
short tibia 1 | 82
small epididymis 1 | 3
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

medulloblastoma, large-cell 51 | 6,234
osteosarcoma 50 | 7,933
glioblastoma 47 | 5,572
ovarian cancer 45 | 8,484
atypical teratoid / rhabdoid tumor 36 | 4,369
psoriasis 34 | 6,685
lung cancer 30 | 4,466
Carcinoma 27 | 2,147
pilocytic astrocytoma 27 | 3,086
oligodendroglioma 26 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
astrocytic glioma 24 | 2,241
pituitary cancer 24 | 1,972
Pick disease 23 | 1,893
lung adenocarcinoma 23 | 2,713
lung carcinoma 23 | 2,844
pediatric high grade glioma 23 | 2,712
primitive neuroectodermal tumor 23 | 3,031
subependymal giant cell astrocytoma 23 | 2,287
ulcerative colitis 23 | 2,087
ependymoma 22 | 2,514
interstitial cystitis 22 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
invasive ductal carcinoma 22 | 2,950
Breast cancer 21 | 3,094
malignant mesothelioma 19 | 3,162
non-small cell lung cancer 19 | 2,798
Cancer 17 | 2,346
colon cancer 17 | 1,475
group 4 medulloblastoma 17 | 1,875
pancreatic cancer 17 | 2,300
adult high grade glioma 16 | 2,148
breast carcinoma 15 | 1,614
Obesity 14 | 616
cystic fibrosis 14 | 1,665
posterior fossa group B ependymoma 14 | 1,530
ductal carcinoma in situ 13 | 1,745
group 3 medulloblastoma 13 | 2,254
Chronic heart failure 12 | 46
tuberculosis 12 | 1,557
Hypertension 11 | 287
Hypertensive disease 11 | 193
Rheumatoid Arthritis 10 | 1,160
medulloblastoma 10 | 1,524
Atrial Fibrillation 9 | 110
Kidney disease 9 | 396
Pulmonary hypertension 9 | 52
astrocytoma 9 | 1,493
primary Sjogren syndrome 9 | 789
sonic hedgehog group medulloblastoma 9 | 1,482
Impotence 8 | 45
Myocardial Perfusion Imaging Adjunct 8 | 25
Platelet Aggregation Inhibition 8 | 22
Prevention of Cerebral Thrombosis 8 | 29
cutaneous lupus erythematosus 8 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Adenoma 7 | 165
Coronary artery disease 7 | 240
active Crohn's disease 7 | 918
atypical teratoid/rhabdoid tumor 7 | 1,095
diabetes mellitus 7 | 1,663
posterior fossa group A ependymoma 7 | 1,511
progressive supranuclear palsy 7 | 674
Autistic Disorder 6 | 320
Brain Ischemia 6 | 87
Kidney cancer 6 | 118
Multiple myeloma 6 | 1,327
Neurodegenerative disease 6 | 383
Status Epilepticus 6 | 85
Waldenstrons macroglobulinemia 6 | 765
adrenocortical carcinoma 6 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
gastric carcinoma 6 | 832
pancreatic carcinoma 6 | 567
Bipolar Disorder 5 | 266
Brachydactyly 5 | 52
Carney complex 5 | 23
Chronic Lymphocytic Leukemia 5 | 242
Cushing's syndrome 5 | 47
Decompensated cardiac failure 5 | 9
Diabetes Mellitus, Non-Insulin-Dependent 5 | 157
Duchenne muscular dystrophy 5 | 602
Epilepsy 5 | 346
Essential Hypertension 5 | 82
Heart disease 5 | 279
Hypothyroidism 5 | 89
Intellectual disability 5 | 573
Mammary Neoplasms 5 | 410
Multiple Endocrine Neoplasia Type 1 5 | 30
Multiple Sclerosis 5 | 498
Primary pigmented nodular adrenocortical disease 5 | 12
Schnyder corneal dystrophy 5 | 23
Seizures 5 | 95
acute myeloid leukemia 5 | 780
dermatomyositis 5 | 933
juvenile dermatomyositis 5 | 1,189
primary pancreatic ductal adenocarcinoma 5 | 1,271
Myocardial Ischemia 4 | 169
aldosterone-producing adenoma 4 | 664

Tissue

Female tissues 89 | 18,647
Liver and Pancreas 89 | 18,136
Male tissues 89 | 17,969
Nervous System 89 | 18,561
Blood and immune system 88 | 17,995
Cardiovascular System 88 | 17,958
Digestive Tract 88 | 18,473
Endocrine System 88 | 18,512
Urinary Tract 88 | 18,444
Respiratory system 85 | 17,484
Skin and soft tissues 85 | 18,115

Target Family

Enzyme 29 | 4,146
Non-IDG 28 | 11,971
Ion Channel 19 | 341
Transporter 10 | 473
Kinase 4 | 634
GPCR 1 | 406

Reactome Pathway

Platelet homeostasis 91 | 91
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.56223 31.9 51
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.32560 2206.3 649
P2X purinoceptor 6 P2RX6 Tchem Ion Channel -1.46223 26.9 118
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.06784 1308.8 971
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 GNB2 Tbio Non-IDG -0.43889 2.98 102
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 Tbio Non-IDG -1.15715 18.1 144
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A Tchem Enzyme -1.87754 73.1 142
Plasma membrane calcium-transporting ATPase 2 ATP2B2 Tbio Transporter -2.03165 116.3 74
Protein orai-2 ORAI2 Tbio Non-IDG -1.13604 11.2 95